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Antipodes of large basins on the moon exhibit large areas of crustal magnetism. Here, the authors show that antipodal ejecta contains sufficient impactor material to explain the observed magnetization.

The authors show that the Martian crust, ~4300 km from the InSight landing site, has a subsurface interface similar to that beneath the lander, suggesting it is a regional or global feature that may be related to the closure of pore spaces at depth.

Several general ‘rules’ have emerged over the years about the requirements for transcription of genes. One of these was that the TATA-binding protein (TBP) is essential, both for initiation of transcription by recognizing the promoter, and for assembly of transcription complexes. A new study looks set to overturn this dogma by identifying a complex that does not contain TBP (the so-called TBP-free TAFII-containing complex, TFTC) yet can still support transcription.

Non-basaltic volcanism is rare on the Moon and has been found predominantly on the lunar nearside. Analysis of Lunar Reconnaissance Orbiter Camera images and spectral data reveal the presence of compositionally evolved, non-basaltic volcanism on the lunar farside.

Endogenous formation of nitroxyl has been discovered by real-time detection in plant cells. Evidence shows that nitroxyl has a specific accumulation pattern different from nitric oxide in response to senescence- and hypoxia-induced redox shifts.

Alkali metal-based coordination polymers are promising precursors for the synthesis of porous materials. Here, (Li, Na, K)-based coordination polymers with 1,3,5-benzenetricarboxylate as an organic linker are used for the synthesis of porous carbon materials with large surface area for use in supercapacitors.

Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

Lunar impact basins formed during the magma ocean solidification should have formed almost unidentifiable topographic and crustal thickness signatures, thus may escape detection. This result allows for a higher impact flux in the earliest epoch of Earth-Moon evolution.

Rapid eye movement (REM) sleep is a sleep phase characterised by random eye movements for which the underlying motor commands are yet to be revealed. The authors describe that a cluster of medulla oblongata neurons in the Nucleus papiliocontributes to the control of eye movements during REM sleep.

Emplacement of the north polar cap of Mars is investigated by combining viscoelastic deformation calculations and observations, showing that it formed over the last 1.7–12.0 Myr atop a stiff lithosphere and high-viscosity mantle (10²² Pa s), and that glacial isostatic adjustment could be further constrained.

Gravity data show a rectangular pattern of narrow linear anomalies bordering the lunar Procellarum region that are interpreted to be the frozen remnants of lava-filled rifts and underlying feeder dykes.

Mutations in genes encoding subunits of the BAF complex can cause Coffin–Siris and Nicolaides–Baraitser syndromes. Here the authors identify overlapping DNA methylation signatures in individuals with subtypes of these two syndromes that suggest a functional link and can be used to diagnose subjects with unclear clinical presentations.

Aircraft measurements over the Amazon show that new particle formation in the upper troposphere emerges when isoprene, emitted by forests, undergoes oxidation in the presence of nitrogen oxides produced by lightning.

Experiments performed in the CERN CLOUD chamber show that, under upper-tropospheric conditions, new atmospheric particle formation may be initiated by the reaction of hydroxyl radicals with isoprene emitted by rainforests.

An adjuvanted SARS-CoV-2 spike-ferritin nanoparticle vaccine can elicit antibodies with relatively broad sarbecovirus activity in non-human primates. Here, the authors isolate and structurally characterize several monoclonal antibodies providing insights into the targeted epitopes and broad reactivity.

Krebs and colleagues identify multiple mAbs that recognize either the RBD or the NTD of SARS-CoV-2 spike protein that have potent cross-neutralizing activities against variants of concern. Combinatorial mAb cocktails have complementary effects on viral neutralization and Fc effector functions and can protect against SARS-CoV-2 escape mutants.

Analysis of radio science data from the NASA InSight Mars lander reveals details of the rotation of the planet, which have been used to determine fundamental information about its core, mantle and atmosphere.

Manju Kurian and colleagues report heterozygous variants in KMT2B in 27 unrelated individuals with a complex progressive childhood-onset dystonia, often associated with a typical facial appearance. Their findings highlight a clinically recognizable form of dystonia and demonstrate a crucial role for KMT2B in the physiological control of voluntary movement.

In this pragmatic, randomized clinical trial involving 1,196 pregnant and postpartum women from 6 hospitals in Nigeria, AI-based electrocardiogram screening proved accurate in detecting cardiomyopathies and suggests that it could improve detection of these conditions.

Iodic acid (HIO₃) forms aerosols very efficiently, but its gas-phase formation mechanism is not well understood. Atmospheric simulation chamber experiments, quantum chemical calculations and kinetic modelling have now revealed that HIO₃ forms as an early iodine oxidation product from hypoiodite. The mechanism explains field measurements and suggests a catalytic role for iodine in particle formation.

The crust beneath the InSight lander on Mars is altered or fractured to 8–11 km depth and may bear volatiles, according to an analysis of seismic noise and wave scattering recorded by InSight’s seismometer.

SARS-CoV-2 variants of concern continue to emerge, reducing vaccine efficacy and limiting therapeutic options. Here, Chen and colleagues describe the identification and design of shark nanobodies with pansarbecovirus activity.

Johannes Dauwerse and colleagues report the identification of mutations in the genes encoding subunits of RNA polymerases I and III, which are involved in transcription of rRNA and tRNA, in individuals with Treacher Collins syndrome. These findings support the hypothesis that TCS is a ribosomopathy.

Han Brunner and colleagues report the identification of de novo nonsense mutations in ASXL1 in individuals with Bohring-Opitz syndrome, which is characterized by intellectual disability, distinctive facial features and multiple congenital malformations.

By performing experiments under upper tropospheric conditions, nitric acid, sulfuric acid and ammonia can form particles synergistically, at rates orders of magnitude faster than any two of the three components.

HIV-1 Env consensus sequences that reflect recent sequences for clades B, C, and CRF01_AE were redesigned using AI-assisted methods to shorten hypervariable loops and limit strain-specific targeting. The modified Envs show improved antibody binding.

A central antiviral defence is immune recognition of cystolic DNA. Here the authors show that RPA and RAD51, in cooperation with TREX1, function to protect the cytosol from self-DNA.

The planet Mercury rotates three times about its spin axis for every two orbits around the Sun. Numerical modelling suggests that this unusual pattern could result from initial retrograde rotation that was captured into a stable synchronous orbit, and subsequent disturbance by a large impact.

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Mars is seismically active: 24 subcrustal magnitude 3–4 marsquakes and 150 smaller events have been identified up to 30 September 2019, by an analysis of seismometer data from the InSight lander.

Measurements in the CLOUD chamber at CERN show that the rapid condensation of ammonia and nitric acid vapours could be important for the formation and survival of new particles in wintertime urban conditions, contributing to urban smog.

The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solutions to RNA recognition.