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Acta Pharmacologica Sinica (26)
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Showing 1–50 of 53 results

Advanced filters: Author: Li Ou-yang Clear advanced filters

SARS-CoV-2 infection during the first trimester leads to profound immune dysregulation at the maternal-fetal interface despite limited virus detection in placental tissues

Despite the global prevalence of SARS-CoV-2 infection, its maternal–fetal interface during the first trimester remains underexplored. Here, the authors combined a cohort of 700+ samples and determine that maternal SARS-CoV-2 infection in the first trimester rarely infects placental tissue but alters immune responses and cellular communication, which may influence pregnancy outcomes.

Xian-Xian Liu
Xuejuan Shen
Yongyi Shen
ResearchOpen Access13 Apr 2026
Nature Communications

P: 1-13
ZNRF1 deficiency disrupts Fas ligand trafficking and immune balance

Ting-Yu Lai
Yung-Chi Chang
Chih-Yuan Lee
ResearchOpen Access28 Mar 2026
Cell Death & Disease

P: 1-13
Bulk Crystallization Behavior of Poly(ε-caprolactone) with a Wide Range of Molecular Weight

Wen-Chung Ou-Yang
Lain-Jong Li
Jenn Chiu Hwang
Research01 Nov 1997
Polymer Journal

Volume: 29, P: 889-893
Intraarterial microbubble delivery enhances focused ultrasound induced blood brain barrier opening in the murine substantia nigra

Hsun Li
Yung-Han Lee
Chin-Hsien Lin
ResearchOpen Access29 Nov 2025
Scientific Reports

Volume: 16, P: 1-14
Th17/Treg cell imbalance in allergic rhinitis: mechanisms and therapeutic implications

Ye Xiong
Fei Wang
Zhenhua Zhu
ReviewsOpen Access05 Mar 2026
Genes & Immunity

Volume: 27, P: 157-172
Sophocarpine alleviates chronic itch in mouse atopic dermatitis by inhibiting spinal astrocyte reactivity and pro-inflammatory signaling

Meng-ping Lou
Xin-yi Gao
Wen-li Mi
Research07 Jan 2026
Acta Pharmacologica Sinica

Volume: 47, P: 876-887
3-Acetyl-oleanolic acid ameliorates non-alcoholic fatty liver disease in high fat diet-treated rats by activating AMPK-related pathways

Qiong Ou-Yang
Chun-xiao Xuan
Jun Liu
Research18 Jan 2018
Acta Pharmacologica Sinica

Volume: 39, P: 1284-1293
Single-cell RNA sequencing dissects the immunosuppressive signatures in Helicobacter pylori-infected human gastric ecosystem

Helicobacter pylori (H. pylori) establishes chronic infection in human, but the underlying mechanistic insights are lacking. Here the authors use single cell RNA and TCR sequencing to profile peripheral blood and mucosal cells from infected patients to report alterations in macrophage differentiation and T cell gene signature that may contribute to persisting H. pylori infection.

Wei Hu
Ze Min Chen
Wei Gong
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-16
The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis

Wen-bin Xu
Li-hui Xu
Xian-hui He
Research13 Apr 2009
Acta Pharmacologica Sinica

Volume: 30, P: 597-604
Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBC1D4 phosphorylation

Jian Liu
Jing-fang Zhang
Jing-ping Ou-yang
Research29 Oct 2012
Acta Pharmacologica Sinica

Volume: 34, P: 137-145
New Potassium Sodium Niobate Single Crystal with Thickness-independent High-performance for Photoacoustic Angiography of Atherosclerotic Lesion

Benpeng Zhu
Yuhang Zhu
Wei Wei
ResearchOpen Access21 Dec 2016
Scientific Reports

Volume: 6, P: 1-8
Adipocyte-driven STAT3-ANGPT2-PTGIS axis promotes cutaneous metastasis in breast cancer and represents a targetable pathway

Chi-Wen Luo
Fu Ou-Yang
Mei-Ren Pan
ResearchOpen Access06 Feb 2026
npj Precision Oncology

Volume: 10, P: 1-13
A linear and circular dual-conformation noncoding RNA involved in oxidative stress tolerance in Bacillus altitudinis

The presence and/or biological functionality of circular RNAs in bacteria are unclear. Here, the authors identify a dual-conformation (linear and circular) noncoding RNA that promotes tolerance to oxidative stress in Bacillus altitutidinis, and provide evidence for the existence of other circular RNAs in diverse bacterial species.

Ting-Ting He
Yun-Fan Xu
Hai-Yan Wang
ResearchOpen Access15 Sept 2023
Nature Communications

Volume: 14, P: 1-14
Carnosine suppresses oxygen-glucose deprivation/recovery-induced proliferation and migration of reactive astrocytes of rats in vitro

Li Ou-yang
Yuan Liu
Jian-xin Lyu
Research21 Sept 2017
Acta Pharmacologica Sinica

Volume: 39, P: 24-34
Co-activation of nAChR and mGluR induces γ oscillation in rat medial septum diagonal band of Broca slices

Ya-li Wang
Jian-gang Wang
Cheng-biao Lu
Research06 Jan 2014
Acta Pharmacologica Sinica

Volume: 35, P: 175-184
The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics

The mammalian subcortical maternal complex is composed of maternally expressed proteins and required for mouse early embryonic cell division. Here the authors show that the complex functions to control spindle positioning through regulation of the actin cytoskeleton.

Xing-Jiang Yu
Zhaohong Yi
Lei Li
Research11 Sept 2014
Nature Communications

Volume: 5, P: 1-12
Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca²⁺ oscillations on hippocampal neurons

Shao-qing Zhu
Lei Qi
Zuo-ping Xie
Research01 Jan 2008
Acta Pharmacologica Sinica

Volume: 29, P: 57-64
Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine

Yu-xia Zhang
Shi-bin Yu
Jin-rong Li
Research01 Nov 2005
Acta Pharmacologica Sinica

Volume: 26, P: 1365-1372
Explaining basketball game performance with SHAP: insights from Chinese Basketball Association

Yan Ou-Yang
Wei Hong
Yu-Fan Wang
ResearchOpen Access21 Apr 2025
Scientific Reports

Volume: 15, P: 1-19
The influence of a caveolin-1 mutant on the function of P-glycoprotein

Chih-Yuan Lee
Ting-Yu Lai
Jin-Shing Chen
ResearchOpen Access04 Feb 2016
Scientific Reports

Volume: 6, P: 1-9
Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry

Xiao-fen Li
Yi-ping Wang
Research01 Jun 2007
Acta Pharmacologica Sinica

Volume: 28, P: 789-795
Complex regulatory networks influence pluripotent cell state transitions in human iPSCs

Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Here, authors show that pluripotency and self-renewal processes have a high level of regulatory complexity and suggest that genetic factors contribute to cell state transitions in human iPSC lines.

Timothy D. Arthur
Jennifer P. Nguyen
Kelly A. Frazer
ResearchOpen Access23 Feb 2024
Nature Communications

Volume: 15, P: 1-19
Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons

Ou-Yang Zhanmu
Yang Yang
Man Li
Research11 Dec 2024
Acta Pharmacologica Sinica

Volume: 46, P: 904-921
Non-Hermitian physics for optical manipulation uncovers inherent instability of large clusters

Non-conservativeness plays a mysterious role in optical trapping. Applying the non-Hermitian theory, the authors showed that the existence of exceptional points drives the Lorentz force to lose its ability to bind clusters of ~10 or more microparticles, unless remedied by dissipative forces.

Xiao Li
Yineng Liu
C. T. Chan
ResearchOpen Access15 Nov 2021
Nature Communications

Volume: 12, P: 1-9
Pregnane X receptor alleviates sepsis-induced liver injury through activation of yes-associated protein in mice

Cheng-hua Wu
Shuang Hu
Hui-chang Bi
Research15 Apr 2025
Acta Pharmacologica Sinica

Volume: 46, P: 2423-2435
Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

Ming-Feng Hou
Fu Ou-Yang
Chih-Po Chiang
ResearchOpen Access27 Oct 2021
Experimental & Molecular Medicine

Volume: 53, P: 1636-1646
Whole-exome sequencing reveals novel genomic signatures and potential therapeutic targets during the progression of rectal neuroendocrine neoplasm

Shi Xu
Zhi Yong Zhai
Wei Hu
ResearchOpen Access15 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-12
Effects of nicotine stimulation on spikes, theta frequency oscillations, and spike-theta oscillation relationship in rat medial septum diagonal band Broca slices

Dong Wen
Ce Peng
Cheng-biao Lu
Research11 Mar 2013
Acta Pharmacologica Sinica

Volume: 34, P: 464-472
Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells

Sheng Hu
Shi-min Chen
Zhi-nan Mei
Research01 Aug 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1215-1223
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis

Jie Tong
Xiu-ting Lan
Dong-jie Li
Research02 Nov 2022
Acta Pharmacologica Sinica

Volume: 44, P: 1014-1028
Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis

Fu-li Shi
Qing Li
Dong-yun Ou-yang
Research14 Nov 2023
Acta Pharmacologica Sinica

Volume: 45, P: 594-608
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

Yinghao Sun and colleagues report a genome-wide association study for prostate cancer in Han Chinese men. They identify two new risk-associated loci at chromosomes 9q31 and 19q13.

Jianfeng Xu
Zengnan Mo
Yinghao Sun
Research30 Sept 2012
Nature Genetics

Volume: 44, P: 1231-1235
Unveiling spatial domains from spatial multi-omics data using dual-graph regularized ensemble learning

SMODEL integrates spatial multi-omics data through dual-graph-regularized ensemble learning to robustly detect spatial domains, revealing tissue architecture and cellular heterogeneity.

Ying Li
Guangchang Cai
Le Ou-Yang
ResearchOpen Access20 Jun 2025
Communications Biology

Volume: 8, P: 1-14
Molecular mechanisms of adenosine-induced apoptosis in human HepG2 cells

Ling-fei Wu
Guo-ping Li
Ze-jin Pu
Research01 Apr 2006
Acta Pharmacologica Sinica

Volume: 27, P: 477-484
Ca²⁺ sparks and Ca²⁺ glows in superior cervical ganglion neurons

Li-jun Yao
Gang Wang
He-ping Cheng
Research01 Jul 2006
Acta Pharmacologica Sinica

Volume: 27, P: 848-852
Minimal contribution of IP₃R2 in cardiac differentiation and derived ventricular-like myocytes from human embryonic stem cells

Peng Zhang
Ji-jun Huang
Huang-tian Yang
Research09 Oct 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1576-1586
Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages

Yi-ping You
Liang Yan
Xian-hui He
Research02 Sept 2024
Acta Pharmacologica Sinica

Volume: 46, P: 430-447
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction

Xiu-xiu Wang
Yi-ming Zhao
Yu Liu
Research05 Jun 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1425-1437
Further evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese

S P Hu
N E Day
B A J Ponder
ResearchOpen Access22 Feb 2005
British Journal of Cancer

Volume: 92, P: 967-970
Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly

Si-yuan Chen
Ya-ping Li
Xian-hui He
Research23 May 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2019-2036
The crosstalk between endothelial cells and vascular smooth muscle cells aggravates high phosphorus-induced arterial calcification

Xiao Lin
Su-Kang Shan
Ling-Qing Yuan
ResearchOpen Access26 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-15
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth

Qing-yong Hu
Lei Li
Yang Cao
Research09 Oct 2024
Acta Pharmacologica Sinica

Volume: 46, P: 740-750
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1

Jing-yu Weng
Xin-xing Chen
Yi-fang Li
Research16 May 2023
Acta Pharmacologica Sinica

Volume: 44, P: 1856-1866
Weighing the future: strategic measures against rising childhood obesity

Xu Ou-Yang
Guochao Zhang
Hang Yi
Comments & Opinion08 Oct 2024
Pediatric Research

Volume: 97, P: 1795-1797
Response analysis of host Spodoptera exigua larvae to infection by Heliothis virescens ascovirus 3h (HvAV-3h) via transcriptome

Huan Yu
Zi-Qi Li
Guo-Hua Huang
ResearchOpen Access29 Mar 2018
Scientific Reports

Volume: 8, P: 1-16
Use of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis

Teng-Hui Wu
Jing Peng
Fang He
ResearchOpen Access14 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury

Ke Lu
Si-Yu Shen
Bin Xue
ResearchOpen Access22 Nov 2022
Cell Death & Disease

Volume: 13, P: 1-13
Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways

Chun-su Zhong
Bo Zeng
Xian-hui He
Research10 Aug 2021
Acta Pharmacologica Sinica

Volume: 43, P: 1324-1336
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice

Dan-yang Zhu
Jian Lu
Xu Shen
ResearchOpen Access08 Mar 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2495-2510
Behaviors of Glioblastoma Cells in in Vitro Microenvironments

Wenwen Diao
Xuezhi Tong
Zhong-Can Ou-Yang
ResearchOpen Access14 Jan 2019
Scientific Reports

Volume: 9, P: 1-9

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