In this Review, Corrigan and colleagues explore the broad range of metabolic pathways that guanosine pentaphosphate, guanosine tetraphosphate and guanosine 5′-monophosphate 3′-diphosphate regulate in the bacterial cell and emphasize the importance of these alarmones in regulating diverse metabolic processes. Moreover, they examine the contribution of these alarmones to virulence and chronic infection.
- Sophie E. Irving
- Naznin R. Choudhury
- Rebecca M. Corrigan