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Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

Little is known about the role of glycolysis in cellular senescence. Here, authors report that glycolysis-derived serine biosynthesis activates PKM2 to phosphorylate histone H3T11, prevent cell senescence, and promote healthy aging.

Yinsheng Wu
Lixu Tang
Xilan Yu
ResearchOpen Access10 Mar 2023
Nature Communications

Volume: 14, P: 1-21
Application of deep learning algorithms for identifying deterioration in the ushnisha (Head Bun) of the Leshan Giant Buddha

Chaokai Zhang
Ningbo Peng
Ye Zhu
ResearchOpen Access12 Nov 2024
Heritage Science

Volume: 12, P: 1-17
Cultural transmission ability of urban heritage along the Jiangsu section of the Beijing–Hangzhou Grand Canal

Ningbo Peng
Yinjia Chen
Ye Zhu
ResearchOpen Access15 Aug 2025
npj Heritage Science

Volume: 13, P: 1-14
Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction

Lei Qiao
Xinyi Zhang
Chunlan Xu
ResearchOpen Access23 Jun 2022
npj Science of Food

Volume: 6, P: 1-17
AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

Shuai Wang
Zongyang Qiu
Xu Li
ResearchOpen Access08 Jan 2021
Cell Research

Volume: 31, P: 126-140