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This work develops a reconfigurable heterojunction with coupled charge tunneling and ferroelectric polarization, enabling the integration of memory, sensing, and logic computation within a single device.

Structures of the Arabidopsis thaliana auxin exporter PIN1 in the apo state, bound to the natural auxin or bound to an inhibitor provide insights into the polar auxin transport mechanisms mediated by PIN family transporters.

Gallium is used as a sacrificial agent and mixing medium for the isothermal solidification synthesis of high-entropy alloy nanomaterials with diverse crystallinities and morphologies.

Precise control of the growth of transition metal dichalcogenides layers in atomically thin van der Waals heterostructures has gained significant attention. Here, the authors report 100% overlapped vertical ReS₂/WS₂heterostructures by utilizing the twinned growth behaviour of two-dimensional materials.

The mechanisms and kinetics behind the anti-sintering behavior of supported metal nanoparticles under ultrafast heating remain unclear. Here, in situ scanning transmission electron microscopy and theoretical analysis reveal an ultrafast-heating–induced metastable state that suppresses thermal sintering while enhancing crystallinity of the metal nanoparticles and their interfaces.

Lai and Xu et al. used cryo-electron microscopy and functional analyses to elucidate the glucose-6-phosphate uniport mechanism of human solute carrier family 37 member 2 and its structural dynamics, offering insights into glucose metabolism and related disorders.

The three-dimensional structure of intact human γ-secretase complex at 4.5 Å resolution is revealed by cryo-electron-microscopy single-particle analysis; the complex comprises a horseshoe-shaped transmembrane domain containing 19 transmembrane segments, and a large extracellular domain from nicastrin, which sits immediately above the hollow space formed by the horseshoe.

High-entropy materials are used in a range of applications but their synthesis at the nanoscale remains challenging. Now, a robust and general strategy to prepare high-entropy alloy and ceramic nanoparticles has been developed using laser scanning ablation. This approach takes only five nanoseconds per pulse to ablate precursors at atmospheric temperature and pressure.

The migration and hygroscopicity of lithium salt in doped spiro-OMeTAD hampers the device efficiency of perovskite solar cells. Here, the authors employ Eu(TFSI)₂ salts to generate superoxide radical for facile pre-oxidation, achieving enhanced efficiency and stability of solar cells and modules.

Designing materials with optimal properties is a longstanding challenge, as current methods struggle to explore the vast chemical space effectively. Here, the authors combine generative model with optimization methods to design novel and highly active alloy electrocatalysts for CO₂ electroreduction.

Using complementary cryo-electron microscopy and functional studies, the authors demonstrate that botulinum neurotoxins exploit the accompanying nontoxic bacterial proteins, OrfXs and P47, activated by host digestive proteases, to greatly enhance their oral toxicity.

This study reveals that ion displacement–induced antiferroelectricity in CuBiP₂Se₆ enables polymorphic functionalization, allowing a single device to achieve multilevel conductance and synaptic behavior for energy-efficient neuromorphic computing.

MoS₂ nanostructures are potentially useful in electronic applications. Here, Fei et al. show using in situ electron microscopy that MoS₂grows in a vertical manner at low temperature, then rotates to horizontal structures, and finally develops in size by merging adjacent flakes at high temperature.

A study introduces a novel method to grow single-crystal Cu₂O thin films with selected crystal orientations, highlighting enhanced bulk carrier mobility and carrier diffusion length along the [111] direction that yields Cu₂O photocathodes with improved performance.

Continuous Na consumption and dendrite have hampered the development of Na metal batteries. Here, authors designed fluorine-doped micropore-covered mesoporous carbon fibers as current collectors for anode-free Na metal batteries with improved cycle life.

Ammonium ion batteries are of growing interest for energy storage research. Here, the authors observe two-step pseudocapacitive storage behavior in an ammonium acetate electrolyte, resulting in a superior ammonium ion storage capacity.

The Curie temperature of Fe_5+xGeTe₂ thin films can be modulated from 260 to 380 K via iron doping, allowing the two-dimensional material to be used to create planar spiral inductors and low-pass Butterworth filters.

The in-situ visualization of the evolution of metal nanodroplets at multiphase interfaces remains a challenge. Here, the authors directly observe the motion and jetting behaviors of Hg nanodroplets regulated at solid-gas and solid-liquid interfaces.

In plants, hyperosmolality stimuli triggers opening of the osmosensitive channels, leading to a rapid downstream signaling cascade. Here, the authors solve the cryo-EM structure of an osmosensitive channel from Arabidopsis OSCA1.2 in its inactivated state.

Cryo-EM, X-ray crystallography and mutational analyses reveal how Dengue and Zika virus protein NS5 suppresses STAT2 activity and interferon response in host cells.

Lithium sulfur batteries are promising for advanced energy storage, but polysulfide shuttling limits performance lifetime. Here the authors report selenium-doping in a sulfur-based cathode to prevent dissolution of polysulfide intermediates, leading to ether compatibility, high capacity and stable cycling.

The atomic structure of human γ-secretase at 3.4 Å resolution, determined by single-particle cryo-electron microscopy.

Metal-organic frameworks (MOFs) are typically synthesized in equilibrium liquid-phase reactions. Here, the authors have developed and present a general non-equilibrium flame aerosol method to produce nanocrystal, amorphous, and bi-metallic MOFs.

The growth of crystals as spirals is unusual and this morphology can be applied to the development of flexible sensors and soft robots when the crystals respond to external stimuli. Here, the authors report the incorporation of a non-uniform layer of a polymer blend onto slender centimeter-size organic crystals to produce crystals having spiral shapes that respond reversibly to environmental variations.

Subcentimetre-size black phosphorous and its alloy films have been achieved on conventional substrates through sustained feedstock release design, and exhibit high crystalline quality and composition-dependent bandgap tunability.

Cryo-EM structures are determined for the abscisic acid (ABA) exporter ABCG25 in Arabidopsis in the apo, ABA-bound and ATP-bound states, which facilitate our understanding of the ABA transport and signalling processes in plants.

Kuang, Dou et al. show that upon Salmonella Typhimurium infection in mice, macrophages release extracellular vesicles (EVs) that harbor iron-uptake receptors. By sequestering iron via a humoral mechanism, these EVs limit bacterial growth and thereby protect against infection.

AXL is overexpressed and has been investigated as a therapeutic target in several cancer types, including lung cancer. Here the authors design AXLdirected CAR-T cells and show that their anti-tumor activity can be improved in combination with microwave ablation in preclinical lung cancer models.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

The anion channel SLAC1 controls stomatal closure upon phosphoactivation. Here via structural analysis and electrophysiology, the authors propose an inhibition-release model where phosphorylation causes dissociation of a cytosolic plug from the SLAC1 transmembrane domains to induce conformational change in the pore-forming helices.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Designing efficient selector devices remains a challenge. Here, the authors propose a CuAg alloy-based selector with excellent ON/OFF ratio and thermal stability. It can effectively suppress the sneak-path current in 1S1R arrays, making it suitable for storage class memory and neuromorphic computing applications.

Organic crystals represent potential alternatives to silicon dioxide due to their high flexibility and controllable properties. Here, the authors prepared a hybrid organic crystal material that responds mechanically to infrared light.

The commercialization of solar cells based on hybrid perovskites requires challenges of device stability and scalable production to be addressed. Ronget al. report ambient-processed printable mesoscopic perovskite solar cells with a lifetime of over 130 days in ambient air with 30% relative humidity.

Geckos are small, agile reptiles with nocturnal habits. Here, the authors sequence the genome of the Schlegel’s Japanese Gecko and reveal gene family expansions and reductions associated with formation of adhesive setae, nocturnal vision, tail regeneration, and diversification of olfactory sensation.

A form of superconductivity where strong spin–orbit coupling combines with topological band inversions to produce strong robustness against magnetic fields is shown in a few-layer transition metal dichalcogenide.

The use of electrochemical energy storage systems based on alkali metal electrodes is hindered by the dendrites’ growth and volume changes upon cycling. Here, the authors propose nitrogen and zinc co-doped porous carbon nanofibers as potassium metal hosting material for reversible metal deposition.

Whether the quantum Griffiths singularity state exists in one-dimensional (1D) systems remains elusive. Here, Zhang et al. report violation of the Pauli limit in the superconducting critical field and multiple phase transitions in the current-voltage hysteresis loops in a Ta₂PdS₅ nanowire, suggesting signatures of quasi-1D quantum Griffith singularity.

Flexoelectricity is the ability of materials to generate electricity upon bending. Here it is demonstrated that adding light to mechanical oscillation enhances effective flexoelectric coefficients by orders of magnitude, with the halide perovskites showing the largest coefficients.

Ma et al. report Pb-Sn alloyed perovskite with vertical gradient bandgap for bias-switchable photodetectors with response from visible to NIR region, enabling day-night imaging without Infrared Cutfilter Removal for color perception under infrared interference and 26 bit gray-level resolution.

The generation of hydrogen fuel from water and visible light requires photoelectrodes that are inexpensive, stable and highly active. Now, Luo, Grätzel and co-workers report Cu₂O photocathodes that reach these goals. Incorporation into an unassisted solar water splitting device gives ~3% solar-to-hydrogen conversion efficiency.

Here, the authors determine seroprevalence of antibodies to SARS-CoV-2 in healthy blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China between January and April 2020. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18–60 year-old adults is, with 2.66%, the highest in Wuhan.

X-ray detectors based on dual-site-doped perovskite single crystals exhibit excellent sensitivity of 2.6 × 10⁴ μC Gy_air⁻¹ cm^–2 under a low field of 1 V cm^–1. The detectable dose rate is as low as 7.09 nGy_air s^–1. The operational stability is beyond half a year.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Comparative genomics can provide valuable insights on adaptations to hostile environments. Here, the authors sequence the genomes and transcriptomes of the Bactrian camel, dromedary and alpaca, to reveal the demographic history of the group as well as metabolic adaptations to the desert environment.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.