How α-synuclein interacts with the neuronal cell surface to contribute to disease pathology is not fully understood. Here, the authors conducted a comprehensive search for neuronal membrane proteins mediating α-synuclein aggregate uptake, and identified mGluR4 and NPDC1 as essential for Parkinson’s disease related neurodegeneration triggered by extracellular α-synuclein fibrils.
- Azucena Perez-Canamas
- Mingming Chen
- Stephen M. Strittmatter
