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Showing 1–12 of 12 results

Advanced filters: Author: Laurent Leclercq Clear advanced filters

A glycosylated lipooctapeptide promotes uptake and growth of Mycobacterium abscessus in the host

Leclercq et al report the structure of a glycosylated lipooctapeptide (GL8P) produced by Mycobacterium abscessus. GL8P is shown to induce a strong humoral response in infected patients and to contribute to intramacrophage survival and virulence in mice.

Louis David Leclercq
Vincent Le Moigne
Jean-Louis Herrmann
ResearchOpen Access08 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Sepsis-trained macrophages promote antitumoral tissue-resident T cells

Here the authors show that sepsis and its resolution alter cancer susceptibility by epigenetically altering resident macrophages resulting in retention of T cells that increase antitumoral immunity.

Alexis Broquet
Victor Gourain
Antoine Roquilly
Research29 Apr 2024
Nature Immunology

Volume: 25, P: 802-819
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma

El-Hachem et al. show that MAPK therapy upregulates valine aminoacyl-tRNA synthetase and alters fatty acid oxidation by promoting translation of valine-enriched transcripts, providing a resistance mechanism that may be therapeutically targeted.

Najla El-Hachem
Marine Leclercq
Pierre Close
ResearchOpen Access07 Jun 2024
Nature Cell Biology

Volume: 26, P: 1154-1164
Author Correction: Sepsis-trained macrophages promote antitumoral tissue-resident T cells

Alexis Broquet
Victor Gourain
Antoine Roquilly
Amendments and Corrections07 Oct 2024
Nature Immunology

Volume: 25, P: 2167
Upregulation of ELP3 in acinar cells during acute pancreatitis is dispensable for homeostasis, inflammation, regeneration, and cancer initiation

Elias Aajja
Hélène Lefort
Christophe E. Pierreux
ResearchOpen Access06 Nov 2025
Scientific Reports

Volume: 15, P: 1-14
Inhibition of HECT E3 ligases as potential therapy for COVID-19

Giuseppe Novelli
Jing Liu
Pier Paolo Pandolfi
ResearchOpen Access24 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-18
Database of SARS-CoV-2 and coronaviruses kinetics relevant for assessing persistence in food processing plants

Ngoc-Du Martin Luong
Laurent Guillier
Estelle Chaix
ResearchOpen Access26 Oct 2022
Scientific Data

Volume: 9, P: 1-11
Taylor Dispersion Analysis to support lipid-nanoparticle formulations for mRNA vaccines

Camille Malburet
Laurent Leclercq
Hervé Cottet
Research01 Nov 2022
Gene Therapy

Volume: 30, P: 421-428
T cell apoptosis characterizes severe Covid-19 disease

Sonia André
Morgane Picard
Jérôme Estaquier
ResearchOpen Access22 Jan 2022
Cell Death & Differentiation

Volume: 29, P: 1486-1499
Short-term supplementation of celecoxib-shifted butyrate production on a simulated model of the gut microbial ecosystem and ameliorated in vitro inflammation

Emma Hernandez-Sanabria
Evelien Heiremans
Tom Van de Wiele
ResearchOpen Access19 Feb 2020
npj Biofilms and Microbiomes

Volume: 6, P: 1-12
30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Rishi Singhal
Victor Roth Cardoso
Mehmet Saydam
ResearchOpen Access15 Dec 2021
International Journal of Obesity

Volume: 46, P: 750-757
Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells

F Journe
C Chaboteaux
J-J Body
ResearchOpen Access12 Oct 2004
British Journal of Cancer

Volume: 91, P: 1703-1710