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Direct spectroscopic evidence shows that amorphous ice crystallization produces a transient excess of dangling OH bonds, revealing a nonequilibrium surface state that may enhance chemical reactivity in planetary and interstellar ices.

Authors develop a general paradigm combining fluorescence resonance energy transfer imaging, gel electrophoresis and mass spectrometric analysis to identify and quantify intracellular N-acetylglucosamine modified glycoRNAs.

Here they show that TGFβ signaling drives dural cell migration into the coronal suture to maintain its patency. Disruption of this process impairs coronal suture stem cell homeostasis and leads to craniosynostosis, explaining the preferential involvement of the coronal suture in syndromic craniosynostosis.

Alkene 1,1- difunctionalization holds significant importance in organic synthesis due to its ability to effectively enhance the complexity and functionality of molecular frameworks. Here, the authors report an electrochemical strategy for 1,1-difunctionalization of halogenated aromatics with unactivated alkenes, using synergistic Fe/Ni catalysis.

Organic afterglow mechanisms remain debated in carbazole-based analog-doped materials. The authors show afterglow is dominated by guest phosphorescence from deep triplet traps, while carrier traps contribute only weak long-persistent luminescence.

Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems.

Self-assembled monolayers struggle to uniformly coat textured surfaces, limiting high-efficiency perovskite and silicon tandem solar cells. Du et al. increase surface hydroxyl groups by incorporating carbon into polysilicon, enabling stable monolayer attachment and record device efficiency.

Single-cell Hi-C contact maps reveal diverse DNA folding across cells, but data are sparse due to biological mechanism and low sequencing depth. Here, authors introduce structural-zero-aware dissimilarity measures that separate true contact absence from missing data, enhancing cell type clustering.

The arrestin-mediated regulation of signaling through the metabotropic glutamate receptors (mGlus) is fundamental for synapse function. Here, authors report multiple subtype-dependent arrestin binding modes of the mGlus that account for their differential signaling profiles.

Turning lignin oils into nylon ingredients is hard because key bonds resist breaking and products overreact. A light-driven catalyst makes cyclohexanones without added hydrogen and enables tougher, clearer polyamides.

Lin et al. identify a mechanism by which swimming exercise attenuates cognitive decline in Alzheimer’s disease mice, via induction of skeletal muscle-derived vesicles containing miR-378a-3p, taken up by microglia to regulate metabolism and enhance plaque clearance.

All-inorganic perovskite solar cells promise strong stability but still suffer from moisture-driven surface damage and limited efficiency. Zhang et al. form a one-dimensional/three-dimensional interface using a tailored salt to stabilize the material and boost performance.

Four-dimensional printing methods are promising for soft actuators, but existing methods limit programmable molecular alignment to two dimensions. Here the authors report a diffusion-guided two-photon polymerization strategy achieving true volumetric 3D microprinting of liquid crystal network microactuators, enabling complex actuation.

Here, the authors show that the interplay of oxygen vacancies and erbium emitters in bismuth oxyhalides enables reversible, high-contrast switching of upconversion emission, offering a new strategy for high-level anticounterfeiting.

Molecular characteristics of amniote lineages can inform evolutionary inference. Here, the authors present a single-cell RNA-sequencing atlas of the chicken, which is applied to compare immune cells of chicken, turtle, duck and human, determining similarities and distinctions across amniote immune system evolution.

Here, the authors identify ten morphogroups of dermal denticles across extant shark species and quantify their mechanical properties and material composition alongside swimming performance, linking these traits to distinct ecological niches.

Changhua County, Taiwan launched a hepatitis C elimination initiative which integrates population-based screening and targeted strategies for high-risk groups. Here, the authors evaluate its impacts on hepatitis C virus cascade care and treatment outcomes and compare to a counterfactual scenario without the program.

How co-invading species facilitate one another remains largely unknown. This study shows that facilitation is often asymmetric and increases when co-invading plants differ in competitiveness and their ability to shape microbial communities.

Owing to the lack of precise atomic-level control offered by existing fabrication techniques over the edge structures in bilayer graphene, experimental studies on the edge effects in bilayer graphene structures have so far largely remained unexplored. Here the authors synthesize two fully cove-edged bilayer nanographenes and demonstrate their application in NIR-II bioimaging.

Tinengotinib is a spectrum-selective multi-kinase inhibitor targeting several oncogenic and immunoregulatory pathways, including FGFR1–3, JAK1/2, VEGFRs, and Aurora A/B kinases. Here the authors report the results of a phase Ib/II trial of tinengotinib as monotherapy or combined with anti-PDL1 atezolizumab in patients with advanced solid tumors.

Water electrolysis crucially converts fluctuating renewables to green hydrogen. Here, the authors collaborate architecture modulation of anion exchange membrane and pressure configuration design, realizing compatibly improved electrochemical performance and operational flexibility.

The role of RNA-binding protein (RBP) phase separation in transcriptional regulation and its contribution to tumorigenesis remains to be characterised. Here, the authors show that RBP AKAP95 physically co-condenses with the mixed lineage leukemia 1 (MLL1) translocated fragment commonly found in MLL rearranged (MLLr) leukemia to promote leukemogenesis.

Precise transcription-repair coordination is required for efficient DSB repair. Here, the authors show that DNA-PK-mediated CRTC2 Ser433 phosphorylation, relocates DNA-PK from transcription to repair complexes and promote NHEJ. Inhibition of CRTC2 sensitizes liver cancer to radioimmunotherapy.

Strain-induced signal interference limits the reliability and functionality of electronic textiles in deformable environments. Here, the authors present a strain-programmable fiber with tunable resistance responses via a controlled liquid-metal network reconfiguration for anti-interference electronic textiles.

Triple-negative breast cancer brain metastases present a significant clinical challenge. Here, the authors show that targeting the complex I protein NDUFB9 selectively inhibits tumor growth in the brain.

This study reports real-space, layer-resolved magnetic imaging of the van der Waals antiferromagnet (Fe,Co)₃GaTe₂ using SPLEEM, revealing A-type interlayer coupling, intrinsic chiral spin textures and enabling controlled writing of antiferromagnetic skyrmions.

The authors show that crystal anisotropy can guide nanoscale wrinkles on rigid chip substrates at room temperature, turning hard dielectrics into tunable, aligned patterns that diffract light and could support future on-chip photonic devices.

A Spectral Contrastive-Aware Network decodes Zhurong, OMEGA, and CRISM SWIR data, revealing altitude-dependent manganese (hydr)oxide enrichments forming shoreline ‘bathtub rings’ tracing 0.8–1.5-million-year ocean evolution in Utopia Planitia, Mars.

The study presents a planner-initiated framework for siting data centers, integrating reliability screening and market-impact assessment. It expands feasible locations by 9-21% when accounting for operational flexibility and reduces interconnection time by 3.5-4 years, while maintaining stable prices and reducing peak-hour price dispersion.

Electronic skins are promising for wearable electronics, though existing fabrication methods have unfavorable processes and mechanical properties. Here the authors utilize a dipping-dipping molecular assembly to fabricate an E-skin in seconds.

Accurately perceiving object softness remains challenging for tactile sensors. Here, the authors present a tactile sensor that quantitatively and accurately detects both Young’s modulus and Poisson’s ratio.

Memory loss reflects failure of the engram, the cell ensemble that stores memory. Here, the authors show that site-specific phosphorylation of tau, a protein associated with Alzheimer’s disease, coordinates activity of cells linked to long-lasting memories in mice.

Immune checkpoint inhibitors combined with chemotherapy have demonstrated significant benefits in treating triple-negative breast cancer (TNBC). In this study, the authors present results from a randomized phase II trial evaluating the platinum-based and DNA-damaging agent carboplatin in combination with nivolumab in patients with metastatic TNBC.

Researchers develop a swellable polymer platform that immobilizes photocatalysts into flexible films and enables three-dimensional stacking architectures, boosting solar-driven hydrogen production and increasing energy output per unit area.

CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

LTBP4 is associated with heart failure (HF), but its specific role remains unclear. Here, the authors show that LTBP4 is upregulated in HF and drives NLRP3 inflammasome activation in cardiomyocytes via promoting NLRP3-NEK7 interaction, thus serving as a potential therapeutic target for HF.

This research reveals that platelet infiltration initiated by the platelet HuR-PSPF regulatory process coordinates systemic aging. Targeting platelet HuR may be a promising strategy for anti-aging interventions

Background motion profoundly impacts visual perception. Here, the authors show that an inhibitory brainstem pathway, recruited by global background motion, suppresses superior colliculus activity and visual perception mediated by this structure.

Tang et al. demonstrate that disease progression in Duchenne muscular dystrophy is driven not only by dystrophin deficiency but also by ANXA11-mediated failure of regenerative myofiber maturation. Targeting ANXA11 improves muscle regeneration and function in mdx mice.

Decreased intestinal barrier integrity contributes to progression of digestive system tumors. Here the authors report the design and characterization of enterocyte-mimetic butyrate-loaded nanoparticles, showing reduced disruption of the intestinal barrier and inhibited tumor progression after oral delivery.

DNA replication initiation requires precise MCM2-7 assembly. Here, the authors reveal cryo-EM structures of human MCM2-7 showing unique roles of its C-terminal extensions, defining how flexible yet accurate helicase loading ensures genome-wide replication initiation.

Maternal obesity is a risk factor for developing chronic kidney disease in the offspring later in life. Here the authors study male offspring in a mouse model of maternal obesity and identify dysregulated metabolism due to disrupted crosstalk between proximal tubules and macrophages as an important mechanism.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Fe-based Prussian blue positive electrodes for sodium-ion batteries often suffer from stability issues. Here, the authors establish an alkali metal-site selection principle involving Cs⁺ ions to enhance structural stability, enabling long-life positive electrodes with performance further validated in a pouch cell.

Portal fibrosis, a hallmark of progression in chronic liver diseases, typically develops following biliary injury. This study identifies Clec3b⁺ fibroblasts as key drivers of liver portal fibrosis and demonstrates that a KLF4/periostin signaling axis controls their activation, highlighting potential therapeutic targets for inhibiting fibrosis in biliary diseases.

This study achieves ultrafast all-electrical perpendicular magnetization switching with a pulse width of 16 ps and an energy consumption of 41 fJ/bit in a CoTb/Ti/CoFeB/MgO heterostructure, enabled by combining the in-plane and out-of-plane spin current.

Dynamic encirclement of exceptional points (EPs) has so far been reported for chiral, direction dependent mode switching due to non-adiabatic transitions. Here, authors experimentally demonstrate EP encircling related to restored adiabaticity and symmetric state transfer, by modulating polarisation in a two-mode photonic platform.