The authors show that normal apoAI/HDL and an apoAI mimetic have protective effects on damaged podocytes in culture. In vivo, infusion of the apoAI mimetic lessens glomerular damage, proteinuria, and atherosclerosis. These findings suggest that supplemental apoAI/apoAI mimetic 4F may be novel interventions to lessen podocyte damage, and the resulting proteinuria and atherosclerosis.
- Yohei Tsuchida
- Jianyong Zhong
- Valentina Kon
