Search

Measurements on a chiral magnet show that non-symmorphic symmetries enforce topological crossings exactly at the Fermi level in certain materials; these crossings can be controlled by an applied magnetic field.

Analyses of snRNA genes in a French cohort of people with rare disorders, with validation through international collaboration, identify monoallelic and biallelic variants in RNU2-2 as frequent causes of neurodevelopmental disorders with epilepsy.

During morphogenesis patterned contractility drives tissue shape changes. Here they show that GPCR signaling and integrin activation give rise to a dynamically translocating gradient of contractility required for a self-organized wave of tissue invagination.

Planar growth of nanowire arrays involves interactions between materials that affect the electronic behavior of the effective heterojunction. Here, authors show how core curvature and cross-section morphology affect shell growth, demonstrating how strain at the core-shell interface induces electronic band modulations in ZnSe@ZnTe nanowires.

Quantum oscillations in the three-dimensional topological semimetal CoSi are reported, where selected oscillation frequencies have no corresponding extremal Fermi surface cross-sections, representing instead oscillations of the quasiparticle lifetime.

The recent discovery of charge order in YBa₂Cu₃O_y was unexpected. A systematic study of the evolution of this phenomenon as a function of magnetic field conducted by Wu et al. reveals how the competition between charge order and superconductivity may actually be universal to the underdoped cuprates.

Understanding the electric double layer of liquid–electrode interfaces is essential for understanding electrochemical processes. Now it has been shown that structure-dependent water dissociation and hydroxyl adsorption at step sites dictate the double-layer capacitance and potential of zero charge, directly linking model single crystals with practical platinum electrodes.

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

Lasing with multi-pass gain is achieved in a diamond-based X-ray cavity at the European XFEL, opening a path to next-generation X-ray science.

Electrocatalytic CO₂ reduction is typically studied at laboratory scale under ambient conditions; however, temperature and pressure may have a profound impact on the mechanism of this reaction and on its relevance to industrial applications. This study uses a custom temperature- and pressure-adjustable cell to reveal a chain growth mechanism emerging on copper electrodes at elevated temperatures and pressures.

Tissues eliminate unwanted cells through cell extrusion, but the factors determining whether these extuded cells live or die are not fully understood. Now force transmission across adherens junctions is shown to have a role in shaping their fate.

Gastrointestinal motility disorders affect over 20% of the population, yet current therapies provide limited relief. Here, the authors show that in a swine model a closed-loop GI neuroprosthesis restores peristalsis and enhances metabolic responses via targeted electrical and chemical stimulation

The Einstein-de Haas effect is a manifestation of the conservation of angular momentum, causing a magnetic object to rotate as its magnetization state is changed. Here, the authors demonstrate this effect at the single spin level for a molecular magnet suspended on a nanomechanical resonator.

Nonlinear structured illumination microscopy is a super-resolution technique that is challenging to extend to 3 dimensions. The authors obtain super-resolution image information in 3D from a 2D scan by exploiting orthogonal speckle illumination patterns and compressed sensing of the sparse fluorescence.

Understanding cuprate superconductors requires better knowledge of the microscopic structure of their charge-density waves (CDW). Here, the authors report evidence that the long-range CDW order in YBa₂Cu₃O_y has a local commensurate period of three unit cells.

Fluorescent calcium imaging reveals the firing patterns of brain cells, but microscopy in behaving animals is challenging due to brain motion. Here, the authors develop a two-photon fluorescent microscope to record from many cells in a brain volume of freely-behaving Drosophila larvae.

Aqueous zinc batteries suffer from hydrogen evolution and dendrite growth during zinc plating. Here, authors report zinc oligoether salts as electrolyte additives to promote the formation of passivation layer on Zn metallic electrode and extend the lifetime of aqueous Zn-based batteries.

This study reports that de novo germline missense variants in SF3B1, distinct from the somatic variants frequently observed in cancer, cause a neurodevelopmental disorder and disrupt global RNA splicing.

Dehapiot et al. show two actin networks at the cell surface in Drosophila embryos. While the pulsatile network controls local deformation, the Frl-dependent persistent network promotes force propagation.

With free-space optical communications in mind, researchers used a nanostructured birefringent metasurface to achieve a 16-fold increase in the corrected beam signal in mid-to-high-turbulence conditions. Benefits of the noise-tolerant approach to wavefront reconstruction with high resolution are demonstrated.

PetaKit5D offers versatile processing workflows for light sheet microscopy data including performant image input/output, geometric transformations, deconvolution and stitching. The software is efficient and scalable to petabyte-size datasets.

Ginhoux, Dutertre and colleagues provide a comprehensive analysis of dendritic cell subsets and states across human tumoral and juxtatumoral tissues.

A fluidic system with spatially reconfigurable hot spots generated by optical pumping of plasmonic nanorods is demonstrated, creating virtual barriers by generating local heating via photothermal conversion, for potential applications in chemical synthesis, lab-on-chip devices and microbiology.

Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

Cell extrusion regulates monolayer cell density and is critical in maintaining epithelia integrity, which has implications in homeostasis, development, and cancer progression. Here the authors describe how monolayer integrate mechanical signals from tissue mechanics, cell-cell adhesion, cell-substrate adhesion and cytoskeleton coordinate cell extrusion.

Working memory improves during adolescent brain development. Zhu et al. tracked monkeys through adolescence, revealing that maturation of white matter tracts and refinement of neural firing patterns sharpen working memory precision.

In high-temperature superconductors, a very low density of states, the pseudogap, exists even above the critical temperature. Here, the authors show that this is also the case for a conventional superconductor, titanium nitride thin films, and that this pseudogap is induced by superconducting fluctuations.

Epitaxial growth followed by topotactic reduction yields superconducting nickelate phases with the same hole-doping level as that obtained by chemical substitution, without causing structural disorder.

The use of terahertz pulses to 'gate' interlayer charge transport in a superconductor could lead to a variety of new and interesting applications.

Atomic point defects formed by irradiation can dramatically alter material properties, but are difficult to probe, limiting understanding of their impact. Here, the authors introduce an x-ray microscopy approach, based on Bragg ptychography, to visualise the distortion caused by these otherwise invisible defects.

Self-configuring meshes of integrated Mach–Zehnder interferometers determine the optimal communication channels through unknown optical media, with the resulting modes showing crosstalk below –30 dB.

The MICrONS mouse visual cortex dataset shows that neurons with similar response properties preferentially connect, a pattern that emerges within and across brain areas and layers, and independently emerges in artificial neural networks where these ‘like-to-like’ connections prove important for task performance.

The nature and universality of the ordering phenomena observed in the normal state of high-temperature superconductors remain unclear. Here, Wu et al. observe several aspects of incipient charge ordering in YBCO via NMR measurements, clarifying the role of quenched disorder in their emergence.

Tissue shape changes in the posterior endoderm of the early Drosophila embryo are driven by actomyosin contractions emerging from a transcriptional induction followed by a mechanically-driven propagation of RhoI–myosin II activation.

Bulk vanadium dioxide undergoes a metal–insulator transition near room temperature. It is now shown that by putting a thin layer of vanadium dioxide on a buffer, and varying the buffer’s thickness, the orbital occupancy in the metallic state and the transition temperature can be tuned.

Radiotherapy is a key component of glioblastoma therapy, however, difficulties in delivering high doses to tumours cells while preserving healthy tissues risks limits its success. Here, the authors report a phase I dose escalation study investigating convection enhanced delivery of Rhenium (186Re) Obisbemeda (186RNL), chelated-186Re encapsulated in nanoliposomes, in patients with recurrent, high-grade malignant glioma.

Resonant X-ray excitation of the  ⁴⁵Sc nuclear isomeric state was achieved by irradiation of a Sc-metal foil with 12.4-keV photon pulses from a state-of-the-art X-ray free-electron laser, allowing a high-precision determination of the transition energy.

A computer Go program based on deep neural networks defeats a human professional player to achieve one of the grand challenges of artificial intelligence.

A centimetre-long string formed by the hierarchical self-assembly of a photoresponsive amphiphilic molecular motor — composed of 95 wt% of water — undergoes muscle-like contraction. Under irradiation, rotary motion at the molecular level is amplified through non-covalent interactions to sustain a fast macroscopic mechanical motion of large amplitude.