HIV’s persistence in diverse tissue reservoirs poses a challenge to cure efforts, necessitating targeted approaches. Here, the authors develop human tissue models of HIV latency and find that inducible reservoirs differ across tissues and CD4⁺ T-cell subsets, highlighting tissue-specific markers and IL-15 as the most effective latency reversal agent.
- A. Gallego-Cortés
- N. Sánchez-Gaona
- MJ. Buzon
