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Showing 1–50 of 65 results

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Maximizing response to intratumoral immunotherapy in mice by tuning local retention

Understanding the pharmacokinetics of locally-injected drugs could aid in the design of immunotherapies to maximize their therapeutic effect. Here, by evaluating different IL-2 fusion proteins, the authors show that molecular weight and matrix binding affect anti-tumor immune response and report a pharmacokinetic framework to predict response to intratumoral IL-2 therapy.

Noor Momin
Joseph R. Palmeri
K. Dane Wittrup
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism

Omar M. Elsayed
Samy A. Abdelazim
Mahmoud A. Senousy
ResearchOpen Access02 Jan 2023
Scientific Reports

Volume: 13, P: 1-13
CD8⁺ T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs

Antibodies stimulating the T cell co-activator 4-1BB (CD137) do enhance anti-tumour T cell function, but their utility is hampered by on target, off tumor toxicity. Here authors show that anchoring anti-4-1BB to tumours via fusion with the collagen binding protein LAIR diminishes systemic dissemination of the drug, and they demonstrate a curative effect in a triple-combination-therapy that relieves regulatory T cell immunosuppression in a mouse model of cancer.

Joseph R. Palmeri
Brianna M. Lax
K. Dane Wittrup
ResearchOpen Access01 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice

Guilielmus H. J. M. Ellenbroek
Judith J. de Haan
Saskia C. A. de Jager
ResearchOpen Access21 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division

A Poggi
S Catellani
M R Zocchi
Research21 Feb 2008
Leukemia

Volume: 22, P: 980-988
Aboriginal mitogenomes reveal 50,000 years of regionalism in Australia

Analysis of Aboriginal Australian mitochondrial genomes shows geographic patterns and deep splits across the major haplogroups that indicate a single, rapid migration along the coasts around 49–45 ka, followed by longstanding persistence in discrete geographic areas.

Ray Tobler
Adam Rohrlach
Alan Cooper
Research08 Mar 2017
Nature

Volume: 544, P: 180-184
Inhibitory pattern recognition receptors: lessons from LAIR1

Pattern recognition receptors (PRRs) are typically associated with innate immune activation, but there is an emerging subset of inhibitory pattern recognition receptors (iPRRs) that limit cell activation. This Review from Meyaard and colleagues highlights our growing understanding of iPRR biology, focusing on leukocyte-associated immunoglobulin-like receptor (LAIR1).

M. Inês Pascoal Ramos
Michiel van der Vlist
Linde Meyaard
Reviews27 May 2025
Nature Reviews Immunology

Volume: 25, P: 711-724
Controversial cheetahs?

M. Karen Laurenson
T. M. Caro
N. Wielebnowski
Research05 Oct 1995
Nature

Volume: 377, P: 392
Distinct Expression of Inhibitory Immune Receptors on Neonatal Innate Immune Cells

J Walk
G H A Westerlaken
L J Bont
Research01 Nov 2011
Pediatric Research

Volume: 70, P: 494
Humans rather than climate the primary cause of Pleistocene megafaunal extinction in Australia

Megafaunal extinction in Australia has been attributed to both climate change and human causation. Here, van der Kaarset al. present a 150,000 year record offshore southwest Australia in which they refine the timing and nature of regional ecosystem changes and megafaunal population collapse.

Sander van der Kaars
Gifford H. Miller
Scott J. Lehman
ResearchOpen Access20 Jan 2017
Nature Communications

Volume: 8, P: 1-7
The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

Zhang and colleagues show that the ITIM-containing receptor LAIR1 supports self-renewal and survival of acute myeloid leukaemia stem cells through a signalling pathway that includes the SHP-1 phosphatase, CAMK1 kinase and CREB transcription factor.

Xunlei Kang
Zhigang Lu
Cheng Cheng Zhang
Research27 Apr 2015
Nature Cell Biology

Volume: 17, P: 665-677
Band Systems of Zirconium Oxide (ZrO) in the Ultra-Violet

M. AFAF
Research29 Oct 1949
Nature

Volume: 164, P: 752-753
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes

Aspergillomarasmine A (AMA) chelates metal ions such as Zn²⁺ and Ni²⁺, which are essential for the activity of enzymes that are important for virulence of several pathogens. Here, Sychantha et al. show that AMA inhibits bacterial Ni²⁺ uptake and Ni-dependent enzymes, and reduces bacterial virulence in an animal infection model.

David Sychantha
Xuefei Chen
Gerard D. Wright
ResearchOpen Access13 May 2024
Nature Communications

Volume: 15, P: 1-14
Immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factors

Barcia Durán, Dayasagar, et al. map the expression of immune checkpoints in human atherosclerosis and examine the influence of lipid-lowering treatments and type 2 diabetes to understand how immune checkpoint inhibitors worsen cardiovascular risk in survivors of cancer.

José Gabriel Barcia Durán
Dayasagar Das
Chiara Giannarelli
ResearchOpen Access29 Nov 2024
Nature Cardiovascular Research

Volume: 3, P: 1482-1502
LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR

Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the transporter domain is similar to the plant PIN family.

Charles Bayly-Jones
Christopher J. Lupton
Andrew M. Ellisdon
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 1238-1244
Tyrosinase Activity in the Amelanotic Melanoma in Golden Hamsters

ELŻBIETA DERNAŁOWICZ
JERZY TROJANOWSKI
TADEUSZ DOMINICZAK
Research08 Jul 1967
Nature

Volume: 215, P: 188-189
The DNA sequence and biology of human chromosome 19

Jane Grimwood
Laurie A. Gordon
Susan M. Lucas
Research01 Apr 2004
Nature

Volume: 428, P: 529-535
A 300 kilobase interval genetic map of rice including 883 expressed sequences

N. Kurata
Y. Nagamura
Y. Minobe
Research01 Dec 1994
Nature Genetics

Volume: 8, P: 365-372
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936

Plasma levels of neurological proteins have the potential to serve as biomarkers for neurological conditions. Here, Hillary et al. perform genome- and epigenome-wide association studies for 92 neurological proteins and identify 41 genomic loci for 33 proteins and 26 CpG sites for 9 proteins.

Robert F. Hillary
Daniel L. McCartney
Riccardo E. Marioni
ResearchOpen Access18 Jul 2019
Nature Communications

Volume: 10, P: 1-9
Antibodies to melanoma cell and BCG antigens in sera from tumour-free individuals and from melanoma patients

P. MINDEN
C. JARRETT
E. M. HERSH
Research28 Oct 1976
Nature

Volume: 263, P: 774-777
Gpcpd1–GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism

Cikes et al. report dysregulation of glycerophosphocholine (GPC) metabolism in aged mouse muscle, which they functionally link to severe glucose intolerance. Correspondingly, muscle GPC levels are altered in both older adults and patients with type 2 diabetes.

Domagoj Cikes
Michael Leutner
Josef M. Penninger
Research18 Jan 2024
Nature Aging

Volume: 4, P: 80-94
Continuous Production of a Novel Lysozyme via Secretion from the Yeast, Pichia pastoris

M. E. Digan
S. V. Lair
G. P. Thill
Research01 Feb 1989
Bio/Technology

Volume: 7, P: 160-164
Shaving to Impress

R. M. HARDISTY
Correspondence27 Jun 1970
Nature

Volume: 226, P: 1277
CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels

This study identifies CSF proteins specifically dysregulated along the AD continuum that reflect the multifactorial nature of disease progression. Some of these CSF proteins were used to build biomarker panels with high diagnostic accuracies.

Marta del Campo
Carel F. W. Peeters
Charlotte E. Teunissen
Research10 Nov 2022
Nature Aging

Volume: 2, P: 1040-1053
Growth at 2 years in children born preterm: donor milk versus preterm formula

Jane E. Brumbaugh
Scott A. McDonald
Tarah T. Colaizy
Research19 Jan 2026
Pediatric Research

P: 1-10
Surface phenotypes of naive and memory B cells in mouse and human tissues

Weisel and colleagues provide a resource that phenotypically profiles naive and memory B cells and provides a comparative analysis of memory B cells found in humans versus mice.

Nadine M. Weisel
Stephen M. Joachim
Mark J. Shlomchik
Research22 Dec 2021
Nature Immunology

Volume: 23, P: 135-145
A novel data fusion method for the effective analysis of multiple panels of flow cytometry data

Gerjen H. Tinnevelt
Selma van Staveren
Jeroen J. Jansen
ResearchOpen Access01 May 2019
Scientific Reports

Volume: 9, P: 1-9
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4⁺ T cell reservoir

Betts and colleagues have developed a method for characterizing the HIV reservoir at the single-cell level to gain insight into the heterogeneous nature of CD4⁺ T cells harboring HIV-1 proviral DNA in patients undergoing antiretroviral treatment.

Vincent H. Wu
Jayme M. L. Nordin
Michael R. Betts
ResearchOpen Access19 Dec 2022
Nature Immunology

Volume: 24, P: 359-370
CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers

Shahzad Ahmad
Marta del Campo Milan
Cornelia M. van Duijn
ResearchOpen Access19 May 2020
Scientific Reports

Volume: 10, P: 1-13
Breaking Open The Bottlenecks In Genomic DNA Sequencing

Stephen M. Edgington
Research01 Jan 1993
Bio/Technology

Volume: 11, P: 39-42
Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases

Monique Lacroix
Agnès Tessier
Nicole M. Thielens
ResearchOpen Access05 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Sun–climate links

T. M. L. Wigley
News & Views27 Nov 1980
Nature

Volume: 288, P: 317-318
Colloid and Crystal Formation in Parotid Saliva of Cystic Fibrosis Patients and Non-Cystic Fibrosis Subjects. II. Electron Microscopy and Electrophoresis

Helen M Allars
David J H Cockayne
John M Brown
Research01 Jun 1976
Pediatric Research

Volume: 10, P: 584-594
Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue

A method to isolate and sequence individual nuclei from human and mouse muscle biopsies provides further insight into the mechanisms of dystrophin loss and repair, in the context of Duchenne muscular dystrophy.

Deirdre D. Scripture-Adams
Kevin N. Chesmore
M. Carrie Miceli
ResearchOpen Access19 Sept 2022
Communications Biology

Volume: 5, P: 1-14
High-Level Expression of Tetanus Toxin Fragment C in Pichia Pastoris Strains Containing Multiple Tandem Integrations of the Gene

J. J. Clare
F. B. Rayment
M. A. Romanos
Research01 May 1991
Bio/Technology

Volume: 9, P: 455-460
PROGRESSIVE BICYCLE EXERCISE IN ASTHMATIC CHILDREN

B Sablayrolles
M Plot
P Rochiccioli
Research01 Oct 1985
Pediatric Research

Volume: 19, P: 1119
IMMEDIATE TYPE HYPERSENSITIVITY TO OVALBUMIN IN INFANTS AND CHILDREN - A MODEL FOR THE STUDY OF FOOD ALLERGY

M Thiemeier
M Kemeny
U Wahn
Research01 Oct 1985
Pediatric Research

Volume: 19, P: 1119
Recent Advances in the Expression of Foreign Genes in Pichia pastoris

James M. Cregg
Thomas S. Vedvick
William C. Raschke
Reviews01 Aug 1993
Bio/Technology

Volume: 11, P: 905-910
Computer vision enables taxon-specific identification of African carnivore tooth marks on bone

Manuel Domínguez-Rodrigo
Marcos Pizarro-Monzo
Enrique Baquedano
ResearchOpen Access22 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
OUTCOME OF CARDIOPULMONARY RESUSCITATION IN THE NEONATAL INTENSIVE CARE UNIT

L D Willett
M P Leuschen
R M Nelson
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 355
Oerskovia xanthineolytica: a new pathogen in bone marrow transplantation

P Ellerbroek
S Kuipers
EJ Petersen
Research19 Aug 1998
Bone Marrow Transplantation

Volume: 22, P: 503-505
The complement system as a potential therapeutic target in rheumatic disease

In this review, the authors evaluate the association of complement activation with a variety of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus and small-vessel vascultis, and discuss whether complement inhibition has therapeutic potential in these diseases.

Leendert A. Trouw
Matthew C. Pickering
Anna M. Blom
Reviews10 Aug 2017
Nature Reviews Rheumatology

Volume: 13, P: 538-547
Maximum likelihood estimation of linkage between a marker gene and a quantitative locus

Z W Luo
M J Kearsey
Research01 Dec 1989
Heredity

Volume: 63, P: 401-408
Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures

Gaia Andreoletti et al. leverage cell-sorted RNA-seq data and machine learning to investigate gene expression patterns in immune cell subtypes purified from Asian and White patients with a medical diagnosis of systemic lupus erythematosus (SLE). They report distinct clinical subtypes of SLE and identify ethnicity- and disease-specific gene clusters, potentially contributing toward the future development of personalized therapeutic strategies for patients with SLE.

Gaia Andreoletti
Cristina M. Lanata
Marina Sirota
ResearchOpen Access21 Apr 2021
Communications Biology

Volume: 4, P: 1-13
Investigation of 91 proteins implicated in neurobiological processes identifies multiple candidate plasma biomarkers of stroke outcome

Cecilia Lagging
Sofia Klasson
Christina Jern
ResearchOpen Access22 Nov 2022
Scientific Reports

Volume: 12, P: 1-14
Induction of apoptosis by 2-chlorodeoxyadenosine in B cell chronic lymphocytic leukemia

R Castejón
JA Vargas
A Durántez
Research01 Aug 1997
Leukemia

Volume: 11, P: 1253-1257
Serial transplantation of a human T-cell acute lymphoblastic leukaemia line into nude mice

I Miyoshi
T Ota
I Kimura
Research01 Jul 1981
British Journal of Cancer

Volume: 44, P: 124-126
Genetic correlations and the evolution of photoperiodic time measurement within a local population of the pitcher-plant mosquito, Wyeomyia smithii

W E Bradshaw
K J Emerson
C M Holzapfel
Research09 Nov 2011
Heredity

Volume: 108, P: 473-479
Heterologous Gene Expression in Hansenula Polymorpha: Efficient Secretion of Glucoamylase

Gerd Gellissen
Zbigniew A. Janowicz
Alexander W.M. Strasser
Research01 Mar 1991
Bio/Technology

Volume: 9, P: 291-295
The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts

S Sparrow
M Jones
B Stace
Research01 Jun 1986
British Journal of Cancer

Volume: 53, P: 793-797

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