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Retraction Note: Microglia-dependent synapse loss in type I interferon-mediated lupus

Allison R. Bialas
Jessy Presumey
Michael C. Carroll
Amendments and Corrections05 Feb 2020
Nature

Volume: 578, P: 177
Tunable dynamics of B cell selection in gut germinal centres

Antibody selection and maturation within B cells found in gut-associated germinal centres is stimulated by the gut microbiota, to a degree that depends on the presence and composition of the microbes.

Carla R. Nowosad
Luka Mesin
Gabriel D. Victora
Research28 Oct 2020
Nature

Volume: 588, P: 321-326
Transient silencing of hypermutation preserves B cell affinity during clonal bursting

B cell germinal centres achieve a balance between clonal expansion and sequence diversification by suppressing somatic hypermutation during proliferative clonal bursts.

Juhee Pae
Niklas Schwan
Gabriel D. Victora
ResearchOpen Access19 Mar 2025
Nature

Volume: 641, P: 486-494
Molecular fate-mapping of serum antibody responses to repeat immunization

Serum antibody responses to sequential homologous booster vaccines derive overwhelmingly from primary cohort B cells at the expense of de novo responses; this ‘primary addiction’ can be overcome by boosting with variant antigens.

Ariën Schiepers
Marije F. L. van ’t Wout
Gabriel D. Victora
Research16 Jan 2023
Nature

Volume: 615, P: 482-489
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

Multi-modal profiling reveals major alterations in colonic B cells in patients with ulcerative colitis, including reduced clonal diversity of plasma cells, and suggests that circulating gut-homing plasmablasts could serve as a biomarker for disease activity.

Mathieu Uzzan
Jerome C. Martin
Saurabh Mehandru
Research21 Feb 2022
Nature Medicine

Volume: 28, P: 766-779
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells

Coeliac disease is characterized by an inappropriate immune response to dietary gluten proteins, involving the production of antibodies reactive to gluten. Here, the authors study the intestinal antibody response against gluten and show that gluten-specific antibodies have a low degree of somatic hypermutations.

Øyvind Steinsbø
Carole J. Henry Dunand
Ludvig M. Sollid
ResearchOpen Access09 Jun 2014
Nature Communications

Volume: 5, P: 1-12
Compartmentalized gut lymph node drainage dictates adaptive immune responses

Immune responses in the gut and associated draining lymph nodes differ between tolerogenic and inflammatory depending on their anatomical location.

Daria Esterházy
Maria C. C. Canesso
Daniel Mucida
Research15 Apr 2019
Nature

Volume: 569, P: 126-130
Microglia-dependent synapse loss in type I interferon-mediated lupus

Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.

Allison R. Bialas
Jessy Presumey
Michael C. Carroll
Research14 Jun 2017
Nature

Volume: 546, P: 539-543
High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions

IgA antibodies directed against tissue transglutaminase 2 (TG2) are used as a serological marker of celiac disease. Ludvig M. Sollid and his colleagues provide an unbiased and thorough characterization of the mucosal antibody response directly from the effector compartment. They report that TG2-specific plasma cells are expanded in the duodenal mucosa of individuals with celiac disease. Antibodies cloned from these cells are of high affinity, show a restricted repertoire and minimal somatic hypermutation, and do not inhibit TG2 enzymatic activity.

Roberto Di Niro
Luka Mesin
Ludvig M Sollid
Research26 Feb 2012
Nature Medicine

Volume: 18, P: 441-445

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