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Showing 1–10 of 10 results
Advanced filters: Author: Loïc Carrique Clear advanced filters

  • Mechanisms ensuring the maintenance of the nuclear envelope -- a structure with roles in mechanical integrity, chromatin organization, and nucleocytoplasmic transport -- are not fully understood. Here, the authors show that dynamins preserve nuclear envelope homeostasis via their GTPase activity and microtubule interactions.

    • Célia Aveleira
    • Thibaud Martial
    • Ira Milosevic
    ResearchOpen Access
    Nature Communications
    P: 1-18

  • Borna disease virus 1 replicates and transcribes its negative sense RNA genome in the nucleus of infected cells. Here, the authors present the cryoEM structures of the large polymerase protein in complex with the tetrameric phosphoprotein, revealing the structural features that govern its activity.

    • Loïc Carrique
    • Franziska Günl
    • Jeremy R. Keown
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Influenza viruses carry their own RNAdependent RNA-polymerase that is highly conserved and a promising anti-viral target. Combining functional and structural data, Keown et al. characterise the inhibitory effect of nanobodies on 1918 pandemic H1N1 influenza strain polymerase complex and identify sensitive sites interfering with polymerase activity in vitro.

    • Jeremy R. Keown
    • Zihan Zhu
    • Jonathan M. Grimes
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Structural and biochemical studies of influenza virus RNA polymerase in complex with host acidic nuclear phosphoprotein 32 (ANP32) show how ANP32-mediated polymerase dimerization enables the replication of influenza viral RNA in a host-dependent manner.

    • Loïc Carrique
    • Haitian Fan
    • Jonathan M. Grimes
    Research
    Nature
    Volume: 587, P: 638-643

  • Plasmodium falciparum IMP-specific 5′-nucleotidase 1 (PfISN1) is of interest as a potential malaria drug target. Here, the authors report that IMP is a substrate, and ATP an allosteric activator, of PfISN1 and present PfISN1 crystal structures in the ligand-free state and bound to either IMP or ATP.

    • Loïc Carrique
    • Lionel Ballut
    • Nushin Aghajari
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Heterotrimers of collagen I (two α1 chains, one α2 chain) are crucial for the normal function of multiple tissues and organs. Here the authors show the molecular basis of both homotrimerization (three α1 chains) and heterotrimerization of collagen I through specific intermolecular interactions.

    • Urvashi Sharma
    • Loïc Carrique
    • David J. S. Hulmes
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10