Nature Search

Physical activity levels may impact on the risk of premature mortality in people with epilepsy

This study used accelerometer data from participants of the UK Biobank to reveal associations between sedentary and physical activity levels and mortality in people with epilepsy. These associations differ between people with epilepsy and the general population.

Lingjie Fan
Shengyi Liu
Jinmei Li
ResearchOpen Access07 Nov 2025
Nature Communications

Volume: 16, P: 1-14
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress

The localization of long non-coding RNAs plays a vital role in regulating cellular processes. In addition to compiling a database of organelle-associated lncRNAs, Sang et al. identify a role for the lncRNA GAS5 in regulating tricarboxylic acid cycle enzymes during nutrient stress.

Lingjie Sang
Huai-qiang Ju
Aifu Lin
Research04 Jan 2021
Nature Metabolism

Volume: 3, P: 90-106
Democratizing protein language model training, sharing and collaboration

SaprotHub is a community repository for protein language models.

Jin Su
Zhikai Li
Fajie Yuan
Research24 Oct 2025
Nature Biotechnology

P: 1-7
Publisher Correction: Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Fangzhou Liu
Tian Tian
Aifu Lin
Amendments and Corrections06 Sept 2022
Nature Metabolism

Volume: 4, P: 1215
Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interaction promotes anti-tumour T cells responses

Chengyu Shi
Ying Wang
Aifu Lin
ResearchOpen Access14 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Chengyu Shi
Ying Wang
Aifu Lin
Amendments and CorrectionsOpen Access10 Dec 2024
Nature Communications

Volume: 15, P: 1-4
Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma

Cohort-scale integration of clinical and proteomic data from tumor tissues in patients with pancreatic ductal adenocarcinoma led to the identification of a prognostic risk model for patient stratification as well as biomarkers of response to adjuvant chemotherapy, validated in independent external cohorts.

Lingxi Jiang
Jiejie Qin
Baiyong Shen
Research29 Jan 2024
Nature Medicine

Volume: 30, P: 749-761
A meta-analysis of 1,119 manipulative experiments on terrestrial carbon-cycling responses to global change

A synthesis of global change experiments that manipulated temperature, precipitation, carbon dioxide or nitrogen identifies a need to consider site-specific factors and interactions in Earth system models.

Jian Song
Shiqiang Wan
Mengmei Zheng
Research19 Aug 2019
Nature Ecology & Evolution

Volume: 3, P: 1309-1320
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Alterations in cholesterol homeostasis may contribute to hepatic cancer aggressiveness. Liu, Tian, and Zhang et al. identify the long non-coding RNA SNHG6 as an important player in this process by linking cholesterol sensing with cancer cell growth through mTORC1 signaling.

Fangzhou Liu
Tian Tian
Aifu Lin
Research22 Aug 2022
Nature Metabolism

Volume: 4, P: 1022-1040
Random-access wide-field mesoscopy for centimetre-scale imaging of biodynamics with subcellular resolution

Random-access wide-field mesoscopy enables the imaging of in vivo biodynamics in mice over an area of 160 mm² and at a subcellular spatial resolution of about 2 μm.

Ruheng Shi
Xinyue Chen
Lingjie Kong
ResearchOpen Access17 Apr 2024
Nature Photonics

Volume: 18, P: 721-730
Growth and Thermo-driven Crystalline Phase Transition of Metastable Monolayer 1T′-WSe₂ Thin Film

Wang Chen
Xuedong Xie
Yi Zhang
ResearchOpen Access25 Feb 2019
Scientific Reports

Volume: 9, P: 1-6
Video-rate imaging of biological dynamics at centimetre scale and micrometre resolution

Video-rate imaging of the brains of awake mice with a field of view of 10 × 12 mm² and a spatial resolution of 1.2 µm is accomplished.

Jingtao Fan
Jinli Suo
Qionghai Dai
Research08 Jul 2019
Nature Photonics

Volume: 13, P: 809-816
Large-field-of-view imaging by multi-pupil adaptive optics

Adaptive optics can counteract optical aberrations within tissues, but the field of view is typically limited. Multi-pupil adaptive optics expands the area that can be imaged, and this is demonstrated by multiple applications in the mouse brain imaging.

Jung-Hoon Park
Lingjie Kong
Meng Cui
Research08 May 2017
Nature Methods

Volume: 14, P: 581-583
Comprehensive discovery and functional characterization of the noncanonical proteome

Chengyu Shi
Fangzhou Liu
Aifu Lin
ResearchOpen Access10 Jan 2025
Cell Research

Volume: 35, P: 186-204
Serum multi-trace elements and post-stroke cognitive impairment: a prospective observational cohort study

Ruolin Zhou
Weijie Zhai
Li Sun
ResearchOpen Access01 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-8
Identification and affinity enhancement of T-cell receptor targeting a KRAS^G12V cancer neoantigen

Neoantigens derived from somatic mutations in KRAS represent promising targets for cancer immunotherapy. Through structure-based design, the authors identify the KRAS-G12V specific affinity-enhanced TCR, offering great promise for advancing cancer immunotherapy.

Mengyu Zhang
Wei Xu
Sheng Ye
ResearchOpen Access29 Apr 2024
Communications Biology

Volume: 7, P: 1-13
An insight into the origin of elemental chromium in the lacquer of Qin terracotta warriors

Yang Chenchen
Rong Bo
Lu Wenxian
ResearchOpen Access08 Aug 2024
Heritage Science

Volume: 12, P: 1-14
A global database of plant production and carbon exchange from global change manipulative experiments

Jian Song
Jingyi Ru
Shiqiang Wan
ResearchOpen Access02 Oct 2020
Scientific Data

Volume: 7, P: 1-7
Integrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma

A miRNA multi-omics study reveals not only mechanisms for miRNA dysregulation, but also the tumor heterogeneity and immunological diversity within low grade glioma, and presents better prognostic value than traditional molecular markers.

Zhen Yang
Xiaocen Liu
Hui Yang
ResearchOpen Access06 Jul 2024
Communications Biology

Volume: 7, P: 1-20
Publisher Correction: Comprehensive discovery and functional characterization of the noncanonical proteome

Chengyu Shi
Fangzhou Liu
Aifu Lin
Amendments and CorrectionsOpen Access10 Mar 2025
Cell Research

Volume: 35, P: 229
Effects of HIV-1 genotype on baseline CD4+ cell count and mortality before and after antiretroviral therapy

Zhiqiang Cao
Jianjun Li
Yuhua Ruan
ResearchOpen Access28 Sept 2020
Scientific Reports

Volume: 10, P: 1-10

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