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Showing 1–6 of 6 results
Advanced filters: Author: Leonidas Tsiokas Clear advanced filters

  • Ciliogenesis starts as cells enter quiescence and primary cilium resorption precedes mitosis. The centrosomal protein Nde1 is shown to regulate cilia length during the cell cycle. Loss of Nde1 in zebrafish leads to developmental patterning defects reflecting impaired control of cilium formation.

    • Sehyun Kim
    • Norann A. Zaghloul
    • Leonidas Tsiokas
    Research
    Nature Cell Biology
    Volume: 13, P: 351-360

  • Seokho et al. report that Wnt ligands bind the extracellular domain of polycystin 1 (PKD1) and induce Ca2+ influx through the Ca2+-permeable ion channel TRPP2. This activity is abrogated by PKD1 mutations linked to polycystic kidney disease.

    • Seokho Kim
    • Hongguang Nie
    • Leonidas Tsiokas
    Research
    Nature Cell Biology
    Volume: 18, P: 752-764

  • The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.

    • Prabir K. Chakraborty
    • Soumyajit Banerjee Mustafi
    • Priyabrata Mukherjee
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Petsouki et al. dissect the importance of FBW7-mediated regulation of NDE1 and TALPID3 in mesenchymal stem cells (MSCs). They find that by modulating the abundance of negative (NDE1) and positive (TALPID3) cilia regulators, FBW7 contributes to both the assembly and signaling functions of primary cilia that are necessary for osteoblast differentiation.

    • Eleni Petsouki
    • Vasileios Gerakopoulos
    • Leonidas Tsiokas
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15