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Showing 1–3 of 3 results
Advanced filters: Author: Maofei Chen Clear advanced filters

  • The 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme complex regulating the TCA cycle. Here, the authors use cryo-EM and cryo-ET to discern native structures of the whole complex and reveal its assembly mechanism.

    • Yitang Zhang
    • Maofei Chen
    • Maojun Yang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Piezo1, a mechanosensitive cation channel, senses shear stress of blood flow for proper blood vessel development, regulates red blood cell function and controls cell migration and differentiation; here a trimeric architecture of this novel class of ion channel is reported, suggesting that Piezo1 may use its peripheral propeller-like ‘blades’ as force sensors to gate the central ion-conducting pore.

    • Jingpeng Ge
    • Wanqiu Li
    • Maojun Yang
    Research
    Nature
    Volume: 527, P: 64-69