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The two species of African elephants are facing severe declines. Here, authors assess their continent-wide genomic diversity, identifying differences in their evolutionary histories and highlighting the formative role of gene flow.

Hepatitis C virus remains a health burden due to the lack of an effective vaccine, hindered by difficulties in replicating the native E1E2 antigen structure. Here, the authors engineer a stabilized E1E2 heterodimer using cryo-EM-guided modifications, enhancing immunogenicity and paving the way for future HCV vaccine development.

The authors report Acheulean hominin occupation of eastern Britain during glacial marine isotope stages 17–16 and again in glacial marine isotope stage 12 via stone tools in sediments dated to 712,000 to 424,000 years ago.

The authors resolve 63 structurally diverse haplotype structures for the 22q11.2 deletion syndrome region. Deletion risk differs depending on structure; individuals of African ancestry are enriched for inverted repeats that predispose to inversion.

The Scalesia plant radiation displays striking leaf-shape variation within Galápagos microclimates. Genome-wide analyses shows that lobed leaves evolved repeatedly through diversifying selection on diverse developmental regulators.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

The authors display a comprehensive study on the manipulation of topology and altermagnetism by controlling the hybridization of the surface states and the Fermi level of topological insulators.

Less than 15% of people in 862 European cities live in full compliance with the 3-30-300 greening rule. Wealthier areas show higher adherence, highlighting urgent needs for equitable urban planning to improve access to green spaces.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

Kancharla, Kelly et al. identify an acridone antimalarial potent across all major parasite life stages. Lead candidate T111 shows oral efficacy, low toxicity, and synergy with tafenoquine, providing a unique mechanism to overcome resistance.

Deletion of one allele of Rps19 or Rpl5 highlights how ribosomal proteins control fetal hematopoiesis. Imbalanced ribosomal protein stoichiometry disrupts developmental programs leading to pediatric disorders known as ribosomopathies.

Acute rheumatic fever (ARF) is a serious sequela of Strep A infection, for which a diagnostic biomarker is still lacking. Here, the authors demonstrate that CXCR3 directs T cells to heart valves in patients with ARF, linking inflammation to tissue damage.

Neutrophil accumulation in the ischemic heart occurs rapidly after myocardial infarction, but their early origin has been unclear. Here, the authors show that β2-adrenergic signaling drives stress-induced demargination of vascular neutrophils, supplying the first wave of early post-MI neutrophils.

ZY19489 is a potent antimalarial candidate, which shows a low resistance liability, mediated by a fitness-compromising mutation in PfCRT that restores Plasmodium falciparum susceptibility to the licensed drug piperaquine by blocking its efflux.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

FLT3-ITD mutations drive relapse in acute myeloid leukemia (AML) despite targeted therapies. This group studies therapeutic potential and resistance mechanisms of FLT3-ITD inhibition with QUIZartinib and Omacetaxine Mepesuccinate (QUIZOM) in preclinical and clinical AML specimens.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Urban ecology traditionally focuses on single cities, yet cities play key roles in ecological processes such as migration. Radar analysis across the continental USA reveals that nearly half of stopover hotspots concentrate in metropolitan areas, linked to urbanization.

Transmission of Plasmodium falciparum relies on the development of gametocytes, which undergo extensive cellular remodelling. Here, the authors demonstrate that the PfGID E3 ubiquitin ligase complex affects gametocyte development by regulating key proteins, producing defective cells that cannot infect mosquitoes.

Integration of mosquito and non-human primate surveillance and viral metagenomics reveals yellow fever virus outbreak dynamics at an urban–forest interface in Brazil.

Pancreatic ductal adenocarcinoma carries a poor prognosis, with pancreatectomy as the only potentially curative option. This Phase II trial assessed distant metastasis-free survival in locally advanced disease using GVAX vaccine, pembrolizumab, and SBRT following chemotherapy.

The authors show that, when looking at differential methylation, assessing relative changes rather than absolute changes finds more biologically relevant targets.

Variation in responses to bacterial and viral stimuli between Batwa rainforest hunter-gatherers and Bakiga agriculturalists from Uganda suggests population-level divergence under natural selection, with hunter-gatherers disproportionately showing signatures of positive selection.

Ozone-depleting substances (ODS) are banned from emissive uses. However, they are still allowed to be used as feedstocks and ODS emissions from this source have been higher than assumed. This could delay the recovery of the stratospheric ozone layer.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Store-operated Ca²⁺ entry is essential for cellular signalling, yet excessive calcium influx drives disease. Here, authors develop genetically encoded CRAC channel inhibitory binders (CRABs) to precisely modulate Ca²⁺ signalling, with therapeutic potential in channelopathies and cancer immunotherapy.

Two individuals with KCNT1-related epileptic encephalopathy were treated with a KCNT1-targeting antisense oligonucleotide, leading to significant reductions in seizure frequency and intensity, but also the development of hydrocephalus.

Here, the authors investigate the mechanism by which human aspartate/asparagine-β-hydroxylase (AspH), a 2OG-dependent oxygenase with an atypical Fe(II) coordination environment, catalyses hydroxylation of aspartate and asparagine residues in epidermal growth factor-like domains.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Allosteric biosensors are constructed by combining reporter proteins with machine-learning-designed receptor domains.

Membrane-based separation methods are promising for ion extraction, though current commercial membranes have unfavorable selectivity among similar ions. Here the authors design a crown-ether based membrane for preferential separation of potassium ions in mixtures of monovalent and divalent cations.

Global travel hubs could be key in future pandemic surveillance efforts. Here, using a global metapopulation model calibrated to epidemiology, phylogeography and air travel, the authors show that traveler-focused genomic surveillance at key hubs can speed up detection of SARS-CoV-2 variants under resource constraints.

A self-powered platform integrates graphene-based ion-sensitive field-effect transistors, MoS₂ electronic circuits and silicon photovoltaics to digitize diverse liquid analytes under ambient light, enabling compact, autonomous, battery-free chemical analysis.

Baum et al. present a synthesis of field data, remote-sensed data, media reports and process-based modelling analyses examining the effects of the 2021 heatwave in western North America for 32 terrestrial and marine taxa as well as gross primary productivity, streamflow and wildfire activity.

In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Assessment of how 16 taxonomic groups in a lowland tropical forest resist and recover from anthropogenic disturbance shows the potential of protecting naturally regenerating secondary forests to reverse biodiversity losses.

Appel et al. found that deceptive networks reached over 37 million Facebook and 3 million Instagram users during the 2020 US elections, with the majority of this exposure driven by 3 networks and amplified by ordinary users resharing the content.

The electronic behaviour of complex oxides such as LaNiO₃ depends on many intrinsic and extrinsic factors, making it challenging to identify microscopic mechanisms. Here the authors demonstrate the influence of oxygen vacancies on the thickness-dependent metal-insulator transition of LaNiO₃ films.

Myeloid derived suppressor cells (MDSC) use different metabolic mechanisms to adapt to the tumour microenvironment. Here the authors show that 6-phosphogluconate dehydrogenase (6PGD) is important for MSDC function and that blockade of 6PGD impaired MDSC function and suppresses tumour growth leading to metabolic and functional changes in the MDSC and a more pro-inflammatory phenotype.