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Showing 1–11 of 11 results
Advanced filters: Author: Lui G. Forni Clear advanced filters

  • Here, the authors provide guidance on the prevention, diagnosis and management of anticancer therapy nephrotoxicity in adult patients. They also define a research agenda focused on preventing and mitigating anticancer therapy toxicity, maximizing early detection of nephrotoxicity and enabling optimal drug dosing in patients with kidney disease.

    • Amanda DeMauro Renaghan
    • Marlies Ostermann
    • Mitchell H. Rosner
    Reviews
    Nature Reviews Nephrology
    P: 1-18

  • Fluid therapy with saline is considered by some to confer a notable risk of acute kidney injury and mortality. However, data from the SPLIT trial — the first large, randomized controlled trial to compare saline to a 'balanced' solution — do not indicate any marked signal of harm in critically ill patients.

    • Michael Joannidis
    • Lui G. Forni
    News & Views
    Nature Reviews Nephrology
    Volume: 12, P: 6-8

  • The IDEAL-ICU study reports no mortality benefit of early versus delayed initiation of renal replacement therapy (RRT) in patients with early septic shock and acute kidney injury. In the delayed initiation group, 17% of patients required emergency RRT but more than one-third spontaneously recovered renal function and did not require RRT.

    • Lui G. Forni
    • Michael Joannidis
    News & Views
    Nature Reviews Nephrology
    Volume: 15, P: 5-6

  • Acute kidney injury (AKI) and chronic kidney disease are increasingly recognized as interconnected entities and the term acute kidney disease (AKD) has been proposed to define ongoing pathophysiologic processes following an episode of AKI. In this Consensus statement, the Acute Disease Quality Initiative 16 Workgroup propose definitions and staging criteria for AKD, and strategies for the management of affected patients. They also make recommendations for areas of future research with the aims of improving understanding of the underlying processes and improving outcomes.

    • Lakhmir S. Chawla
    • Rinaldo Bellomo
    • John A. Kellum
    ReviewsOpen Access
    Nature Reviews Nephrology
    Volume: 13, P: 241-257

  • COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and is an independent risk factor for all-cause in-hospital death in patients with COVID-19. This Consensus Statement from the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI and for areas of future research, with the aim of improving understanding of the underlying processes and outcomes for patients with COVID-19 AKI.

    • Mitra K. Nadim
    • Lui G. Forni
    • John A. Kellum
    ReviewsOpen Access
    Nature Reviews Nephrology
    Volume: 16, P: 747-764

  • Several factors complicate the identification of effective interventions that can improve the outcomes of patients with acute kidney injury (AKI). Here, the authors discuss key design considerations for clinical trials in hospitalized patients with AKI, including the selection of adequate patient cohorts and study end points.

    • Alexander Zarbock
    • Lui G. Forni
    • John A. Kellum
    Reviews
    Nature Reviews Nephrology
    Volume: 20, P: 137-146

  • The development of acute kidney injury (AKI) after major non-cardiac surgery is associated with substantial long-term morbidity and mortality. This joint Consensus Statement from the Acute Disease Quality Initiative and the PeriOperative Quality Initiative provides recommendations for the definition, prevention and management of postoperative AKI.

    • John R. Prowle
    • Lui G. Forni
    • John A. Kellum
    ReviewsOpen Access
    Nature Reviews Nephrology
    Volume: 17, P: 605-618

  • Sepsis-associated acute kidney injury (SA-AKI) is linked with poor outcomes in critically ill patients. This Consensus Statement from the Acute Disease Quality Initiative discusses the definition, epidemiology and pathophysiology of SA-AKI, fluid, resuscitation and extracorporeal therapies, and the role of biomarkers in risk stratification and diagnosis.

    • Alexander Zarbock
    • Mitra K. Nadim
    • Lui G. Forni
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 401-417

  • Acute kidney injury (AKI) is a common complication of COVID-19. This Review describes current understanding of the pathophysiology of COVID-19-associated AKI, examining potential mechanisms by which SARS-CoV-2 infection might induce direct and indirect effects on the kidney and non-specific factors, including haemodynamic changes and/or organ crosstalk, that may adversely influence kidney function.

    • Matthieu Legrand
    • Samira Bell
    • Vincenzo Cantaluppi
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 751-764