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  • A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic reprogramming.

    • Chien-Wen Chen
    • David Papadopoli
    • Maria Hatzoglou
    ResearchOpen Access
    Nature
    Volume: 641, P: 1319-1328