Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Laura Hulea Clear advanced filters

  • The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.

    • Slim Mzoughi
    • Jia Yi Fong
    • Ernesto Guccione
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Dysregulation of mRNA translation is a frequent occurrence in cancer cells, and several components of the translation machinery have emerged as promising targets for anticancer therapeutics. This Review discusses the mechanisms of aberrant mRNA translation in cancer cells and provides an overview of drugs in development that target the translation machinery.

    • Mamatha Bhat
    • Nathaniel Robichaud
    • Ivan Topisirovic
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 261-278

  • ZO-1, a cell junction protein, is essential for angiogenesis. Here the authors identify in endothelial cells unexpected associations of ZO-1 with stress granule proteins, such as YB-1, that are crucial for cytoprotection, implicating the ZO-1-YB-1 interaction in angiogenesis.

    • Yassine El Bakkouri
    • Rony Chidiac
    • Jean-Philippe Gratton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient replenishment.

    • Maxime Uriarte
    • Nadine Sen Nkwe
    • El Bachir Affar
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22

  • Design of a bivalent inhibitor containing an ATP-competitive moiety and rapamycin-modified FRB binding ligand that selectively inhibits mTORC1 results in potent and durable inhibition of 4EBP1 phosphorylation and cell proliferation in vitro and in vivo.

    • Bianca J. Lee
    • Jacob A. Boyer
    • Neal Rosen
    Research
    Nature Chemical Biology
    Volume: 17, P: 1065-1074

  • Oncogenic mutations of isocitrate dehydrogenases 1 and 2 result in the production of the oncometabolite R-2-hydroxyglutarate. Here the authors show that the oncometabolite promotes mTOR activation in a PTEN/PI3K-independent manner by regulating DEPTOR stability via inhibition of KDM4A activity.

    • Mélissa Carbonneau
    • Laurence M. Gagné
    • Frédérick A. Mallette
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12