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Showing 1–14 of 14 results
Advanced filters: Author: Linus T. Tsai Clear advanced filters

  • Flores et al. show that brain-penetrant eIF2B agonists suppress ISR activation in cellular and mouse models of ALS and reduce ISR biomarkers in humans, enabling further clinical studies of ISR inhibition in individuals with neurological diseases

    • Brittany N. Flores
    • Seungyoon B. Yu
    • Joseph W. Lewcock
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • The blood-brain barrier (BBB) regulates the extracellular composition of the central nervous system (CNS), but it is not known whether its properties differ across CNS regions. Here, the authors show in mice that the BBB exhibits regional specializations, and that such specializations can be important for the function of specific neural circuits.

    • Marie Blanchette
    • Kaja Bajc
    • Richard Daneman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The dorsal pons in the brainstem is packed with clusters of neurons, including the parabrachial nucleus, that are involved in many vital functions. Here, authors use single nucleus RNA sequencing and MERFISH to create a spatially defined transcriptional atlas of this region.

    • Stefano Nardone
    • Roberto De Luca
    • Bradford B. Lowell
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • A single-cell atlas of white adipose tissue from mouse and human reveals diverse cell types and similarities and differences across species and dietary conditions.

    • Margo P. Emont
    • Christopher Jacobs
    • Evan D. Rosen
    Research
    Nature
    Volume: 603, P: 926-933

  • Whole-genome bisulphite sequencing data from diverse human cell and tissue types shows that only about 22% of CpGs change their methylation state across these cell types; most of these CpGs are located at gene regulatory elements, particularly enhancers and transcription-factor-binding sites, and these selected regions with dynamic DNA methylation patterns could help to define putative regulatory elements further.

    • Michael J. Ziller
    • Hongcang Gu
    • Alexander Meissner
    Research
    Nature
    Volume: 500, P: 477-481

  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330

  • Creatine can be used for thermogenesis in adipocytes. Here Kazak et al. show that creatine uptake is required to sustain this thermogenic pathway. Knockdown of the creatine transporter, CrT, in adipocytes decreases thermogenesis and energy expenditure, whereas creatine supplementation increases energy expenditure in mice fed a high-fat diet.

    • Lawrence Kazak
    • Janane F. Rahbani
    • Bruce M. Spiegelman
    Research
    Nature Metabolism
    Volume: 1, P: 360-370

  • The hypothalamic arcuate–median eminence (Arc-ME) complex is rich with functionally distinct cell types, a fraction of which have been characterized. The authors profile 20,921 individual cells by single-cell RNA-seq, identifying 50 Arc-ME cell types and their markers, determining each's response to energy status and implicating two neuron populations in the genetic control of obesity.

    • John N Campbell
    • Evan Z Macosko
    • Linus T Tsai
    Research
    Nature Neuroscience
    Volume: 20, P: 484-496