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Nature Immunology (2)

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Immunology

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Advanced filters: Author: Malena Rohde Clear advanced filters

Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332_gp120 glycan-independent epitope

An anti-HIV-1 antibody that targets an N332_gp120 glycan-independent V3 epitope, a site of Env vulnerability, can decline viremia in HIV-1-infected humanized mice while overcoming classical V3 escape mutations.

Lutz Gieselmann
Andrew T. DeLaitsch
Florian Klein
ResearchOpen Access03 Feb 2026
Nature Immunology

P: 1-14
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy

Klein and colleagues characterize 04_A06, a new V_H1-2-encoded broadly neutralizing antibody that has marked breadth and potency against extended multiclade HIV-1 pseudovirus panels and can maintain full viral suppression in HIV-1-infected humanized mice.

Lutz Gieselmann
Andrew T. DeLaitsch
Florian Klein
ResearchOpen Access06 Oct 2025
Nature Immunology

Volume: 26, P: 2016-2029

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Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope

Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy

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Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332_gp120 glycan-independent epitope