Activation of the mammalian target of rapamycin complex 1 in mature retinal ganglion cells promotes axonal regeneration in a mouse optic nerve crush model but the role of its downstream effectors is not clear. Here the authors show that S6K1 plays a dual role in axon regeneration, whereas 4E-BP inhibition is not sufficient but necessary for axon regeneration.
- Liu Yang
- Linqing Miao
- Yang Hu
