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Showing 1–3 of 3 results
Advanced filters: Author: Marc Altorfer Clear advanced filters

  • In this work, fragments identified by 19F-NMR are optimized into submicromolar binders of the MITF transcription factor. These results support direct targeting of bHLH-LZ DNA binding domains and provide a foundation for the development of new melanoma therapies.

    • Deborah Castelletti
    • Jürgen Hinrichs
    • Wolfgang Jahnke
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • YAP activation is a key driver in both malignant pleural mesothelioma and uveal melanoma through engagement of different regulatory elements. Here, the authors use functional epigenomic analyses to reveal lineage-specific YAP-dependent cistrome.

    • Inês A. M. Barbosa
    • Rajaraman Gopalakrishnan
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Using deep mutational scanning, the authors uncover the functional consequence of missense mutations in ARID1B, a subunit of the SWI/SNF chromatin remodeling complex that is frequently mutated in human Coffin–Siris syndrome and in cancer.

    • Fanny Mermet-Meillon
    • Samuele Mercan
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1018-1022