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Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis

Lipoprotein uptake dependent on sulfated glycosaminoglycans linked to cell-surface proteoglycans is a key determinant of ferroptosis sensitivity in cancer.

Dylan Calhoon
Lingjie Sang
Javier Garcia-Bermudez
Research11 Jun 2025
Nature

Volume: 644, P: 799-808
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress

The localization of long non-coding RNAs plays a vital role in regulating cellular processes. In addition to compiling a database of organelle-associated lncRNAs, Sang et al. identify a role for the lncRNA GAS5 in regulating tricarboxylic acid cycle enzymes during nutrient stress.

Lingjie Sang
Huai-qiang Ju
Aifu Lin
Research04 Jan 2021
Nature Metabolism

Volume: 3, P: 90-106
Publisher Correction: Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Fangzhou Liu
Tian Tian
Aifu Lin
Amendments and Corrections06 Sept 2022
Nature Metabolism

Volume: 4, P: 1215
Protein kinase A modulation of Ca_V1.4 calcium channels

Phosphorylation of L-type calcium Ca_V channels by protein kinase A is essential for several physiological events. Here, the authors show how this kinase regulates Ca_V1.4 activity, suggesting a general regulatory mechanism for all L-type calcium channels.

Lingjie Sang
Ivy E. Dick
David T. Yue
ResearchOpen Access26 Jul 2016
Nature Communications

Volume: 7, P: 1-11
Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Chengyu Shi
Ying Wang
Aifu Lin
Amendments and CorrectionsOpen Access10 Dec 2024
Nature Communications

Volume: 15, P: 1-4
Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interaction promotes anti-tumour T cells responses

Chengyu Shi
Ying Wang
Aifu Lin
ResearchOpen Access14 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Alterations in cholesterol homeostasis may contribute to hepatic cancer aggressiveness. Liu, Tian, and Zhang et al. identify the long non-coding RNA SNHG6 as an important player in this process by linking cholesterol sensing with cancer cell growth through mTORC1 signaling.

Fangzhou Liu
Tian Tian
Aifu Lin
Research22 Aug 2022
Nature Metabolism

Volume: 4, P: 1022-1040
Comprehensive discovery and functional characterization of the noncanonical proteome

Chengyu Shi
Fangzhou Liu
Aifu Lin
ResearchOpen Access10 Jan 2025
Cell Research

Volume: 35, P: 186-204
Publisher Correction: Comprehensive discovery and functional characterization of the noncanonical proteome

Chengyu Shi
Fangzhou Liu
Aifu Lin
Amendments and CorrectionsOpen Access10 Mar 2025
Cell Research

Volume: 35, P: 229
Quantifying macromolecular interactions in living cells using FRET two-hybrid assays

This protocol describes a nondestructive FRET-based assay for measuring protein interactions in cultured cells. The correlation between FRET efficiencies and relative protein concentration can be used to determine relative binding affinities.

Elisabeth S Butz
Manu Ben-Johny
Christian Wahl-Schott
Protocols10 Nov 2016
Nature Protocols

Volume: 11, P: 2470-2498

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