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IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression

IGF2BP3 recruits NUDT21 to the m6A-modified site of SPTBN1, promoting alternative polyadenylation and generating oncogenic short transcripts in ovarian cancer. The long isoform suppresses tumor growth by binding CDK1 and blocking the G2/M phase.

Xin Luo
Lingcui Xie
Jing Xu
ResearchOpen Access29 Apr 2025
Communications Biology

Volume: 8, P: 1-13
CSTF3 contributes to platinum resistance in ovarian cancer through alternative polyadenylation of lncRNA NEAT1 and generating the short isoform NEAT1_1

Xin Luo
Qinglv Wei
Jing Xu
ResearchOpen Access19 Jun 2024
Cell Death & Disease

Volume: 15, P: 1-15

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IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression

CSTF3 contributes to platinum resistance in ovarian cancer through alternative polyadenylation of lncRNA NEAT1 and generating the short isoform NEAT1_1

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