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Haplotype-resolved, gap-free genome assemblies provide insights into the divergence between Asian and European pears

Haplotype-resolved, gap-free genome assemblies for a representative Asian pear (Pyrus bretschneideri, ‘Dangshansuli’) and a European pear (Pyrus communis, ‘Max Red Bartlett’) provide insights into genome evolution and interspecies variation in Pyrus species.

Manyi Sun
Beibei Cao
Jun Wu
ResearchOpen Access06 Aug 2025
Nature Genetics

Volume: 57, P: 2040-2051
Ulinastatin in the treatment of radiotherapy-induced oral mucositis in locoregionally advanced nasopharyngeal carcinoma: a phase 3 randomized clinical trial

Radiotherapy-induced oral mucositis is a common side effect in nasopharyngeal carcinoma treatment. Here, the authors present a phase 3 randomized clinical trial assessing the safety and efficacy of ulinastatin to prevent the incidence and severity of this condition.

Xuguang Wang
Haijun Wu
Lin Wang
ResearchOpen Access23 Mar 2025
Nature Communications

Volume: 16, P: 1-9
Exercise increases bone mass by lactate/Gpr81 signaling pathway

Exercise boosts bone mass, with HIIT more effective than LICT. HIIT-derived lactate activates Gpr81: it promotes osteoblast differentiation via Gpr81-Wnt/β-catenin and inhibits osteoclast via Gpr81-TAK1-p65, rescuing OVX-induced bone loss, offering Gpr81 as a potential osteoporosis target.

Yilan Guo
Liang He
Peng Sun
ResearchOpen Access10 Nov 2025
Communications Biology

Volume: 8, P: 1-16
Genome-wide association studies provide insights into the genetic determination of fruit traits of pear

Studies of fruit quality traits in pears are lagging behind the other major fruit trees. Here, the authors conduct GWAS of fruit quality and phenological traits in a panel of 312 sand pear accessions using SNPs called from resequencing data, and reveal the involvement of a lignin formation-related protein in regulating stone cell development.

Ming-Yue Zhang
Cheng Xue
Jun Wu
ResearchOpen Access18 Feb 2021
Nature Communications

Volume: 12, P: 1-10
A core driver gene set identified based on geMER reveals its potential driver mechanism in pan-cancer

Jing Gan
Yuncong Wang
Hui Zhi
ResearchOpen Access09 Aug 2025
npj Precision Oncology

Volume: 9, P: 1-19
The sweet burden: Does homeownership improve the economic status of households?

Manyi Luo
Shihu Zhong
Jie Chen
ResearchOpen Access05 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-10
Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates

Manyi Yang
Shaochun Yuan
Anlong Xu
Research20 Sept 2011
Cell Research

Volume: 21, P: 1410-1423

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Haplotype-resolved, gap-free genome assemblies provide insights into the divergence between Asian and European pears

Ulinastatin in the treatment of radiotherapy-induced oral mucositis in locoregionally advanced nasopharyngeal carcinoma: a phase 3 randomized clinical trial

Exercise increases bone mass by lactate/Gpr81 signaling pathway

Genome-wide association studies provide insights into the genetic determination of fruit traits of pear

A core driver gene set identified based on geMER reveals its potential driver mechanism in pan-cancer

The sweet burden: Does homeownership improve the economic status of households?

Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates

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