ESR1 mutations occur in endocrine-resistant patients but have not yet been reported in in vitro models of breast cancer. Here, the authors report the discovery of naturally occurring ESR1
Y537Cand ESR1
Y537S mutations in two breast cancer cell lines after acquisition of resistance to long-term-estrogen-deprivation.
- Lesley-Ann Martin
- Ricardo Ribas
- Mitch Dowsett
