Nature Search

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype

Enrichment of oral microbiota in the bronchoalveolar lavage of apparently healthy people is associated with a pro-inflammatory phenotype, suggesting that aspiration-derived microbiota play a role in regulating basal inflammatory status.

Leopoldo N. Segal
Jose C. Clemente
Michael D. Weiden
Research04 Apr 2016
Nature Microbiology

Volume: 1, P: 1-11
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

Paris et al. show that after injury or influenza infection alveolar type II cells signal via a STAT3–BDNF axis that activates the TrkB receptor on mesenchymal niche cells and enhances alveolar repair.

Andrew J. Paris
Katharina E. Hayer
G. Scott Worthen
Research28 Sept 2020
Nature Cell Biology

Volume: 22, P: 1197-1210
Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V β expression

Jeffrey Laurence
Andrew S. Hodtsev
David N. Posnett
Research16 Jul 1992
Nature

Volume: 358, P: 255-259
¹⁸F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies

In this study, the authors describe an imaging technology, ¹⁸F-FDS PET, for noninvasive detection, localization and monitoring of invasive mold infections, including Aspergillus, non-Aspergillus and azole-resistant molds, throughout the body.

Carlos E. Ruiz-Gonzalez
Oscar J. Nino-Meza
Sanjay K. Jain
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients

Guillaume Voiriot
Karim Dorgham
Antonin Lamazière
ResearchOpen Access09 Jun 2022
Scientific Reports

Volume: 12, P: 1-14
Dystrophin expression in the human retina is required for normal function as defined by electroretinography

De-Ann M. Pillers
Dennis E. Bulman
Peter N. Ray
Research01 May 1993
Nature Genetics

Volume: 4, P: 82-86
Metabolic plasticity of HIV-specific CD8⁺ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

Spontaneous control of HIV is linked to the ability of CD8⁺ T cells to eliminate infected CD4⁺ T cells. Here, the authors uncover metabolic differences between HIV-specific, central memory CD8⁺ T cells from spontaneous HIV controllers and antiretrovirally treated non-controllers, and show that in vitro metabolic reprogramming enhances the antiviral response in non-controllers cells.

Mathieu Angin
Stevenn Volant
Asier Sáez-Cirión
Research12 Jul 2019
Nature Metabolism

Volume: 1, P: 704-716
Presentation of the Howland Award, May, 1983

Laurence Finberg
Research01 Nov 1983
Pediatric Research

Volume: 17, P: 843-847
RAGE inhibition reduces acute lung injury in mice

Raiko Blondonnet
Jules Audard
Matthieu Jabaudon
ResearchOpen Access03 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

A rare sub-population of people living with HIV-1 experience long-lasting viral remission after interrupting antiretroviral therapy and are considered post-treatment controllers. Here the authors characterise the humoral immune response to HIV-1 in a cohort of post-treatment controllers.

Luis M. Molinos-Albert
Valérie Lorin
Laetitia Laine
ResearchOpen Access11 Apr 2022
Nature Communications

Volume: 13, P: 1-17
Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Africa-specific genetic variation on chromosome 1 near CHD1L is associated with HIV replication in vivo.

Paul J. McLaren
Immacolata Porreca
Jacques Fellay
Research02 Aug 2023
Nature

Volume: 620, P: 1025-1030
A multiplexed, next generation sequencing platform for high-throughput detection of SARS-CoV-2

Wide-spread outbreaks of pathogens require high intensity testing to manage. Here, the authors present C19-SPAR-Seq, a scalable and automated platform to analyse tens of thousands of SARS-CoV-2 patient samples in a single run.

Marie-Ming Aynaud
J. Javier Hernandez
Jeffrey L. Wrana
ResearchOpen Access03 Mar 2021
Nature Communications

Volume: 12, P: 1-10
Autocrine vitamin D signaling switches off pro-inflammatory programs of T_H1 cells

During homeostasis T_H1 cells activate a cell-intrinsic inflammatory shutdown program and shift to IL-10 production. Chauss et al. find that this T_H1 homeostatic program is dependent on vitamin D signaling and is disrupted in severe COVID-19.

Daniel Chauss
Tilo Freiwald
Behdad Afzali
Research11 Nov 2021
Nature Immunology

Volume: 23, P: 62-74
Inferring structural variant cancer cell fraction

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Marek Cmero
Ke Yuan
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Detection and prevalence of SARS-CoV-2 co-infections during the Omicron variant circulation in France

Monitoring of co-infections of SARS-CoV-2 variants is important to evaluate their clinical impact and the risk of emergence of recombinants. Here, the authors develop and validate a methodological pipeline to detect co-infections and apply it to samples from France in early 2022, when Delta and Omicron were co-circulating.

Antonin Bal
Bruno Simon
Laurence Josset
ResearchOpen Access23 Oct 2022
Nature Communications

Volume: 13, P: 1-9
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring the development of hypoxic granulomas in human disease progression.

Daria Bottai
Wafa Frigui
Roland Brosch
ResearchOpen Access04 Feb 2020
Nature Communications

Volume: 11, P: 1-14
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

Retinoblastoma is the most frequent intraocular paediatric malignancy whose molecular basis remains poorly understood. Here, the authors perform multi-omic analysis and identify two subtypes; one in a cone differentiated state and one more aggressive showing cone dedifferentiation and expressing neuronal markers.

Jing Liu
Daniela Ottaviani
François Radvanyi
ResearchOpen Access22 Sept 2021
Nature Communications

Volume: 12, P: 1-20
The DNA sequence and analysis of human chromosome 14

Roland Heilig
Ralph Eckenberg
Jean Weissenbach
Research01 Jan 2003
Nature

Volume: 421, P: 601-607
Pri peptides are mediators of ecdysone for the temporal control of development

Payre and colleagues identify a gene, GstE14, needed for production of the insect steroid hormone ecdysone and find that this hormone acts through Pri peptides to control the timing of differentiation events.

Hélène Chanut-Delalande
Yoshiko Hashimoto
François Payre
Research26 Oct 2014
Nature Cell Biology

Volume: 16, P: 1035-1044
LEAD: TOXICITY AND TISSUE LEVELS IN THE EMBRYO

Joseph Kochen
Yigal Greener
Laurence Finberg
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 358
HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension

Sharilyn Almodovar
Brandy E. Wade
Roy L. Sutliff
ResearchOpen Access16 Jul 2020
Scientific Reports

Volume: 10, P: 1-15
Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination

An observational study of more than 13,000 healthcare workers shows that a prime–boost vaccine regimen of AstraZeneca ChAdOx1-S-nCoV-19 with Pfizer BNT162b2 provides enhanced protection against SARS-CoV-2 infection compared with two doses of BNT162b2.

Bruno Pozzetto
Vincent Legros
Sophie Trouillet-Assant
Research21 Oct 2021
Nature

Volume: 600, P: 701-706
Gene set enrichment analysis of the bronchial epithelium implicates contribution of cell cycle and tissue repair processes in equine asthma

Laurence Tessier
Olivier Côté
Dorothee Bienzle
ResearchOpen Access06 Nov 2018
Scientific Reports

Volume: 8, P: 1-15
An Alveolata secretory machinery adapted to parasite host cell invasion

The architecture and molecular composition of the rhoptry secretion system in Apicomplexa evolved from an Alveolata-specific fusion machinery ancestry.

Eleonora Aquilini
Marta Mendonça Cova
Maryse Lebrun
Research25 Jan 2021
Nature Microbiology

Volume: 6, P: 425-434
Distinct lung microbiota associate with HIV-associated chronic lung disease in children

Sudha Bhadriraju
Douglas W. Fadrosh
John Z. Metcalfe
ResearchOpen Access30 Sept 2020
Scientific Reports

Volume: 10, P: 1-9
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

An extensive analysis of HERVH (a primate-specific endogenous retrovirus) expression in human pluripotent stem cells is presented, identifying a sub-population of cells within cultured human embryonic stem cells and induced pluripotent stem cells that has characteristics of naive-state cells — the study provides evidence for a new primate-specific transcriptional circuitry regulating pluripotency.

Jichang Wang
Gangcai Xie
Zsuzsanna Izsvák
Research15 Oct 2014
Nature

Volume: 516, P: 405-409
NF-κB signalling requirement for brain myelin formation is shown by genotype/MRI phenotype correlations in patients with Xq28 duplications

Orianne Philippe
Marlène Rio
Laurence Colleaux
Research18 Jul 2012
European Journal of Human Genetics

Volume: 21, P: 195-199
Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

V Cecchinato
C J Trindade
G Franchini
Research07 May 2008
Mucosal Immunology

Volume: 1, P: 279-288
1045 TRANSMISSION OF CYTOMEGALOVIRUS WITHIN A LARGE NEONATAL INTENSIVE CARE NURSERY

Stuart P Adler
Linda L Laurence
Mary S Wilson
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 285
Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression

Déborah François
Laurence Venisse
Marie-Christine Bouton
Research08 Sept 2014
Laboratory Investigation

Volume: 94, P: 1237-1246
Genetic diversity and pathogenic variants as possible predictors of severity in a French sample of nonsyndromic heritable thoracic aortic aneurysms and dissections (nshTAAD)

Pauline Arnaud
Nadine Hanna
Catherine Boileau
Research11 Feb 2019
Genetics in Medicine

Volume: 21, P: 2015-2024
The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers–Danlos syndrome

Michael Frank
Juliette Albuisson
Xavier Jeunemaitre
Research11 Mar 2015
European Journal of Human Genetics

Volume: 23, P: 1657-1664
The complex tibial organ of the New Zealand ground weta: sensory adaptations for vibrational signal detection

Johannes Strauß
Kathryn Lomas
Laurence H. Field
ResearchOpen Access17 May 2017
Scientific Reports

Volume: 7, P: 1-15
Long-term humoral response following Delta and Omicron BA.1 co-infection

Carla Saade
Bruno Pozzetto
Sophie Trouillet-Assant
ResearchOpen Access20 Apr 2023
npj Vaccines

Volume: 8, P: 1-4
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

John F. Darby
Lewis R. Vidler
Paul Workman
ResearchOpen Access29 Sept 2020
Scientific Reports

Volume: 10, P: 1-13
The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer

Yadong Zhang
Yongju Lu
Fei Chen
Research09 May 2005
Oncogene

Volume: 24, P: 4873-4882
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Antonin Bal
Karen Brengel-Pesce
Martine Valette
ResearchOpen Access22 Jul 2021
Scientific Reports

Volume: 11, P: 1-10
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Publisher Correction: Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Antonin Bal
Karen Brengel-Pesce
Martine Valette
Amendments and CorrectionsOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-2

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