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Overcoming parasitic reactions between the electrolyte and electrodes is essential for realizing energy-dense lithium metal batteries. Here, the authors develop an oxygen distal fluorinated diluent that promotes a diluent- and anion-rich solvation structure, forming a stable inorganic-rich interphase and stable cycling in pouch cells at 500 Wh kg^–1 level.

The work presents a method to design grounded metamaterials whose displacement response remains unchanged under microstructure and shape reconfiguration, demonstrated experimentally using structures with tailored, mapping-invariant deformation behaviours.

After deep-space flight, rice seeds show increase in mutations and alteration in DNA and RNA modifications. Multi-omics and single-cell analyses suggest a transcription factor named SVT1 suppresses the differentiation of mutation-carrying cells via the MAPK pathway.

Reverse-bias degradation limits the reliability of perovskite modules, especially under shading. The authors introduce an S-β-CD iodine-chelating layer at the SnO₂/perovskite interface to block the decay pathway and greatly boost operational and reverse-bias stability.

Chen et al. report a strategy of separating dipping and coating processes for fabricating highly conductive and comprehensive wearable graphene electronic fabrics. This low-cost methodology achieves 200-meter roll mass production, offering a universal platform for next-generation wearable technologies.

The authors report a resonant inelastic x-ray scattering study of superconducting Sm-based infinite-layer nickelate thin films. Despite the two-fold enhancement of T_c in the Sm-based nickelates compared to their Pr-based counterparts, they find that the effective in-plane exchange coupling strength is reduced by approximately 20%.

Telomeric systems are conserved across eukaryotes and may have originated over 1 billion years ago. Here the authors replaced yeast’s telomeres with a bacterial virus system, resulting in a stable functional assembly of DNA molecules up to 2.77 Mb, offering insights into the possible origins of telomeres.

Atherosclerotic carotid stenosis leads to stroke, but how perivascular adipose tissue (PVAT) drives plaque instability is poorly understood. Here the authors show that PVAT harbours distinct ADSC subsets, with CD55⁺ADSCs promoting plaque angiogenesis via FGF2 and CXCL14⁺ADSCs enhancing inflammation, driving plaque destabilization.

Researchers develop a swellable polymer platform that immobilizes photocatalysts into flexible films and enables three-dimensional stacking architectures, boosting solar-driven hydrogen production and increasing energy output per unit area.

Maternal obesity is a risk factor for developing chronic kidney disease in the offspring later in life. Here the authors study male offspring in a mouse model of maternal obesity and identify dysregulated metabolism due to disrupted crosstalk between proximal tubules and macrophages as an important mechanism.

The electrochemistry-mechanics performance relationship in Zn||MnO₂ cells is not extensively revealed. Here, authors shed light on the electrochemomechanical interplay of Zn||β-MnO₂ pouch cells with different electrolytes via optical fiber sensors, offering additional tools for electrolyte screening and battery design.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Btg2 suppresses UFMylation of Fmo1, promoting its k48-linked ubiquitination and degradation, thereby restricting taurine synthesis and exacerbating ferroptosis and apoptosis in hepatic ischemia-reperfusion injury.

CNS injury disrupts neural circuits, with poor regeneration due to HDAC retention and hostile environments. Here, the authors show a nanosystem with LMK-235 that forms electroactive scaffolds and promotes regeneration and enhances synaptic reconnection

Oxidative stress and dsRNA are key drivers of skin inflammation, while therapies targeting oxidative stress are common, dsRNA targeting is not. Here, the authors report on a cerium-doped polyoxometalate with anti-oxidative and dsRNA binding properties showing potential for a transdermal strategy to reduce skin inflammation.

Traditional routes to conjugated polymers utilize C–C cross couplings, requiring expensive metal-based catalysts and oxygen free conditions. Here, the authors describe a click-like Aldol polycondensation route, enabling the rapid synthesis of conjugated polymers under mild, oxygen tolerant conditions using Lewis acid catalysts.

Excess free fatty acids are toxic to cells. Here, the authors identify TMEM120A as a GPAT4 activator that promotes the incorporation of medium- and long-chain fatty acids into glycerolipids to prevent lipotoxicity.

Climate heterogeneity strongly shapes how vegetation responds to environmental change, but is often overlooked in large-scale modelling. This study shows that incorporating climate heterogeneity improves vegetation suitability predictions, especially at coarse spatial resolutions.

Self-healing materials typically suffer from poor mechanical properties due to the inherent trade-off between mechanical robustness and self-healing capability. Here the authors report a composite featuring an aligned array of hydroxyapatite nanowires interwoven with dynamic borate bond networks by a bidirectional freeze-drying method.

Early embryogenesis requires translational control which can be regulated through tRNA levels. Here, the authors develop ORACLE-tRNAseq to map dynamic tRNA landscapes across mouse preimplantation stages and find tRNA regulation coinciding with genome activation and coupled to translational coordination.

Spatial transcriptomics platforms span multicellular to subcellular resolutions but lack methods to reconstruct single-cell transcriptomes across them. Here, the authors introduce STARS, a unified deep learning framework that integrates histology and transcriptomics to infer single-cell gene expression across resolutions.

Wide-bandgap perovskites offer promise for tandems but suffer from formation-pathway instabilities. Huang et al. use in-situ analysis to guide CsPbX₃ intermediate evolution, enabling uniform α-phase formation and high-efficiency, stable devices.

The study develops a lightweight vision model for monitoring transmission lines, integrating hazard detection, depth transformation, pose estimation, and point cloud structure sparsification to enhance real-time hazard detection and distance measurement, validated in diverse terrains and weather conditions.

Polymeric nanoparticles are promising non-lipid-based drug delivery vehicles. However, their clinical translation is limited by poor drug loading capacity and suboptimal delivery efficiency. Here, the authors address these issues by developing Polymeric Coacervate Core Micelles that can efficiently self-assemble and load drug candidates via a “Mix-and-Go” approach.

The authors show that crystal anisotropy can guide nanoscale wrinkles on rigid chip substrates at room temperature, turning hard dielectrics into tunable, aligned patterns that diffract light and could support future on-chip photonic devices.

Ni-decorated LiBH₄ nanocomposites achieve room-temperature hydrogenation of boron, enabled by synergistic catalysis and nanostructuring that promotes H₂ dissociation and B–H bond formation, a key step for practical hydrogen storage systems.

Model building in cryo-EM strongly depends on its map quality. Here, the authors propose EMReady2, a generalist tool for fast improvement of cryo-EM and cryo-ET maps at 2–10 Å resolutions with local quality-aware deep learning.

Prevalent recycling technologies focus on processing only one type of spent cathode material, demanding high energy input and significant chemical consumption. Here, authors present a redox‑mediated flow‑cell strategy to recover multiple cathode types, generating electricity during the process, with >95% metal leaching efficiency.

Nasopharyngeal carcinoma (NPC) screening in southern China uses EBV serology, but its positive predictive value is low. Here, the authors introduce a swab-based E-CpMQ method in high-risk individuals, achieving better specificity.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Cobalt catalysts turn carbon monoxide into fuels, but their active surface structure has been uncertain. This study identifies an actual cobalt surface structure and shows it changes how carbon monoxide reacts.

This study examines severe lattice distortions in concentrated solid solutions, enabling an energy landscape that immobilizes vacancies and interstitials which curbs their harmful evolution under irradiation conditions.

Superionic conductors are typically engineered from static crystal structures. Here, authors present how flexible polyanion rotations induce dynamic disorder in lithium sublattice, enabling liquid-like ion diffusion and enhanced ionic conductivity.

Designing efficient high entropy catalysts is highly desired but remains challenging. Here, the authors report the spin state engineering to develop high-entropy Ruddlesden Popper perovskite oxides for efficient seawater splitting, with the strategy applicable to other high entropy catalysts.

The authors developed biodegradable meta-membranes that regulate the skin microenvironment, self-decontaminate, and maintain high air purification efficiency even under humidity were developed, offering a sustainable solution for personal protective equipment.

This study highlights a strategy to additively manufacture lightweight, strong, and ductile heat-resistant aluminum alloys. The partial solid-state amorphization of the nanoprecipitates during high-temperature tension offers an additional toughening mechanism.

Amorphous chalcogenides enable ultrafast threshold switching, yet their switching mechanism remains debated between electronic and structural models. Song et al. reveal an electric field induced atomic displacement and dipolar ordering, which exhibit a non-Arrhenius structural transition and guide conductive filament formation.

Environmental Li pollution and health problems have been becoming an important concern worldwide. Here, the authors show that Li exposure causes trophoblast cell ferroptosis and thus induces unexplained miscarriage through a non-canonical MBOAT1 pathway.

Despite several experimental studies, implementing sensing platforms based on non-Hermitian exceptional points remains challenging. Here, the authors introduce a programmable digital electronic unit design within a non-Hermitian atomic magnetometer, overcoming technical limitations and showing enhanced sensing.

Biomass electro-hydrogenation offers a sustainable route to value-added chemicals but suffers poor selectivity at high current densities. Here, the authors report an amide-functionalized Cu₃N catalyst enabling near-quantitative HMF-to-DHMF conversion under industrially relevant conditions.

In zebrafish, cholecystokinin drives gonadal development via two parallel pathways: direct FSH stimulation in the pituitary and local regulation of germ cell proliferation and survival within the gonad.

Conventional Si-based physical unclonable functions (PUFs) are normally limited by limited entropy and lack of reconfigurability, exposing them to machine learning attacks. Here, the authors report optically reconfigurable PUFs based on 2D MoS₂ ring-oscillator arrays, demonstrating machine-learning-attack-resistant image encryption.

The development of organo-catalyzed C(sp²)–O functionalization has gained significant importance in modern synthetic chemistry. Here, the authors report an organo-catalyzed enantioselective formal C(sp²)–O/O–H cross metathesis using alcohols as nucleophiles and boron dipyrromethene dyes as substrates.

Here, the authors show that uridine enhances oocyte quality in aged mice by binding to PCBP1 to suppress ferroptosis and preserve mitochondrial function, suggesting a potential strategy to delay female reproductive aging.

Grain number per panicle (GNP) is a critical yield component trait of rice. Here, the authors clone a MAPKKK encoding gene GNP3 positively regulating grain yield and show its role in rice panicle development by interacting and destabilizing ethylene biosynthesis related enzyme SADENOSYLMETHIONINE SYNTHETASE 1.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

In this work, researchers identify a selective inhibitor of the urea transporter UT-A2 using hotspot pocket–based virtual screening combined with cryo-EM and pharmacological methods, thereby providing an efficient approach for developing UT-A-selective inhibitors as next-generation diuretics.

Abdominal aortic aneurysm (AAA) is a life-threatening condition, but its underlying mechanisms are unclear. Here, the authors show that PDK4 contributes to abdominal aortic aneurysm by promoting metabolic reprogramming in vascular smooth muscle cells, leading to activation of NLRP3.

A room-temperature ferroelectricity with out-of-plane polarization is disclosed in chemical vapor deposition synthesized two-dimensional α-MnS, which exhibits large tunneling electroresistance, high endurance, and long retention time.