Nature Search

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

Gregory R. Dressler
J. Erby Wilkinson
Heiner Westphal
Research01 Mar 1993
Nature

Volume: 362, P: 65-67
In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation

De la Rosa et al. developed an in vivo CRISPR screening system to dissect macrophage regulation in multiple sclerosis models, revealing key cytokine signaling pathways that control myeloid cell behavior in neuroinflammation.

Clara de la Rosa
Arek Kendirli
Martin Kerschensteiner
ResearchOpen Access04 Dec 2025
Nature Neuroscience

P: 1-17
The three-dimensional structure of an intact monoclonal antibody for canine lymphoma

Lisa J. Harris
Steven B. Larson
Alexander McPherson
Research26 Nov 1992
Nature

Volume: 360, P: 369-372
Modeling human adaptive immune responses with tonsil organoids

An in vitro human tonsil tissue-based system captures key features of a functional germinal center and can be used to study humoral immune responses to vaccines, new antigens and adjuvants.

Lisa E. Wagar
Ameen Salahudeen
Mark M. Davis
Research11 Jan 2021
Nature Medicine

Volume: 27, P: 125-135
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Colombian biodiversity is governed by a rich and diverse policy mix

A qualitative and quantitative analysis of 186 biodiversity-related policies in Colombia is used to describe how biodiversity has been integrated into policy domains, which policy instruments are most prevalent and how the policy mix has changed over six decades.

Alejandra Echeverri
Paul R. Furumo
Eric F. Lambin
Research06 Feb 2023
Nature Ecology & Evolution

Volume: 7, P: 382-392
Ly6D⁺Siglec-H⁺ precursors contribute to conventional dendritic cells via a Zbtb46⁺Ly6D⁺ intermediary stage

The ontogeny of conventional and plasmacytoid dendritic cells (DC) and how these two cell types are related is not fully known. Here the authors identify a pool of bone marrow precursor cells expressing Ly6D Siglec-H and Zbtb46 that can differentiate into either cDC or pDC and show that type I IFN can limit cDC and favor pDC output from these precursors.

Konstantin Lutz
Andrea Musumeci
Anne B. Krug
ResearchOpen Access16 Jun 2022
Nature Communications

Volume: 13, P: 1-15
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model

Multiple sclerosis (MS) lesions are initiated by the infiltration of T cells to the CNS. Here, Kendirli et al. use a genome-wide CRISPR screen in an MS model to define the molecules that regulate T cell entry to the CNS.

Arek Kendirli
Clara de la Rosa
Naoto Kawakami
ResearchOpen Access14 Sept 2023
Nature Neuroscience

Volume: 26, P: 1713-1725
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

Blum et al. performed single-nucleus RNA sequencing of the adult mouse spinal cord. This analysis revealed heterogeneity in the autonomic and skeletal motor systems and provides a resource to study motor neurons in health and disease.

Jacob A. Blum
Sandy Klemm
Aaron D. Gitler
Research15 Feb 2021
Nature Neuroscience

Volume: 24, P: 572-583
Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity

Alonso and colleagues develop immune-stimulating antibody conjugates capable of specific delivery of TLR7/8 agonists to tumors, which induces durable antitumor immunity.

Shelley E. Ackerman
Cecelia I. Pearson
Michael N. Alonso
Research07 Dec 2020
Nature Cancer

Volume: 2, P: 18-33
Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
ResearchOpen Access03 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression

RNA sequencing of MEK inhibitor (selumetinib)-treated tumors reveals an upregulation of the JAK/STAT3 pathway, with combinatorial therapeutic strategies of JAK/STAT3 inhibitors and selumetinib investigated for the SHH subgroup of medulloblastoma.

Jamie Zagozewski
Stephanie Borlase
Tamra E. Werbowetski-Ogilvie
ResearchOpen Access14 Jul 2022
Communications Biology

Volume: 5, P: 1-17
Structural reorganization of the fungal endoplasmic reticulum upon induction of mycotoxin biosynthesis

Marike Johanne Boenisch
Karen Lisa Broz
Harold Corby Kistler
ResearchOpen Access13 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
Amendments and CorrectionsOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1

Search

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation

The three-dimensional structure of an intact monoclonal antibody for canine lymphoma

Modeling human adaptive immune responses with tonsil organoids

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Colombian biodiversity is governed by a rich and diverse policy mix

Ly6D⁺Siglec-H⁺ precursors contribute to conventional dendritic cells via a Zbtb46⁺Ly6D⁺ intermediary stage

A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity

Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression

Structural reorganization of the fungal endoplasmic reticulum upon induction of mycotoxin biosynthesis

Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

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