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Showing 1–3 of 3 results

Advanced filters: Author: Lindsie Martin Clear advanced filters

Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation

CRISPR-Cas12a catalyses RNA-guided DNA cleavage. Here, authors present structure-function studies of a high-fidelity Cas12a variant that reveal how helical transition of a conserved “bridge helix” facilitates R-loop propagation and DNA cleavage.

Chhandosee Ganguly
Swarmistha Devi Aribam
Rakhi Rajan
ResearchOpen Access28 Jan 2026
Nature Communications

P: 1-17
Systematic data capture reduces the need for source data verification: exploratory analysis from a phase 2 multicenter randomized controlled platform trial

Abbasi et al. evaluate the value of source data verification, a costly but traditional element of clinical trials. They find it is largely redundant when used with a systematic strategy to promote efficient and accurate data capture, monitoring, and safety in a phase II platform trial.
Trial Registration: https://clinicaltrials.gov/study/NCT04488081

Ali B. Abbasi
Kathleen D. Liu
Alejandro Botello Barragan
ResearchOpen Access29 Oct 2025
Communications Medicine

Volume: 5, P: 1-10
Clinical trial design during and beyond the pandemic: the I-SPY COVID trial

Carolyn S. Calfee
Kathleen D. Liu
Lindsie L. Boerger
Correspondence20 Jan 2022
Nature Medicine

Volume: 28, P: 9-11

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