Nature Search

Triangular-ordered Co atoms activate substrates for ampere-level durable hydrogen production

Atomically dispersed catalysts show promising activity for electrochemical reactions but often suffer from limited stability. Here, the authors report an atom-ordering strategy that forms triangular Co sites to activate the substrate for durable alkaline hydrogen production.

Mingyu Ma
Boyi Zhao
Yongmin He
ResearchOpen Access03 Dec 2025
Nature Communications

Volume: 17, P: 1-12
The 2025 generation

Twelve early-career researchers who started their independent research groups in 2025 reflect on their experiences from this first year of the journey, describe the opportunities they have had and the challenges they have faced, and share their hopes and plans for the future.

Hana Aliee
Leire Bejarano-Bosque
Zefang Tang
Reviews10 Dec 2025
Nature Cancer

Volume: 6, P: 1930-1934
Author Correction: Engineering a precise adenine base editor with minimal bystander editing

Liang Chen
Shun Zhang
Dali Li
Amendments and Corrections22 Apr 2024
Nature Chemical Biology

Volume: 20, P: 1094
Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Liang Chen
Mengjia Hong
Dali Li
Amendments and Corrections24 Apr 2024
Nature Biotechnology

Volume: 42, P: 987
Engineering a photoactivatable A-to-I RNA base editor for gene therapy in vivo

A light-inducible RNA base editor fine-tunes gene expression for therapeutics.

Huiying Li
Yuhao Qiu
Dali Li
Research31 Mar 2025
Nature Biotechnology

P: 1-12
Amorphizing noble metal chalcogenide catalysts at the single-layer limit towards hydrogen production

The scarcity and high price of noble metal catalysts pose critical challenges for the chemical industry, and finding strategies that ensure complete atom efficiency has become a pivotal endeavour. This work introduces the fabrication of amorphous single-layer PtSe_x catalysts for the hydrogen evolution reaction with high atom-utilization efficiency.

Yongmin He
Liren Liu
Zheng Liu
Research10 Mar 2022
Nature Catalysis

Volume: 5, P: 212-221
Engineering APOBEC3A deaminase for highly accurate and efficient base editing

Through rational engineering of A3A deaminase, Yang and colleagues have designed CBEs termed haA3A-CBEs, which feature a condensed editing window and minimal off-target effects that are independent of defined sequence contexts and methylation status.

Lei Yang
Yanan Huo
Dali Li
Research29 Mar 2024
Nature Chemical Biology

Volume: 20, P: 1176-1187
β-Hydroxybutyrate promotes cancer metastasis through β-hydroxybutyrylation-dependent stabilization of Snail

Snail is involved in the regulation of epithelial-mesenchymal transition and metastasis. Here, the authors show that the metabolite β-hydroxybutyrate promotes pancreatic cancer metastasis through protecting Snail from degradation.

Wenna Jiang
Meng Wang
Jihui Hao
ResearchOpen Access17 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Liang Chen
Biyun Zhu
Dali Li
Amendments and Corrections24 Apr 2024
Nature Biotechnology

Volume: 42, P: 987
Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD

There is a low efficiency of A-to-G base conversion in at specific positions using base editors. Here the authors fuse ABE8e with the Rad51 DNA-binding domain to generate a hyperactive ABE allowing improved A-to-G editing efficiency at the region proximal to the PAM and improved simultaneous A/C conversion efficiency.

Niannian Xue
Xu Liu
Xiaohui Zhang
ResearchOpen Access03 Mar 2023
Nature Communications

Volume: 14, P: 1-12
Engineering a precise adenine base editor with minimal bystander editing

A precise adenine base editor variant, ABE9, was developed to generate single adenine transition at pathogenic homopolymeric adenine sites with minimal DNA/RNA off-target effects, suggesting promising potential for gene therapeutics.

Liang Chen
Shun Zhang
Dali Li
Research13 Oct 2022
Nature Chemical Biology

Volume: 19, P: 101-110
Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

A base editor for precise adenine transversions is demonstrated in mouse embryos.

Liang Chen
Mengjia Hong
Dali Li
Research15 Jun 2023
Nature Biotechnology

Volume: 42, P: 638-650
CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β⁰/β⁰ transfusion-dependent β-thalassemia

Preliminary results from a phase 1/2 trial with 18-month follow-up show that transplantation of CRISPR–Cas9 BCL11A-edited autologous hematopoietic cells in two children with β-thalassemia was safe and achieved transfusion independence.

Bin Fu
Jiaoyang Liao
Yuxuan Wu
Research04 Aug 2022
Nature Medicine

Volume: 28, P: 1573-1580
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Improved cytosine base editors are created by repurposing an adenine deaminase.

Liang Chen
Biyun Zhu
Dali Li
Research10 Nov 2022
Nature Biotechnology

Volume: 41, P: 663-672
Construction of multiphysics coupling equations and study on flow field migration patterns in shallow buried goaf under air leakage conditions

Jingtao Pan
Chen Qiu
Qiang Yuan
ResearchOpen Access11 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Synthesis and Properties Evolution of a Family of Tiara-like Phenylethanethiolated Palladium Nanoclusters

Jishi Chen
Liren Liu
Zhikun Wu
ResearchOpen Access16 Nov 2015
Scientific Reports

Volume: 5, P: 1-8
CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis

Ziyun Li
Jia Jiang
Jinzhong Zhao
ResearchOpen Access24 Feb 2025
Bone Research

Volume: 13, P: 1-16
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly aggressive Kras-independent pancreatic cancer cells to develop.

Giannicola Genovese
Alessandro Carugo
Lynda Chin
Research08 Feb 2017
Nature

Volume: 542, P: 362-366
Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain

Li and colleagues report base editor variants with improved targeting efficiencies and broader editing windows by fusing the original base editors with the single-stranded DNA-binding domain of Rad51.

Xiaohui Zhang
Liang Chen
Dali Li
Research11 May 2020
Nature Cell Biology

Volume: 22, P: 740-750
Whole-genome sequence-based analysis of thyroid function

Levels of circulating thyrotropin and free thyroxine reflect thyroid function, however, their genetic underpinnings remain poorly understood. Taylor et al. take advantage of whole-genome sequence data from cohorts within the UK10K project to identify novel variants associated with these traits.

Peter N. Taylor
Eleonora Porcu
Pingbo Zhang
ResearchOpen Access06 Mar 2015
Nature Communications

Volume: 6, P: 1-11
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Imputation uses genotype information from SNP arrays to infer the genotypes of missing markers. Here, the authors show that an imputation reference panel derived from whole-genome sequencing of 3,781 samples from the UK10K project improves the imputation accuracy and coverage of low frequency variants compared to existing methods.

Jie Huang
Bryan Howie
Nicole Soranzo
ResearchOpen Access14 Sept 2015
Nature Communications

Volume: 6, P: 1-9
A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

Population-based genome sequencing provides an increasingly rich resource for the identification of low-frequency, large effect variants associated with clinically important phenotypes. Timpson et al. use UK10K data to identify a variant of the APOC3gene strongly associated with plasma triglyceride levels.

Nicholas J. Timpson
Klaudia Walter
Hou-Feng Zheng
ResearchOpen Access16 Sept 2014
Nature Communications

Volume: 5, P: 1-11
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system

Dali Li
Zhongwei Qiu
Mingyao Liu
Correspondence08 Aug 2013
Nature Biotechnology

Volume: 31, P: 681-683
Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Base editors that modify both adenine and cytosine broaden the potential applications of base editing.

Xiaohui Zhang
Biyun Zhu
Dali Li
Research01 Jun 2020
Nature Biotechnology

Volume: 38, P: 856-860
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.

Simon Haworth
Chin Yang Shapland
Beate St Pourcain
ResearchOpen Access21 Jan 2019
Nature Communications

Volume: 10, P: 1-16
The UK10K project identifies rare variants in health and disease

Low read depth sequencing of whole genomes and high read depth exomes of nearly 10,000 extensively phenotyped individuals are combined to help characterize novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with lipid-related traits; in addition to describing population structure and providing functional annotation of rare and low-frequency variants the authors use the data to estimate the benefits of sequencing for association studies.

Klaudia Walter
Josine L. Min
Weihua Zhang
ResearchOpen Access14 Sept 2015
Nature

Volume: 526, P: 82-90
Proton pump inhibitors may increase the risk of cisplatin-induced acute kidney injury in patients with nasopharyngeal carcinoma: a prospective cohort study

Haiqing Luo
Guihua Yi
Huafeng Liu
ResearchOpen Access13 Aug 2024
Scientific Reports

Volume: 14, P: 1-10
Comparison of the content of active ingredients and antioxidant, antibacterial and anti-inflammatory activities in different parts of Fructus Choerospondiatis

Yuchao Zhao
Chunfeng Xia
Liren He
ResearchOpen Access19 Nov 2024
Scientific Reports

Volume: 14, P: 1-17
Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos

Liren Wang
Yanjiao Shao
Dali Li
ResearchOpen Access01 Dec 2015
Scientific Reports

Volume: 5, P: 1-11
CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos

Genetic techniques in rats are developing apace. Here, Shao et al. describe how to use CRISPR/Cas-mediated genome editing to modify one-cell rat embryos and generate stable rat lines.

Yanjiao Shao
Yuting Guan
Dali Li
Protocols25 Sept 2014
Nature Protocols

Volume: 9, P: 2493-2512
The corrosion behavior of EW75 magnesium alloy in the research vessel KEXUE during the ocean voyage

Quantong Jiang
Dongzhu Lu
Baorong Hou
ResearchOpen Access12 Apr 2022
npj Materials Degradation

Volume: 6, P: 1-12
Feedback activation of EGFR/wild-type RAS signaling axis limits KRAS^G12D inhibitor efficacy in KRAS^G12D-mutated colorectal cancer

Juanjuan Feng
Zhongwei Hu
Xiufeng Pang
ResearchOpen Access05 Apr 2023
Oncogene

Volume: 42, P: 1620-1633
VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration

Fangfang Qi
Zejie Zuo
Kaihua Guo
ResearchOpen Access06 Jun 2023
Molecular Psychiatry

Volume: 28, P: 4374-4389
Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies

Liren Wang
Linxi Li
Dali Li
Correspondence07 Jan 2020
Cell Research

Volume: 30, P: 276-278
Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

Audrey E. Hendricks
Elena G. Bochukova
Hou-Feng Zheng
ResearchOpen Access29 Jun 2017
Scientific Reports

Volume: 7, P: 1-14
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

Liren Liu
Yan Yin
Pengbo Zhou
Research27 Mar 2012
Cell Research

Volume: 22, P: 1258-1269

Search

Triangular-ordered Co atoms activate substrates for ampere-level durable hydrogen production

The 2025 generation

Author Correction: Engineering a precise adenine base editor with minimal bystander editing

Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Engineering a photoactivatable A-to-I RNA base editor for gene therapy in vivo

Amorphizing noble metal chalcogenide catalysts at the single-layer limit towards hydrogen production

Engineering APOBEC3A deaminase for highly accurate and efficient base editing

β-Hydroxybutyrate promotes cancer metastasis through β-hydroxybutyrylation-dependent stabilization of Snail

Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD

Engineering a precise adenine base editor with minimal bystander editing

Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β⁰/β⁰ transfusion-dependent β-thalassemia

Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Construction of multiphysics coupling equations and study on flow field migration patterns in shallow buried goaf under air leakage conditions

Synthesis and Properties Evolution of a Family of Tiara-like Phenylethanethiolated Palladium Nanoclusters

CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain

Whole-genome sequence-based analysis of thyroid function

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

Heritable gene targeting in the mouse and rat using a CRISPR-Cas system

Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

The UK10K project identifies rare variants in health and disease

Proton pump inhibitors may increase the risk of cisplatin-induced acute kidney injury in patients with nasopharyngeal carcinoma: a prospective cohort study

Comparison of the content of active ingredients and antioxidant, antibacterial and anti-inflammatory activities in different parts of Fructus Choerospondiatis

Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos

CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos

The corrosion behavior of EW75 magnesium alloy in the research vessel KEXUE during the ocean voyage

Feedback activation of EGFR/wild-type RAS signaling axis limits KRAS^G12D inhibitor efficacy in KRAS^G12D-mutated colorectal cancer

VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration

Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

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