Nature Search

The impact of social determinants of health on acute kidney injury

Social determinants of health can have a considerable impact on patient outcomes. Here, the authors examine how social determinants of health contribute to the growing global burden of acute kidney injury and its inequities, and discuss key strategies for tackling disparities in acute kidney injury care and outcomes.

Samira Bell
Rolando Claure-Del Granado
Shina Menon
Reviews04 Mar 2026
Nature Reviews Nephrology

P: 1-15
Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Local anesthetic sustained release systems suffer from untriggered rapid drug release upon application. Here the authors overcome this issue by covalently linking tetracaine to a polymer gel via a photo-cleavable linkage, enabling light-triggered and repeatable drug release.

Wei Zhang
Tianjiao Ji
Daniel S. Kohane
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-8
Exploring novel resistant sources for chilli leaf curl disease in Capsicum annuum L. germplasm for genetic enhancement

D. D. Deepika
Vedprakash Sharma
Vinod K. Sharma
ResearchOpen Access01 Feb 2026
Scientific Reports

Volume: 16, P: 1-12
Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel

A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.

Tianjiao Ji
Yang Li
Daniel S. Kohane
Research13 Sept 2021
Nature Biomedical Engineering

Volume: 5, P: 1099-1109
Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles

Current treatments of wet age-related macular degeneration require repeated injections of active drugs into the vitreous. Here Wang et al. develop nanoparticles that when injected intravenously can be targeted to the eye by irradiation with blue light, allowing local and enhanced drug release in the back of the eye, and providing an alternative to current delivery strategies.

Yanfei Wang
Chi-Hsiu Liu
Daniel S. Kohane
ResearchOpen Access18 Feb 2019
Nature Communications

Volume: 10, P: 1-9
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaesthetic.

Chao Zhao
Andong Liu
Daniel S. Kohane
ResearchOpen Access12 Jun 2019
Nature Communications

Volume: 10, P: 1-14
Mapping disparities in education across low- and middle-income countries

Analyses of the proportions of individuals who have completed key levels of schooling across all low- and middle-income countries from 2000 to 2017 reveal inequalities across countries as well as within populations.

Nicholas Graetz
Lauren Woyczynski
Simon I. Hay
ResearchOpen Access25 Dec 2019
Nature

Volume: 577, P: 235-238
Pregnancy-associated acute kidney injury — consensus report of the 32nd Acute Disease Quality Initiative workgroup

Pregnancy-associated acute kidney injury is a risk factor for maternal and fetal morbidity and mortality and a driver of health inequity worldwide. This Consensus Statement from the Acute Disease Quality Initiative provides recommendations on the causes, diagnosis, management and follow-up of pregnancy-associated acute kidney injury.

Cathy Nelson-Piercy
Nattachai Srisawat
Marlies Ostermann
Reviews18 Jul 2025
Nature Reviews Nephrology

Volume: 21, P: 633-646
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

Ten years after the discovery of the Higgs boson, the ATLAS experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 52-59
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Unbiased self supervised learning of kidney histology reveals phenotypic and prognostic insights

Krutika Pandit
Nicolas Coudray
Jeffrey Schelling
ResearchOpen Access08 Oct 2025
Scientific Reports

Volume: 15, P: 1-12
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention.

Stephanie A. Kujawski
Karen K. Wong
Jing Zhang
Research23 Apr 2020
Nature Medicine

Volume: 26, P: 861-868
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Genetic abnormalities in a large cohort of Coffin–Siris syndrome patients

Futoshi Sekiguchi
Yoshinori Tsurusaki
Naomichi Matsumoto
Research17 Sept 2019
Journal of Human Genetics

Volume: 64, P: 1173-1186
Early manifestations of type 1 Gaucher disease in presymptomatic children diagnosed after parental carrier screening

Amy C. Yang
Louise Bier
Manisha Balwani
Research13 Oct 2016
Genetics in Medicine

Volume: 19, P: 652-658
Author Correction: A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

G. Aad
B. Abbott
L. Zwalinski
Amendments and CorrectionsOpen Access18 Oct 2023
Nature

Volume: 623, P: E5
The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 1—global current practice patterns for the management of Herpes Simplex Virus and Varicella Zoster Virus anterior uveitis

Zheng Xian Thng
Ikhwanuliman Putera
Yun Feng
Research07 Jul 2023
Eye

Volume: 38, P: 61-67
The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 2—global current practice patterns for the management of Cytomegalovirus anterior uveitis

Zheng Xian Thng
Ikhwanuliman Putera
Yun Feng
Research07 Jul 2023
Eye

Volume: 38, P: 68-75

Search

The impact of social determinants of health on acute kidney injury

Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Exploring novel resistant sources for chilli leaf curl disease in Capsicum annuum L. germplasm for genetic enhancement

Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel

Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

Mapping disparities in education across low- and middle-income countries

Pregnancy-associated acute kidney injury — consensus report of the 32nd Acute Disease Quality Initiative workgroup

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

The Somatic Mosaicism across Human Tissues Network

Unbiased self supervised learning of kidney histology reveals phenotypic and prognostic insights

Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Genetic abnormalities in a large cohort of Coffin–Siris syndrome patients

Early manifestations of type 1 Gaucher disease in presymptomatic children diagnosed after parental carrier screening

Author Correction: A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 1—global current practice patterns for the management of Herpes Simplex Virus and Varicella Zoster Virus anterior uveitis

The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 2—global current practice patterns for the management of Cytomegalovirus anterior uveitis

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