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Showing 1–4 of 4 results
Advanced filters: Author: Marco Becilli Clear advanced filters

  • In the final analysis of a phase 1/phase 2 trial of autologous GD2-targeting CAR T cells in pediatric patients with high-risk metastatic, relapsed or refractory neuroblastoma, treatment was overall well tolerated, with an objective response rate of 66%. These findings were further supported by a case series involving the same therapy in a similar patient population.

    • Franco Locatelli
    • Daria Pagliara
    • Francesca del Bufalo
    Research
    Nature Medicine
    Volume: 31, P: 3689-3699

  • In this case series of patients with T cell acute lymphoblastic leukemia (T-ALL), therapy with CD7-directed CAR T cells that express an anti-CD7 protein expression blocker to prevent CAR T-induced fratricide showed encouraging rates of clinical response and persistence of circulating CAR T cells.

    • Bernice L. Z. Oh
    • Noriko Shimasaki
    • Dario Campana
    Research
    Nature Medicine
    Volume: 30, P: 3687-3696

  • In a case series of five children with treatment-refractory neuroblastoma, it was feasible to manufacture and administer donor-derived GD2-specific CAR T cells and clinical responses were seen in four patients.

    • Concetta Quintarelli
    • Francesca Del Bufalo
    • Franco Locatelli
    Research
    Nature Medicine
    Volume: 31, P: 849-860