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Showing 1–16 of 16 results
Advanced filters: Author: Luc Reymond Clear advanced filters

  • CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species.

    • Cédric Pourroy
    • Georgios N. Hatzopoulos
    • Pierre Gönczy
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-11

  • Existing DNA stains for live cell microscopy are either toxic, require illumination with blue light, or are not compatible with super-resolution microscopy. Here the authors develop SiRHoechst, a non-toxic far-red DNA stain that is compatible with super-resolution microscopy.

    • Gražvydas Lukinavičius
    • Claudia Blaukopf
    • Kai Johnsson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • The discovery and characterization of small-molecule antagonists that inhibit the stimulator of interferon genes (STING) protein may help to develop therapies for the treatment of autoinflammatory disease.

    • Simone M. Haag
    • Muhammet F. Gulen
    • Andrea Ablasser
    Research
    Nature
    Volume: 559, P: 269-273

  • Activatable fluorophores are of interest for a wide range of applications but the need for caging groups complicates their development and application. Here, the authors report on a photoactivatable silicon rhodamine derivative and its application in live cell imaging and single-particle tracking.

    • Michelle S. Frei
    • Philipp Hoess
    • Kai Johnsson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • The combination of synthetic ligands, luminescent proteins and binding proteins converts a well-established ligand-sensing system into a tunable and quantitative reporter for drug concentrations in blood, as demonstrated with six different drugs and using a simple digital camera.

    • Rudolf Griss
    • Alberto Schena
    • Kai Johnsson
    Research
    Nature Chemical Biology
    Volume: 10, P: 598-603

  • The array of tools to image peroxisome regulation is still limited. Here, the authors develop improved fatty acid-based probes with high peroxisome specificity and bright fluorescence in the red/far-red spectrum, which makes them ideal to study peroxisomes in live cells and whole organisms.

    • Daria Korotkova
    • Anya Borisyuk
    • Triana Amen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Cathepsins are relevant therapeutic targets in cancer and other diseases. Here, the authors developed a different approach to block the activity of cathepsins in specific cellular contexts by combining non-natural peptide inhibitors with antibodies, enhancing therapeutic efficacy while reducing side effects.

    • Aaron Petruzzella
    • Marine Bruand
    • Elisa Oricchio
    Research
    Nature Chemical Biology
    Volume: 20, P: 1188-1198

  • A computational deep learning approach is used to design synthetic proteins that target the neosurfaces formed by protein–ligand interactions, with applications in the development of new therapeutic modalities such as molecular glues or cell-based therapies.

    • Anthony Marchand
    • Stephen Buckley
    • Bruno E. Correia
    ResearchOpen Access
    Nature
    Volume: 639, P: 522-531

  • Microtubules carry patterns of post-translational modifications that are important for the regulation of key cellular processes. Now a semi-synthetic method facilitates the production of tubulins with defined post-translational modifications. Using these designer tubulins, polyglutamylation of α-tubulin is found to promote its detyrosination by enhancing the activity of the carboxypeptidase vasohibin/small vasohibin-binding protein.

    • Eduard Ebberink
    • Simon Fernandes
    • Charlotte Aumeier
    Research
    Nature Chemistry
    Volume: 15, P: 1179-1187

  • Snap-tag reporter mice allow flexible yet efficient targeting of chemical indicators to genetically labeled cells in vivo. With this strategy, cells can either be labeled fluorescently or ablated using the same reporter.

    • Guoying Yang
    • Fernanda de Castro Reis
    • Paul A Heppenstall
    Research
    Nature Methods
    Volume: 12, P: 137-139

  • There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB+ sensory neurons in the mouse skin attenuates this hypersensitivity.

    • Rahul Dhandapani
    • Cynthia Mary Arokiaraj
    • Paul A. Heppenstall
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Fluorescent probes for bioimaging need to exhibit bright fluorescence, be biocompatible and offer several alternatives for attachment to biomolecules of interest. Here, a near-infrared silicon–rhodamine fluorophore is introduced that can be coupled to intracellular proteins in live cells and tissues and can be exploited for super-resolution microscopy.

    • Gražvydas Lukinavičius
    • Keitaro Umezawa
    • Kai Johnsson
    Research
    Nature Chemistry
    Volume: 5, P: 132-139

  • Far-red fluorogenic probes for live-cell imaging of either actin or tubulin are described and used for super-resolution microscopy of various structures in a variety of cell types.

    • Gražvydas Lukinavičius
    • Luc Reymond
    • Kai Johnsson
    Research
    Nature Methods
    Volume: 11, P: 731-733