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Showing 1–4 of 4 results
Advanced filters: Author: Letong Wang Clear advanced filters

  • Pyroptosis is a programmed cell death mechanism relevant in cancer therapy that can be triggered by endocytic organelle stress, but is challenging to induce in a controlled manner. In this paper the authors engineer a library of ultra-pH-sensitive nanophotosensitizers that can target specific endocytic organelles and elicit pyroptotic cancer cell death in a controlled fashion.

    • Binlong Chen
    • Yue Yan
    • Yiguang Wang
    Research
    Nature Nanotechnology
    Volume: 17, P: 788-798

  • Small Cas enzymes are required for therapeutic use. Here the authors report an Interaction, Dynamics and Conservation (IDC) strategy for protein miniaturisation and use this to generate five compact variants of Cas13 based on a combination of IDC strategy and AlphaFold2.

    • Feiyu Zhao
    • Tao Zhang
    • Zhanjun Li
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13