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Showing 1–3 of 3 results
Advanced filters: Author: Manlio Fusciello Clear advanced filters

  • Beta-glucan is an inducer of trained immunity, an epigenetic and metabolic reprogramming of the innate immune cells conferring immunological memory. Here the authors show that glucan-induced trained immunity enhances response to a cancer vaccine platform in colorectal cancer models, by inducing epigenetic and metabolic rewiring of macrophages that promotes an NK-cDC1 axis boosting anti-tumor immunity.

    • Firas Hamdan
    • Sara Gandolfi
    • Vincenzo Cerullo
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-20

  • Cancer therapy using oncolytic virus has shown pre-clinical and clinical efficacy. Here, the authors report ExtraCRAd, an oncolytic virus cloaked with tumour cell membrane and report its therapeutic effects in vitro and in vivo in multiple mouse tumour models.

    • Manlio Fusciello
    • Flavia Fontana
    • Vincenzo Cerullo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Malignant pleural mesothelioma is an aggressive cancer with a poor prognosis and limited therapeutic options. Here the authors report the immunopeptidomic landscape of murine and human mesothelioma tumors and demonstrate the anti-tumor potential of oncolytic adenoviruses coated with so-defined tumor-specific peptides in a mouse model of mesothelioma.

    • Jacopo Chiaro
    • Gabriella Antignani
    • Vincenzo Cerullo
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16