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Showing 51–100 of 108 results

Advanced filters: Author: Luke Gilbert Clear advanced filters

The DNA methylation landscape of advanced prostate cancer

Whole-genome bisulfite sequencing along with whole-genome and transcriptome sequencing of 100 prostate cancer metastases identifies genomic regions that are differentially methylated during disease progression and a novel epigenomic subtype.

Shuang G. Zhao
William S. Chen
Felix Y. Feng
Research13 Jul 2020
Nature Genetics

Volume: 52, P: 778-789
Safety and efficacy of a continuous infusion, patient controlled anti-emetic pump to facilitate outpatient administration of high-dose chemotherapy

SP Dix
MK Cord
RB Geller
Research08 Sept 1999
Bone Marrow Transplantation

Volume: 24, P: 561-566
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Understanding the effect of vaccination on emerging SARS-CoV-2 variants of concern is of increasing importance. Here, James et al. report that two doses of vaccination with the Pfizer-BioNTech vaccine induce more robust immune responses to the B.1.1.7 and B.1.351 SARS-CoV-2 lineages than does natural infection.

Donal T. Skelly
Adam C. Harding
William S. James
ResearchOpen Access17 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Three-dimensional neutron far-field tomography of a bulk skyrmion lattice

The three-dimensional spin textures of a skyrmion lattice have now been measured in a bulk material using a tomographic small-angle neutron scattering technique.

M. E. Henderson
B. Heacock
D. A. Pushin
ResearchOpen Access14 Aug 2023
Nature Physics

Volume: 19, P: 1617-1623
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
Divergent trajectories of antiviral memory after SARS-CoV-2 infection

The engagement of immunological memory is a key component to the protective anti-SARS-CoV-2 B and T cell responses. Here the authors assess the B and T cells of a cohort of UK healthcare workers in response to infection and longitudinally track the compartment showing distinct trajectories following early priming.

Adriana Tomic
Donal T. Skelly
Susanna J. Dunachie
ResearchOpen Access10 Mar 2022
Nature Communications

Volume: 13, P: 1-20
Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity

This Resource combines amplicon sequencing, shotgun metagenomic sequencing and untargeted metabolomics to provide a global view of microbial–metabolite associations across Earth’s environments.

Justin P. Shaffer
Louis-Félix Nothias
Shan Zhang
ResearchOpen Access28 Nov 2022
Nature Microbiology

Volume: 7, P: 2128-2150
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

A combination of shRNA- and CRISPR-Cas9-based gene editing screens, corroborated by a metabolite suppression experiment identifies the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH) as the target of the broad-spectrum antiviral compound GSK983.

Richard M Deans
David W Morgens
Michael C Bassik
Research28 Mar 2016
Nature Chemical Biology

Volume: 12, P: 361-366
A new era in functional genomics screens

In this Review, Przybyla and Gilbert describe the latest approaches for CRISPR-based functional genomics screens, including the adoption of single-cell transcriptomic read-outs and applications in characterizing the non-coding genome and mapping genetic interactions at scale.

Laralynne Przybyla
Luke A. Gilbert
Reviews20 Sept 2021
Nature Reviews Genetics

Volume: 23, P: 89-103
Vertical structure of Caribbean deep-reef fishes from the altiphotic to deep-sea boundary

Juliette Jacquemont
Simon J. Brandl
Luke Tornabene
ResearchOpen Access22 Aug 2024
Scientific Reports

Volume: 14, P: 1-16
Neoantigen-directed immune escape in lung cancer evolution

RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.

Rachel Rosenthal
Elizabeth Larose Cadieux
Andrew Kidd
Research20 Mar 2019
Nature

Volume: 567, P: 479-485
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Analysis of whole-genome doubling (WGD) by using cancer sequencing data combined with simulations of tumor evolution suggests that there is negative selection against homozygous loss of essential genes before WGD but not after.

Saioa López
Emilia L. Lim
Nicholas McGranahan
Research05 Mar 2020
Nature Genetics

Volume: 52, P: 283-293
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Reducing the burden of HIV/AIDS in infants: the contribution of improved diagnostics

The development of an inexpensive, simple and widely accessible test for diagnosing human immunodeficiency virus (HIV) infection in infants could significantly reduce paediatric acquired immunodeficiency syndrome (AIDS) deaths in sub-Saharan Africa.

Julia E. Aledort
Allan Ronald
Cathy Wilfert
Research22 Nov 2006
Nature

Volume: 444, P: 19-28
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1549-1559
Socioeconomic impact and burden of hypertension in the Philippines projected in 2050

Leilani B. Mercado-Asis
Deborah Ignacia D. Ona
Rafael R. Castillo
Research14 Oct 2022
Hypertension Research

Volume: 46, P: 244-252
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

Yanick J Crow
Andrea Leitch
Andrew P Jackson
Research16 Jul 2006
Nature Genetics

Volume: 38, P: 910-916
The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men

Tomoko Kuroda-Kawaguchi
Helen Skaletsky
David C. Page
Research22 Oct 2001
Nature Genetics

Volume: 29, P: 279-286
A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

Alex Y. Ge
Abolfazl Arab
Luke A. Gilbert
ResearchOpen Access29 Oct 2024
Scientific Reports

Volume: 14, P: 1-18
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
MorPhiC Consortium: towards functional characterization of all human genes

This Perspective discusses strategies and challenges for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Consortium as it aims to catalogue the molecular and cellular phenotypes associated with null alleles of all human genes.

Mazhar Adli
Laralynne Przybyla
Justina Žurauskienė
Reviews12 Feb 2025
Nature

Volume: 638, P: 351-359
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
A decade of seasonal dynamics and co-occurrences within freshwater bacterioplankton communities from eutrophic Lake Mendota, WI, USA

Emily L Kara
Paul C Hanson
Katherine D McMahon
Research11 Oct 2012
The ISME Journal

Volume: 7, P: 680-684
Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148
Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Francesca Chemi
Dominic G. Rothwell
Jason Lester
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1147
Potential pitfalls in the use of real-world data for studying long COVID

Harrison G. Zhang
Jacqueline P. Honerlaw
Gabriel A. Brat
Correspondence13 Apr 2023
Nature Medicine

Volume: 29, P: 1040-1043
International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality

Griffin M. Weber
Chuan Hong
Gabriel A. Brat
ResearchOpen Access13 Jun 2022
npj Digital Medicine

Volume: 5, P: 1-8
Further evidence supporting a potential role for ADH1B in obesity

Liza D. Morales
Douglas T. Cromack
Christopher P. Jenkinson
ResearchOpen Access21 Jan 2021
Scientific Reports

Volume: 11, P: 1-14
Objectively measured moderate-to-vigorous physical activity does not attenuate prospective weight gain among african-origin adults spanning the epidemiological transition

Jessica C. Davies
Candice Choo-Kang
Lara R. Dugas
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Quorum sensing protects bacterial co-operation from exploitation by cheats

Richard C Allen
Luke McNally
Sam P Brown
ResearchOpen Access08 Jan 2016
The ISME Journal

Volume: 10, P: 1706-1716
The unequal burden of human-wildlife conflict

The costs of human-wildlife conflict are measurably more impactful in areas of the developing world where the loss of cattle can mean the entire livelihood of a family being erased.

Alexander R. Braczkowski
Christopher J. O’Bryan
Duan Biggs
ResearchOpen Access23 Feb 2023
Communications Biology

Volume: 6, P: 1-9
A clonal expression biomarker associates with lung cancer mortality

TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1540-1548
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Pulmonary venous tumor cells disseminating before tumor resection are heterogeneous, predict relapse and seed future metastasis of lung cancer

Francesca Chemi
Dominic G. Rothwell
Jason Lester
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1534-1539
Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

Trang T. Le
Alba Gutiérrez-Sacristán
Zongqi Xia
ResearchOpen Access12 Oct 2021
Scientific Reports

Volume: 11, P: 1-13
Responding to the challenge of diabetic nephropathy: the historic evolution of detection, prevention and management

JP Vora
HAA Ibrahim
GL Bakris
Reviews18 Oct 2000
Journal of Human Hypertension

Volume: 14, P: 667-685
The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ghorani et al. use a multiomics approach to characterize the effect of tumour mutational burden on the differentiation of CD4 and CD8 T cell subpopulations in non-small cell lung cancer.

Ehsan Ghorani
James L. Reading
Sergio A. Quezada
Research22 May 2020
Nature Cancer

Volume: 1, P: 546-561
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

Multiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions

Khalid AbdulJabbar
Shan E. Ahmed Raza
Yinyin Yuan
Research27 May 2020
Nature Medicine

Volume: 26, P: 1054-1062
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide association study of pancreatitis. They identify common variants at two loci associated with risk of this disease, including one on the X chromosome that shows strong evidence of interaction with alcohol consumption.

David C Whitcomb
Jessica LaRusch
Bernie Devlin
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1349-1354
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148
Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women

Lara R. Dugas
Beatriz Peñalver Bernabé
Brian T. Layden
ResearchOpen Access20 Nov 2018
Scientific Reports

Volume: 8, P: 1-17
Anoxic carbon flux in photosynthetic microbial mats as revealed by metatranscriptomics

Luke C Burow
Dagmar Woebken
Steven W Singer
Research29 Nov 2012
The ISME Journal

Volume: 7, P: 817-829
Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy

I Chau
A R Norman
J R Oates
ResearchOpen Access14 Sept 2004
British Journal of Cancer

Volume: 91, P: 1453-1458

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