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Showing 1–50 of 51 results

Advanced filters: Author: Luca Pagani Clear advanced filters

West Asian sources of the Eurasian component in Ethiopians: a reassessment

Ludovica Molinaro
Francesco Montinaro
Luca Pagani
ResearchOpen Access11 Dec 2019
Scientific Reports

Volume: 9, P: 1-8
Genomic analyses inform on migration events during the peopling of Eurasia

Whole-genome sequencing of individuals from 125 populations provides insight into patterns of genetic diversity, natural selection and human demographic history during the peopling of Eurasia and finds evidence for genetic vestiges of an early expansion of modern humans out of Africa in Papuans.

Luca Pagani
Daniel John Lawson
Mait Metspalu
Research21 Sept 2016
Nature

Volume: 538, P: 238-242
Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

Polygenic scores are believed to hold future promise for trait prediction and personalized medicine, but are sensitive to demographic history. Here, Marnetto et al. develop partial polygenic scores supplemented with local ancestry deconvolution which improves prediction accuracy into recently admixed European populations.

Davide Marnetto
Katri Pärna
Luca Pagani
ResearchOpen Access02 Apr 2020
Nature Communications

Volume: 11, P: 1-9
Very large electro-optic responses in H-bonded heteroaromatic films grown by physical vapour deposition

Antonio Facchetti
Elisabetta Annoni
Giorgio A. Pagani
Research28 Nov 2004
Nature Materials

Volume: 3, P: 910-917
Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia

Luca Valenti
Elena Corradini
Heinz Zoller
Amendments and Corrections14 Dec 2023
Nature Reviews Endocrinology

Volume: 20, P: 185
Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Combined analysis of new genomic data from 116 ancient hunter-gatherer individuals together with previously published data provides insights into the genetic structure and demographic shifts of west Eurasian forager populations over a period of 30,000 years.

Cosimo Posth
He Yu
Johannes Krause
ResearchOpen Access01 Mar 2023
Nature

Volume: 615, P: 117-126
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
The Persian plateau served as hub for Homo sapiens after the main out of Africa dispersal

The timing and chronology of the movement of Homo sapiens after migration out of Africa remains unclear. Here, the authors combine a genetic approach with a palaeoecological model to estimate that the Persian Plateau could have been a hub for migration out of Africa, suggesting the environment may have been suitable for population maintenance.

Leonardo Vallini
Carlo Zampieri
Luca Pagani
ResearchOpen Access25 Mar 2024
Nature Communications

Volume: 15, P: 1-13
Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Rosanna Asselta
Elvezia Maria Paraboschi
Cecilia Garlanda
Research27 May 2022
Nature Immunology

Volume: 23, P: 865-867
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.

Giulia Della Chiara
Federica Gervasoni
Massimiliano Pagani
ResearchOpen Access20 Apr 2021
Nature Communications

Volume: 12, P: 1-18
Correction: Corrigendum: Geographic population structure analysis of worldwide human populations infers their biogeographical origins

Eran Elhaik
Tatiana Tatarinova
R. Spencer Wells
Amendments and CorrectionsOpen Access31 Oct 2016
Nature Communications

Volume: 7, P: 1
The African Genome Variation Project shapes medical genetics in Africa

The African Genome Variation Project contains the whole-genome sequences of 320 individuals and dense genotypes on 1,481 individuals from sub-Saharan Africa; it enables the design and interpretation of genomic studies, with implications for finding disease loci and clues to human origins.

Deepti Gurdasani
Tommy Carstensen
Manjinder S. Sandhu
ResearchOpen Access03 Dec 2014
Nature

Volume: 517, P: 327-332
Deformable registration and generative modelling of aortic anatomies by auto-decoders and neural ODEs

Riccardo Tenderini
Luca Pegolotti
Simone Deparis
ResearchOpen Access03 Dec 2025
npj Biological Physics and Mechanics

Volume: 2, P: 1-15
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Stravalaci et al. examined recognition of SARS-CoV-2 by human soluble innate pattern recognition receptor. They report that pentraxin 3 and mannose-binding protein recognize viral nucleoprotein and spike, respectively. Mannose-binding lectin has antiviral activity, and human genetic polymorphisms of MBL2 are associated with more severe COVID-19.

Matteo Stravalaci
Isabel Pagani
Cecilia Garlanda
Research31 Jan 2022
Nature Immunology

Volume: 23, P: 275-286
Therapeutic activity of modified U1 core spliceosomal particles

Modification of the spliceosome is being tested as a potential therapy for exon-skipping diseases, such as spinal muscular atrophy (SMA). Here the authors show that 70K and stem loop IV structural elements of a modified U1 particle are essential for splicing enhancement and effective treatment of SMA mice.

Malgorzata Ewa Rogalska
Mojca Tajnik
Franco Pagani
ResearchOpen Access04 Apr 2016
Nature Communications

Volume: 7, P: 1-13
Consensus Statement on the definition and classification of metabolic hyperferritinaemia

This Consensus Statement discusses the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction. The authors propose an updated definition and a provisional staging system for metabolic hyperferritinaemia, highlight research gaps and provide suggestions for the design and outcome measures for future studies.

Luca Valenti
Elena Corradini
Heinz Zoller
Reviews17 Feb 2023
Nature Reviews Endocrinology

Volume: 19, P: 299-310
Human migration from the Levant and Arabia into Yemen since Last Glacial Maximum

Andreas Henschel
Riyadh Saif-Ali
Pierre Zalloua
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-12
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Author Correction: Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Cosimo Posth
He Yu
Johannes Krause
Amendments and CorrectionsOpen Access22 Mar 2023
Nature

Volume: 616, P: E5
Geographic population structure analysis of worldwide human populations infers their biogeographical origins

Current methods to identify the geographical origin of humans based on DNA data present limited accuracy. Here, the authors develop a new algorithm, the Genographic Population Structure (GPS), and demonstrate its ability to place worldwide individuals within their country or, in some cases, village of origin.

Eran Elhaik
Tatiana Tatarinova
Janet S. Ziegle
ResearchOpen Access29 Apr 2014
Nature Communications

Volume: 5, P: 1-13
Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into Neanderthals

Ancient DNA keeps expanding our understanding of complex genetic relationships between Pleistocene hominins. Here, Posth and colleagues analyse the mitochondrial genome of an archaic human that diverged from other Neanderthals ∼270,000 years ago, providing the minimum age for an African introgression into Neanderthals.

Cosimo Posth
Christoph Wißing
Johannes Krause
ResearchOpen Access04 Jul 2017
Nature Communications

Volume: 8, P: 1-9
Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study

Phase 1 trial results reveal that intrathecal transplantation of human fetal neural precursor cells in patients with progressive multiple sclerosis is feasible, safe and tolerable.

Angela Genchi
Elena Brambilla
Gianvito Martino
ResearchOpen Access09 Jan 2023
Nature Medicine

Volume: 29, P: 75-85
Learning the intrinsic dynamics of spatio-temporal processes through Latent Dynamics Networks

Predicting the evolution of dynamical systems remains challenging, requiring high computational effort or effective reduction of the system into a low-dimensional space. Here, the authors present a data-driven approach for predicting the evolution of systems exhibiting spatiotemporal dynamics in response to external input signals.

Francesco Regazzoni
Stefano Pagani
Alfio Quarteroni
ResearchOpen Access28 Feb 2024
Nature Communications

Volume: 15, P: 1-16
A fresh perspective on infrared spectroscopy as a prescreening method for molecular and stable isotopes analyses on ancient human bones

Cinzia Scaggion
Maurizio Marinato
Gilberto Artioli
ResearchOpen Access10 Jan 2024
Scientific Reports

Volume: 14, P: 1-14
A non-invasive tool for the early identification of children at risk of cardiometabolic dysfunction: data from the PODiaCar project

Valeria Calcaterra
Lucia Labati
Gianvincenzo Zuccotti
ResearchOpen Access03 Dec 2025
Pediatric Research

P: 1-9
Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma

Matteo Villa
Geeta G. Sharma
Luca Mologni
ResearchOpen Access30 Oct 2024
British Journal of Cancer

Volume: 131, P: 1781-1795
Cross-continental admixture in the Kho population from northwest Pakistan

Asifullah Khan
Leonardo Vallini
Shao-Qing Wen
Research25 Feb 2022
European Journal of Human Genetics

Volume: 30, P: 740-746
Differences in local population history at the finest level: the case of the Estonian population

Vasili Pankratov
Francesco Montinaro
Mait Metspalu
ResearchOpen Access25 Jul 2020
European Journal of Human Genetics

Volume: 28, P: 1580-1591
Multi-layered population structure in Island Southeast Asians

Alexander Mörseburg
Luca Pagani
Toomas Kivisild
Research15 Jun 2016
European Journal of Human Genetics

Volume: 24, P: 1605-1611
The key role of patrilineal inheritance in shaping the genetic variation of Dagestan highlanders

Laura Caciagli
Kazima Bulayeva
Sergio Tofanelli
Research13 Nov 2009
Journal of Human Genetics

Volume: 54, P: 689-694
Basal and IL-1β enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKKα and IKKβ NF-κB activating kinases

Eleonora Olivotto
Manuela Minguzzi
Rosa Maria Borzì
ResearchOpen Access04 Nov 2021
Scientific Reports

Volume: 11, P: 1-15
Ancient and recent admixture layers in Sicily and Southern Italy trace multiple migration routes along the Mediterranean

Stefania Sarno
Alessio Boattini
Davide Pettener
ResearchOpen Access16 May 2017
Scientific Reports

Volume: 7, P: 1-12
A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes

The authors developed a novel simplified assay for glioblastoma transcriptional classification on formalin-fixed-paraffin-embedded tissue samples. On such dataset, immunohistochemical profiles, based on expression of a restricted panel of gene classifiers, were integrated by machine learning approach to generate a glioblastoma transcriptional signature based on protein quantification that allowed to efficiently assign transcriptional subgroups to an extended cohort. Correlations with both histopathological features and clinical outcome have been also performed.

Francesca Orzan
Francesca Pagani
Pietro Luigi Poliani
Research13 May 2020
Laboratory Investigation

Volume: 100, P: 1330-1344
Ancestral genetic components are consistently associated with the complex trait landscape in European biobanks

Vasili Pankratov
Massimo Mezzavilla
Davide Marnetto
ResearchOpen Access10 Aug 2024
European Journal of Human Genetics

Volume: 32, P: 1492-1499
Author Correction: The genetic legacy of continental scale admixture in Indian Austroasiatic speakers

Kai Tätte
Luca Pagani
Mait Metspalu
Amendments and CorrectionsOpen Access10 Apr 2019
Scientific Reports

Volume: 9, P: 1
Correction: Corrigendum: Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal

Davide S. Risso
Massimo Mezzavilla
Dennis Drayna
Amendments and CorrectionsOpen Access27 Jun 2016
Scientific Reports

Volume: 6, P: 1
Cross-cultural data on romantic love and mate preferences from 117,293 participants across 175 countries

Marta Kowal
Piotr Sorokowski
Filipe Prazeres
ResearchOpen Access01 Jul 2025
Scientific Data

Volume: 12, P: 1-12
Morphological and evolutionary insights into the keystone element of the human foot’s medial longitudinal arch

A GM study diachronically examined evolution of the medial longitudinal arch and variation as expressed by the navicular bone, identifying navicular traits associated with particular locomotor behaviors, subsistence strategies, and foot types

Rita Sorrentino
Kristian J. Carlson
Stefano Benazzi
ResearchOpen Access19 Oct 2023
Communications Biology

Volume: 6, P: 1-13
Phylogenetic history of patrilineages rare in northern and eastern Europe from large-scale re-sequencing of human Y-chromosomes

Anne-Mai Ilumäe
Helen Post
Richard Villems
Research07 May 2021
European Journal of Human Genetics

Volume: 29, P: 1510-1519
Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer

Tania Velletri
Carlo Emanuele Villa
Giuseppe Testa
ResearchOpen Access29 Nov 2021
Cell Death & Differentiation

Volume: 29, P: 614-626
Genomic approaches to identify hybrids and estimate admixture times in European wildcat populations

Federica Mattucci
Marco Galaverni
Romolo Caniglia
ResearchOpen Access12 Aug 2019
Scientific Reports

Volume: 9, P: 1-15
The genetic legacy of continental scale admixture in Indian Austroasiatic speakers

Kai Tätte
Luca Pagani
Mait Metspalu
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Amendments and CorrectionsOpen Access17 Mar 2021
Nature

Volume: 592, P: E8
Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations

Christina A. Eichstaedt
Luca Pagani
Toomas Kivisild
ResearchOpen Access12 Oct 2017
Scientific Reports

Volume: 7, P: 1-9
Overcoming the dichotomy between open and isolated populations using genomic data from a large European dataset

Paolo Anagnostou
Valentina Dominici
Sergio Tofanelli
ResearchOpen Access01 Feb 2017
Scientific Reports

Volume: 7, P: 1-13
The genetic variation in the R1a clade among the Ashkenazi Levites’ Y chromosome

Doron M. Behar
Lauri Saag
Richard Villems
ResearchOpen Access02 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal

Davide S. Risso
Massimo Mezzavilla
Dennis Drayna
ResearchOpen Access03 May 2016
Scientific Reports

Volume: 6, P: 1-9
Selective sweep on human amylase genes postdates the split with Neanderthals

Charlotte E. Inchley
Cynthia D. A. Larbey
Toomas Kivisild
ResearchOpen Access17 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
LifeTime and improving European healthcare through cell-based interceptive medicine

The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Reviews07 Sept 2020
Nature

Volume: 587, P: 377-386
Uncertainty quantification of multi-scale resilience in networked systems with nonlinear dynamics using arbitrary polynomial chaos

Mengbang Zou
Luca Zanotti Fragonara
Weisi Guo
ResearchOpen Access10 Jan 2023
Scientific Reports

Volume: 13, P: 1-16

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