Nature Search

Trick and treat: Toward peptide mimic vaccines

Alexander R. Shikhman
Madeleine W. Cunningham
Research01 Jun 1997
Nature Biotechnology

Volume: 15, P: 512-513
Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism

Kathleen Connery
Marie Tippett
Richard E. Frye
ResearchOpen Access10 Aug 2018
Translational Psychiatry

Volume: 8, P: 1-14
Rheumatic fever revisited

Madeleine W. Cunningham
Correspondence14 Jan 2014
Nature Reviews Cardiology

Volume: 11, P: 123
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts

The parasitic helminth H. polygyrus secretes modular TGF-β mimic proteins to dampen host immunity. Here, the authors show H. polygyrus secretes a related protein which inhibits TGF-β signaling in fibroblasts to minimize fibrotic damage to the host.

Stephen E. White
Tristin A. Schwartze
Andrew P. Hinck
ResearchOpen Access21 Feb 2025
Nature Communications

Volume: 16, P: 1-15
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity

The role of IFN signaling in SARS-CoV-2 infection and outcome is still debated. Here, the authors longitudinally profiled plasma samples from hospitalized patients and show that a persistent inflammatory response is linked to delayed generation of adaptive immunity and increased risk of death when coupled with severe infection.

Elsa Brunet-Ratnasingham
Sacha Morin
Daniel E. Kaufmann
ResearchOpen Access16 May 2024
Nature Communications

Volume: 15, P: 1-19
Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea

Christine A Kirvan
Susan E Swedo
Madeleine W Cunningham
Research22 Jun 2003
Nature Medicine

Volume: 9, P: 914-920
Engineered human heart tissue reveals pathogenicity of autoantibodies in systemic lupus erythematosus

IgG autoantibodies from patients with systemic lupus erythematosus (SLE) and systolic dysfunction directly affect engineered human heart tissue, altering cellular composition, respiration and calcium handling. Four pathogenic autoantibodies that may target cardiomyocyte function provide insights into myocardial injury in SLE.

Madeleine W. Cunningham
News & Views29 Aug 2024
Nature Cardiovascular Research

Volume: 3, P: 1028-1030
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Cerebellar deep brain stimulation for chronic post-stroke motor rehabilitation: a phase I trial

A phase I trial of cerebellar deep brain stimulation to enhance chronic post-stroke motor rehabilitation supports the safety and feasibility of the approach while providing encouraging evidence of motor improvements.

Kenneth B. Baker
Ela B. Plow
André G. Machado
ResearchOpen Access14 Aug 2023
Nature Medicine

Volume: 29, P: 2366-2374
Streptococci target inflammasome

The Streptococcus pyogenes surface M protein is a critical multifunctional virulence factor. Recent work sheds light on a new unexpected function of the M protein in activating the host inflammasome to induce macrophage cell death and promote infection.

Madeleine W. Cunningham
News & Views26 Sept 2017
Nature Microbiology

Volume: 2, P: 1334-1335
Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

Kevin W. Ng
Jesse Boumelha
George Kassiotis
Amendments and CorrectionsOpen Access14 Jan 2026
Nature

Volume: 649, P: 1330
No compelling evidence that vaccination with streptococcus pyogenes group A carbohydrate elicits cross-reactive rheumatic fever autoantibodies

Tom Parks
Madeleine W. Cunningham
Allan Saul
ReviewsOpen Access03 Nov 2025
npj Vaccines

Volume: 10, P: 1-11
Determinants of volatile organic compound exposure among children with bronchopulmonary dysplasia

Bob Z. Sun
Morgan E. Ryan
Jonathan M. Gaffin
ResearchOpen Access23 Dec 2025
Pediatric Research

P: 1-6
RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

In lung adenocarcinoma, antibodies against endogenous retroviruses promote anti-tumour activity, and expression of endogenous retroviruses can predict outcomes of immunotherapy.

Kevin W. Ng
Jesse Boumelha
George Kassiotis
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 563-573
Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders

Lior Brimberg
Itai Benhar
Daphna Joel
Research25 Apr 2012
Neuropsychopharmacology

Volume: 37, P: 2076-2087
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Acute rheumatic fever and rheumatic heart disease

Acute rheumatic fever (ARF) is caused by an autoimmune response to group A streptococcal infection. Severe and/or repeated episodes of ARF can lead to rheumatic heart disease (RHD). Both conditions predominantly affect those experiencing economic disadvantage.

Jonathan R. Carapetis
Andrea Beaton
Liesl Zühlke
Reviews14 Jan 2016
Nature Reviews Disease Primers

Volume: 2, P: 1-24

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