This paper implicates vascular-derived endothelins in axonal growth and guidance. It is shown that the origin of smooth muscle cells surrounding the internal and external carotids is different and finds that they preferentially express components of the endothelin ligand-receptor system. The endothelin family member ET3 directs axon extension of a subset of sympathetic neurons to the external carotid artery.
- Takako Makita
- Henry M. Sucov
- David D. Ginty
