Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Liesbeth Hoekman Clear advanced filters

  • PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

    • Sarah C. Moser
    • Anna Khalizieva
    • Jos Jonkers
    Research
    Nature
    Volume: 645, P: 1071-1080

  • Ubiquitin system factors are critical regulators of DNA repair pathways. Through a functional genetic screen, the authors identify a novel role of ubiquitin-conjugating enzyme UBE2D3 in promoting DNA repair at deprotected telomeres by limiting the accumulation of RNF168 and promoting ample ATM-dependent phosphorylation of KAP1.

    • Zeliha Yalçin
    • Shiu Yeung Lam
    • Jacqueline J. L. Jacobs
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Intestinal stem cells are responsible for replenishing cells within the high-turnover intestinal epithelium. Here they show that ribosome dynamics affect intestinal stem cell identity through a mechanism that is triggered by changes in nutrient availability.

    • Joana Silva
    • Ferhat Alkan
    • William James Faller
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • MAD2L2 — a member of the shieldin complex — is known to play important roles in DNA repair. Here the authors demonstrate how MAD2L2 dimerization mediated through SHLD2 participates in shieldin assembly and function.

    • Inge de Krijger
    • Bastian Föhr
    • Jacqueline J. L. Jacobs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Glucocorticoids (GC) are reported to block cancer cell proliferation, but the mode of action is unclear. Here the authors show that glucocorticoid receptor activation induces cancer cell dormancy in lung cancer by regulating CDKN1C expression through a distal enhancer, and these dormant cells are addicted to IGF-1R signalling pathway.

    • Stefan Prekovic
    • Karianne Schuurman
    • Wilbert Zwart
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Combined analysis of new genomic data from 116 ancient hunter-gatherer individuals together with previously published data provides insights into the genetic structure and demographic shifts of west Eurasian forager populations over a period of 30,000 years.

    • Cosimo Posth
    • He Yu
    • Johannes Krause
    ResearchOpen Access
    Nature
    Volume: 615, P: 117-126

  • The authors study the role of TRIM33 in androgen receptor (AR) transcriptional activity. They show that TRIM33 and AR co-occupy most of their genomic binding sites and TRIM33 loss altered expression of a subset of AR-responsive genes.

    • Nils Eickhoff
    • Janina Janetzko
    • Wilbert Zwart
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-13