A 10-year follow-up study of the HPV-16/18 bivalent vaccine shows that vaccination alters the natural history of high-risk HPV types, resulting in reduced HPV-16/18 infections while HPV-52 infections persist with decreased clearance and increased progression. The study shows that vaccinated populations have distinct HPV epidemiological profiles, indicating that current cervical cancer screening algorithms may be suboptimal.
- Qi Chen
- Jiali Quan
- Ningshao Xia
