Nature Search

Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids

Here authors used patient-derived forebrain organoids to reveal how LIS1 mutations cause varying severity in a neurodevelopmental disorder, uncovering links between cytoskeletal defects, protein stress, and potential therapeutic strategies.

Lea Zillich
Matteo Gasparotto
Julia Ladewig
ResearchOpen Access13 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus

New treatments for cocaine use disorder (CocUD) require an understanding of the underlying neurobiology. Here, the authors show opposing effects of ZEB1 in CocUD and highlight disrupted synaptic signaling and phosphodiesterase inhibitors as potential therapeutic targets.

Lea Zillich
Annasara Artioli
Stephanie H. Witt
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum

Lea Zillich
Eric Poisel
Stephanie H. Witt
ResearchOpen Access06 May 2022
Translational Psychiatry

Volume: 12, P: 1-9
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder

Eric Zillich
Hanna Belschner
Lea Zillich
ResearchOpen Access09 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-14
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Acute stress induces changes in epigenome-wide DNA methylation

Lea Zillich
Nathaly S. Czernin
Miriam A. Schiele
ResearchOpen Access12 Dec 2025
Neuropsychopharmacology

P: 1-9
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Using a sample of more than 1 million individuals, Hatoum et al. identify genomic loci associated with general and substance-specific addiction risk.

Alexander S. Hatoum
Sarah M. C. Colbert
Arpana Agrawal
Research22 Mar 2023
Nature Mental Health

Volume: 1, P: 210-223
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

A large-scale multi-cohort association study reveals strong and consistent impacts of birth order on DNA methylation events around the genome, potentially due to changes in placentation, nutrition, and growth factors between first and subsequent pregnancies.

Shaobo Li
Natalia Spitz
Joseph L. Wiemels
ResearchOpen Access09 Jan 2024
Communications Biology

Volume: 7, P: 1-11
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Priyanka Choudhary
Giulietta S. Monasso
Sylvain Sebert
ResearchOpen Access05 Dec 2023
Molecular Psychiatry

Volume: 29, P: 348-358
Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome

Katharina Domschke
Miriam A. Schiele
Jürgen Deckert
ResearchOpen Access25 Apr 2025
Molecular Psychiatry

Volume: 30, P: 4529-4542
Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms

Lea Sirignano
Fabian Streit
Jerome C. Foo
ResearchOpen Access21 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
Methylome-wide change associated with response to electroconvulsive therapy in depressed patients

Lea Sirignano
Josef Frank
Jerome C. Foo
ResearchOpen Access05 Jun 2021
Translational Psychiatry

Volume: 11, P: 1-9
Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Doretta Caramaschi
Alexander Neumann
Gemma Sharp
ResearchOpen Access10 Feb 2022
Molecular Psychiatry

Volume: 27, P: 2126-2135
Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness

Fabian Streit
Stephanie H. Witt
Ole A. Andreassen
ResearchOpen Access11 Apr 2022
Translational Psychiatry

Volume: 12, P: 1-8
Epigenome-wide association study of alcohol use disorder in five brain regions

Lea Zillich
Josef Frank
Stephanie H. Witt
ResearchOpen Access13 Nov 2021
Neuropsychopharmacology

Volume: 47, P: 832-839
Evidence for a shared genetic contribution to loneliness and borderline personality disorder

Anna Schulze
Fabian Streit
Stephanie Witt
ResearchOpen Access18 Dec 2023
Translational Psychiatry

Volume: 13, P: 1-8
Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Anna Kotsakis Ruehlmann
Sara Sammallahti
Kelly J. Brunst
Research10 Mar 2023
Molecular Psychiatry

Volume: 28, P: 5090-5100
Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study

Joanna M. Biernacka
Brandon J. Coombes
Victor M. Karpyak
ResearchOpen Access23 Jul 2021
Neuropsychopharmacology

Volume: 46, P: 2132-2139
Real-time individual benefit from social interactions before and during the lockdown: the crucial role of personality, neurobiology and genes

Maximilian Monninger
Pascal-M. Aggensteiner
Nathalie E. Holz
ResearchOpen Access21 Jan 2022
Translational Psychiatry

Volume: 12, P: 1-10
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Sarah M. C. Colbert
Eric T. Monson
Lea Zillich
ReviewsOpen Access25 Sept 2025
Molecular Psychiatry

Volume: 30, P: 6144-6154

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