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Showing 1–7 of 7 results
Advanced filters: Author: Maksim Mamonkin Clear advanced filters

  • Immunotherapies that employ engineered T cells rely on the selective and high expression of the targeted antigen in cancer cells and thus tumor heterogeneity compromises therapeutic success. Here authors generate an engineered T cell coreceptor that targets a secondary antigen and selectively enhances antigen receptor sensitivity in T cells.

    • Chiou-Tsun Tsai
    • Jorge Ibanez-Vega
    • Maksim Mamonkin
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-16

  • A study in mouse models of allogeneic stem cell transplantation with donor-derived CD19 chimeric antigen receptor (CAR) T cells for the treatment of relapsed B cell malignancies indicates that T cell exhaustion might have a role in preventing allogeneic reactivity of CD19 CAR T cells.

    • Maksim Mamonkin
    • Helen E Heslop
    News & Views
    Nature Medicine
    Volume: 23, P: 147-148

  • In a phase 1 trial followed by translational analyses, patients with acute myeloid leukemia (AML) treated with chimeric antigen receptor (CAR) T cell therapy targeting CD123 experienced high levels of cytokine release syndrome and short-lived clinical responses, probably due to CAR T cell-derived cytokines increasing the viability of AML blasts and antigen persistence.

    • Anand S. Bhagwat
    • Leonel Torres
    • Saar I. Gill
    Research
    Nature Medicine
    Volume: 30, P: 3697-3708

  • Therapeutic T cells bearing ligands engineered to optimize adhesion and transmigration through the blood–brain barrier can be targeted to brain tumours.

    • Heba Samaha
    • Antonella Pignata
    • Nabil Ahmed
    Research
    Nature
    Volume: 561, P: 331-337