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Showing 1–2 of 2 results
Advanced filters: Author: Madeleine Dias Mirandela Clear advanced filters

  • In mice, a SPOCD1–TPR-dependent ‘nowhere-to-hide’ mechanism is required for complete non-stochastic piRNA-directed LINE1 DNA methylation by preventing transposons from escaping surveillance within heterochromatin.

    • Tamoghna Chowdhury
    • Shelagh Boyle
    • Dónal O’Carroll
    Research
    Nature
    Volume: 650, P: 779-785

  • In male mouse germline development, the precise DNA methylation of young, active transposons requires a two-step process in which SPIN1 and SPOCD1 mark young LINE1 elements before the piRNA pathway triggers DNA methylation.

    • Madeleine Dias Mirandela
    • Ansgar Zoch
    • Dónal O’Carroll
    ResearchOpen Access
    Nature
    Volume: 634, P: 979-985