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Advanced filters: Author: Mélina Vaurs Clear advanced filters

  • Telomere replication poses unique challenges. Here, the authors show that TRF1 prevents telomere fragility by promoting replication fork reversal, a process dependent on RNA:DNA hybrids and necessary for TFIIH-mediated restart of leading strand synthesis. When fork reversal is impaired, PrimPol serves as a compensatory mechanism.

    • Mélina Vaurs
    • Eloïse Claude
    • Anabelle Decottignies
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17