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Showing 1–50 of 101 results
Advanced filters: Author: M. Spate Clear advanced filters

  • In this work, authors show how the enterotoxigenic Escherichia coli (ETEC) protease EatA cleaves the human mucus protein MUC2 at a C-terminal site, allowing bacteria to cross the intestinal mucus, reach epithelial cells, and promote infection, as demonstrated using a human MUC2 transgenic mouse model.

    • Sergio Trillo-Muyo
    • Brendan Dolan
    • Sjoerd van der Post
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • Autotransporter passenger domains are presented on or released from the bacterial surface upon translocation through an outer membrane β-barrel anchor. Here the authors study the two E. coli autotransporters Pet and EspP and propose that the β-barrel anchor acts as a vector to nucleate the folding of the passenger domain.

    • Xiaojun Yuan
    • Matthew D. Johnson
    • Denisse L. Leyton
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • An outbreak of diarrhoea and haemolytic uraemic syndrome in Germany in 2011 was caused by a Shiga toxin-producing enteroaggregative E. coli, which carried the aggregative adherence plasmid pAA. Here, the authors show that autotransporters, but not pAA, are required for intestinal colonization in an infant rabbit model.

    • Diana Munera
    • Jennifer M. Ritchie
    • Matthew K. Waldor
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • Shigellainfection continues to have a high disease burden worldwide, especially in young children in developing countries. Here, the latest progress inShigella vaccine research is reviewed—including the identification of new vaccine antigens and technological advances in vaccine design and manufacture—as well as the barriers that impede the development of a successful Shigellavaccine.

    • Eileen M. Barry
    • Marcela F. Pasetti
    • Myron M. Levine
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 245-255

  • An increase in shigellosis cases among men who have sex with men in the United Kingdom has been linked to an extensively drug-resistant strain of Shigella sonnei. In this genomic epidemiology study, the authors investigate the genetic basis, evolutionary history, and international dissemination of the outbreak strain.

    • Lewis C. E. Mason
    • David R. Greig
    • Kate S. Baker
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Ice sheets are vulnerable to changes in the environment where ice discharges into the ocean. Here, the authors show that, in spite of widespread retreat following the last glacial maximum, a sub-sector of the East Antarctic Ice Sheet in the Ross Sea underwent sustained readvance.

    • Sarah L. Greenwood
    • Lauren M. Simkins
    • John B. Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • This study reports on excavations of hearths and stone artefacts from 20,000-year-old deposits at Dargan Shelter, which at an elevation of 1,073 m is believed to be the oldest occupied high-altitude site in Australia.

    • Amy M. Way
    • Philip J. Piper
    • Wayne Brennan
    ResearchOpen Access
    Nature Human Behaviour
    Volume: 9, P: 2471-2479

  • We reconstruct the spatial distribution and timing of wetland loss through conversion to seven human land uses between 1700 and 2020, elucidating the magnitude and land-use drivers of global wetland losses to improve assessments of wetland loss impacts.

    • Etienne Fluet-Chouinard
    • Benjamin D. Stocker
    • Peter B. McIntyre
    Research
    Nature
    Volume: 614, P: 281-286

  • Maldonado, Lopez-Hernandez, et al. use a matched case-control study to compare E. coli-infected patients with or without sepsis. Their analysis shows that the ST69 clone is associated with risk of sepsis development, and certain genetic factors such as adhesion genes papC and fdeC were associated with a protective effect.

    • Natalia Maldonado
    • Inmaculada López-Hernández
    • Juan Pasquau
    ResearchOpen Access
    Communications Medicine
    Volume: 6, P: 1-11

  • In the scramble to achieve net-zero emissions by 2050, many nations are examining their agriculture and land-use sectors. In Ireland, while net-zero emissions by 2050 are feasible through a reduction in meat and dairy production and smart land management, carbon neutrality beyond 2050 may prove fleeting.

    • Colm Duffy
    • Remi Prudhomme
    • David Styles
    Research
    Nature Sustainability
    Volume: 5, P: 973-980

  • Our understanding of the origin of jaws is hampered by the poor fossil preservation of pharyngeal morphology. Here, Dearden et al. provide insight into the skull conditions of early jawed vertebrates through three-dimensional computed tomography imaging of a 415 million year old stem-chondrichthyan.

    • Richard P. Dearden
    • Christopher Stockey
    • Martin D. Brazeau
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7

  • Was sonar responsible for a spate of whale deaths after an Atlantic military exercise?

    • P. D. Jepson
    • M. Arbelo
    • A. Fernández
    Research
    Nature
    Volume: 425, P: 575-576

  • Bacterial autotransporters are folded in a process that entraps segments of their N-terminal passenger domain. Here, Leyton et al. identify glycine-aromatic mortise and tenon motifs that mediate the passenger domain’s translocation to the bacterial cell surface, and show that the motifs are evolutionarily conserved.

    • Denisse L. Leyton
    • Matthew D. Johnson
    • Trevor Lithgow
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • Experimental stream manipulation in a mountain river system in the tropical Andes initiates a regime shift of benthic cyanobacteria. This whole-ecosystem experiment in conjunction with a global synthesis reveal regime shift tipping points dependent upon freshwater streamflow.

    • Daniela Rosero-López
    • M. Todd Walter
    • Olivier Dangles
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-8

    • F. S. M.
    Books & Arts
    Nature
    Volume: 137, P: 448-449

  • Three broad recommendations have been made for the management of children with intersex conditions: halt all infant cosmetic genital surgery until evidence-based guidelines are available; conduct further research on the necessity of such surgery; and practice complete honesty with parents and patients. The authors discuss whether clinical practice has changed in response to these recommendations.

    • Milton Diamond
    • Hazel G Beh
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 4, P: 4-5

  • Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on elucidating the role of the tumour microenvironment and the microbiome in the development and progression of the disease, as well as on the promising potential of artificial intelligence for early diagnosis and outcome prediction.

    • Minoti Apte
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 22, P: 96-97

    • A. M. SMITH
    Books & Arts
    Nature
    Volume: 208, P: 718-719

  • Adipocyte progenitors have the capacity to differentiate into mature brown adipocytes with thermogenic capabilities. Two new studies identify novel markers to help prospectively isolate these and mature adipocytes from human brown fat biopsies.

    • Mariëtte R Boon
    • Emmani B M Nascimento
    • Wouter D van Marken Lichtenbelt
    News & Views
    Nature Medicine
    Volume: 21, P: 667-668

  • This article aims to make the methodology behind the recent spate of papers reportingin situimmune-cell imaging more accessible to the reader and to highlight potential artefacts so that the reader can analyse the data more critically.

    • Ronald N. Germain
    • Mark J. Miller
    • Michel C. Nussenzweig
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 497-507

    • M. R. HOARE
    Books & Arts
    Nature
    Volume: 249, P: 193-194

    • F. I. M. CRAIK
    Books & Arts
    Nature
    Volume: 216, P: 1051-1052

    • JOAN M. EYLES
    Books & Arts
    Nature
    Volume: 177, P: 1144-1145

    • P.M. Kelly
    Books & Arts
    Nature
    Volume: 315, P: 161

  • The ability to generate personalized genomic information for large numbers of people is rapidly becoming a reality. Four experts provide their opinions on how useful this information is likely to be and how it should best be put to use.

    • Alan E. Guttmacher
    • Amy L. McGuire
    • Kári Stefánsson
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 161-165

    • M. G. KENDALL
    Books & Arts
    Nature
    Volume: 173, P: 1159

  • The Galapagos Islands inspired the theory of evolution by means of natural selection; now in the Anthropocene, the Galapagos represent an important natural laboratory to understand ecosystem resilience in the face of climate extremes and enable effective socio-ecological co-evolution under climate change.

    • P. Salinas-de-León
    • S. Andrade
    • B. Worm
    Comments & Opinion
    Nature Climate Change
    Volume: 10, P: 380-382

    • M. J. CHADWICK
    Books & Arts
    Nature
    Volume: 235, P: 232

    • H. M. CHARLTON
    Books & Arts
    Nature
    Volume: 249, P: 867

    • L. M. MILNE-THOMSON
    Books & Arts
    Nature
    Volume: 141, P: 454-455